6-Shogaol, a ginger product, modulates neuroinflammation: A new approach to neuroprotection

Inflammatory processes in the central nervous system play an important role in a number of neurodegenerative diseases mediated by microglial activation, which results in neuronal cell death. Microglia act in immune surveillance and host defense while resting. When activated, they can be deleterious...

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Veröffentlicht in:	Neuropharmacology 2012-08, Vol.63 (2), p.211-223
Hauptverfasser:	Ha, Sang Keun, Moon, Eunjung, Ju, Mi Sun, Kim, Dong Hyun, Ryu, Jong Hoon, Oh, Myung Sook, Kim, Sun Yeou
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Ischemia - drug therapy Brain Ischemia - metabolism Catechols - pharmacology Catechols - therapeutic use Cells, Cultured Coculture Techniques Cytokines - biosynthesis Dinoprostone - biosynthesis Down-Regulation - drug effects Encephalitis - drug therapy Encephalitis - metabolism Ginger Inflammation Mediators - pharmacology Ischemia Male Mice Microglia Microglia - drug effects Microglia - metabolism Neurons - drug effects Neurons - metabolism Neuroprotection Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Nitric Oxide - biosynthesis Nitric Oxide Synthase Type II - metabolism Plant Extracts - pharmacology Plant Extracts - therapeutic use Rats, Sprague-Dawley Shogaol Zingiber officinale
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