Importance of the dense fine speckled pattern on HEp-2 cells and anti-DFS70 antibodies for the diagnosis of systemic autoimmune diseases

Abstract The presence of anti-nuclear antibodies (ANA) is a hallmark of systemic autoimmune rheumatic diseases (SARD). The indirect immunofluorescence (IIF) assay on HEp-2 cells is a commonly used test for the detection of ANA and was recently recommended as the screening test of choice by a task fo...

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Veröffentlicht in:	Autoimmunity reviews 2012-07, Vol.11 (9), p.642-645
Hauptverfasser:	Mahler, Michael, Hanly, John G, Fritzler, Marvin J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - immunology Algorithms Allergy and Immunology ANA Antibodies Antibodies, Antinuclear - blood Antibodies, Antinuclear - immunology Autoimmune disease Autoimmune diseases Autoimmune Diseases - diagnosis Autoimmune Diseases - immunology DFS False Positive Reactions Fluorescent Antibody Technique, Indirect Hep G2 Cells Humans Immunofluorescence LEDGF Reviews Rheumatic diseases Sensitivity and Specificity Staining and Labeling Transcription Factors - genetics Transcription Factors - immunology
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