Discovery of novel 5-(ethyl or hydroxymethyl) analogs of 2a2-aupa fluoro (or hydroxyl) pyrimidine nucleosides as a new class of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium avium inhibitors

Discovery of novel antimycobacterial compounds that work on distinctive targets and by diverse mechanisms of action is urgently required for the treatment of mycobacterial infections due to the emerging global health threat of tuberculosis. We have identified a new class of 5-ethyl or hydroxy (or me...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Bioorganic & medicinal chemistry 2012-07, Vol.20 (13), p.4088-4097
Hauptverfasser:	Shakya, Neeraj, Srivastav, Naveen C, Bhavanam, Sudha, Tse, Chris, Desroches, Nancy, Agrawal, Babita, Kunimoto, Dennis Y, Kumar, Rakesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemotherapy Cross-resistance Cycloserine Drugs Infection Isoniazid Mycobacterium avium Mycobacterium bovis Mycobacterium tuberculosis nucleosides pyrimidines Replication Toxicity Tuberculosis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!