Does spatial cueing affect line bisection in chronic hemianopia?
► Hemianopia (HA) is associated with a horizontal line bisection error (HLBE). ► We tested whether spatial-attentional cueing modulates the HLBE. ► 20 chronic HA patients with HLBE, 3 neglect patients and 20 controls were tested. ► Spatial cueing had no effect on HLBE in HA, but in leftsided neglect...
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| description | ► Hemianopia (HA) is associated with a horizontal line bisection error (HLBE). ► We tested whether spatial-attentional cueing modulates the HLBE. ► 20 chronic HA patients with HLBE, 3 neglect patients and 20 controls were tested. ► Spatial cueing had no effect on HLBE in HA, but in leftsided neglect.
Patients with homonymous hemianopia often show a contralesional shift towards their blind field when bisecting horizontal lines (“hemianopic line bisection error”, HLBE). The reasons for this spatial bias are not well understood and debated. Cueing of spatial attention modulates line bisection significantly in patients with visuospatial neglect. Moreover, recent evidence showed that attention training significantly improves deficits of visual search in hemianopia. Here, we tested in 20 patients with chronic homonymous hemianopia (10 left-sided, 10 right-sided) without visual neglect, 10 healthy control subjects, 10 neurological control patients, and 3 patients with left visuospatial neglect and leftsided hemianopia whether spatial cueing influences the HLBE. Subjects indicated verbally the midpoint of horizontal lines in a computerized line bisection task under four experimental cue positions (cue far left, mid-left, mid-right or far-right within the horizontal line). All 20 hemianopic patients showed the typical HLBE towards their blind field, while the two control samples showed only a small but significant leftward shift (pseudoneglect). None of the 4 cueing manipulations had a significant effect on the HLBE in the hemianopic patients. Moreover, no differential effects of cueing on line bisection results were obtained when analyzed in lesion subgroups of hemianopic patients with circumscribed occipital lesions (N=8) as contrasted with patients having more extended (occipito-temporal or temporal) lesions (N=12). This null-effect contrasts with marked cueing effects observed in 3 neglect patients with left hemianopia in the same tasks, showing the principal efficacy of our cueing manipulation. These results argue against attentional explanations of the HLBE. |
| doi_str_mv | 10.1016/j.neuropsychologia.2012.03.021 |
| format | Article |
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Patients with homonymous hemianopia often show a contralesional shift towards their blind field when bisecting horizontal lines (“hemianopic line bisection error”, HLBE). The reasons for this spatial bias are not well understood and debated. Cueing of spatial attention modulates line bisection significantly in patients with visuospatial neglect. Moreover, recent evidence showed that attention training significantly improves deficits of visual search in hemianopia. Here, we tested in 20 patients with chronic homonymous hemianopia (10 left-sided, 10 right-sided) without visual neglect, 10 healthy control subjects, 10 neurological control patients, and 3 patients with left visuospatial neglect and leftsided hemianopia whether spatial cueing influences the HLBE. Subjects indicated verbally the midpoint of horizontal lines in a computerized line bisection task under four experimental cue positions (cue far left, mid-left, mid-right or far-right within the horizontal line). All 20 hemianopic patients showed the typical HLBE towards their blind field, while the two control samples showed only a small but significant leftward shift (pseudoneglect). None of the 4 cueing manipulations had a significant effect on the HLBE in the hemianopic patients. Moreover, no differential effects of cueing on line bisection results were obtained when analyzed in lesion subgroups of hemianopic patients with circumscribed occipital lesions (N=8) as contrasted with patients having more extended (occipito-temporal or temporal) lesions (N=12). This null-effect contrasts with marked cueing effects observed in 3 neglect patients with left hemianopia in the same tasks, showing the principal efficacy of our cueing manipulation. These results argue against attentional explanations of the HLBE.</description><identifier>ISSN: 0028-3932</identifier><identifier>EISSN: 1873-3514</identifier><identifier>DOI: 10.1016/j.neuropsychologia.2012.03.021</identifier><identifier>PMID: 22480681</identifier><identifier>CODEN: NUPSA6</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Action ; Adult ; Adult and adolescent clinical studies ; Aged ; Attention ; Biological and medical sciences ; Brain ; Chronic Disease ; Cues ; Diseases of visual field, optic nerve, optic chiasma and optic tracts ; Female ; Functional Laterality - physiology ; Hemianopia ; Hemianopsia - pathology ; Hemianopsia - physiopathology ; Humans ; Line bisection ; Male ; Medical sciences ; Middle Aged ; Neglect syndromes ; Neurologic Examination ; Neuropsychological Tests ; Ophthalmology ; Organic mental disorders. Neuropsychology ; Psychology. Psychoanalysis. Psychiatry ; Psychomotor Performance - physiology ; Psychopathology. Psychiatry ; Saccades ; Space ; Space Perception - physiology ; Vision ; Visual Fields - physiology ; Visual perception</subject><ispartof>Neuropsychologia, 2012-06, Vol.50 (7), p.1656-1662</ispartof><rights>2012 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-8a47227e00e44465f05fbcaf01bc16dc61a4b7a719c90939a34038c9a1ca8efd3</citedby><cites>FETCH-LOGICAL-c455t-8a47227e00e44465f05fbcaf01bc16dc61a4b7a719c90939a34038c9a1ca8efd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neuropsychologia.2012.03.021$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25954231$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22480681$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuhn, C.</creatorcontrib><creatorcontrib>Rosenthal, A.</creatorcontrib><creatorcontrib>Bublak, P.</creatorcontrib><creatorcontrib>Grotemeyer, K.H.</creatorcontrib><creatorcontrib>Reinhart, S.</creatorcontrib><creatorcontrib>Kerkhoff, G.</creatorcontrib><title>Does spatial cueing affect line bisection in chronic hemianopia?</title><title>Neuropsychologia</title><addtitle>Neuropsychologia</addtitle><description>► Hemianopia (HA) is associated with a horizontal line bisection error (HLBE). ► We tested whether spatial-attentional cueing modulates the HLBE. ► 20 chronic HA patients with HLBE, 3 neglect patients and 20 controls were tested. ► Spatial cueing had no effect on HLBE in HA, but in leftsided neglect.
Patients with homonymous hemianopia often show a contralesional shift towards their blind field when bisecting horizontal lines (“hemianopic line bisection error”, HLBE). The reasons for this spatial bias are not well understood and debated. Cueing of spatial attention modulates line bisection significantly in patients with visuospatial neglect. Moreover, recent evidence showed that attention training significantly improves deficits of visual search in hemianopia. Here, we tested in 20 patients with chronic homonymous hemianopia (10 left-sided, 10 right-sided) without visual neglect, 10 healthy control subjects, 10 neurological control patients, and 3 patients with left visuospatial neglect and leftsided hemianopia whether spatial cueing influences the HLBE. Subjects indicated verbally the midpoint of horizontal lines in a computerized line bisection task under four experimental cue positions (cue far left, mid-left, mid-right or far-right within the horizontal line). All 20 hemianopic patients showed the typical HLBE towards their blind field, while the two control samples showed only a small but significant leftward shift (pseudoneglect). None of the 4 cueing manipulations had a significant effect on the HLBE in the hemianopic patients. Moreover, no differential effects of cueing on line bisection results were obtained when analyzed in lesion subgroups of hemianopic patients with circumscribed occipital lesions (N=8) as contrasted with patients having more extended (occipito-temporal or temporal) lesions (N=12). This null-effect contrasts with marked cueing effects observed in 3 neglect patients with left hemianopia in the same tasks, showing the principal efficacy of our cueing manipulation. These results argue against attentional explanations of the HLBE.</description><subject>Action</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Attention</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Chronic Disease</subject><subject>Cues</subject><subject>Diseases of visual field, optic nerve, optic chiasma and optic tracts</subject><subject>Female</subject><subject>Functional Laterality - physiology</subject><subject>Hemianopia</subject><subject>Hemianopsia - pathology</subject><subject>Hemianopsia - physiopathology</subject><subject>Humans</subject><subject>Line bisection</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neglect syndromes</subject><subject>Neurologic Examination</subject><subject>Neuropsychological Tests</subject><subject>Ophthalmology</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychomotor Performance - physiology</subject><subject>Psychopathology. Psychiatry</subject><subject>Saccades</subject><subject>Space</subject><subject>Space Perception - physiology</subject><subject>Vision</subject><subject>Visual Fields - physiology</subject><subject>Visual perception</subject><issn>0028-3932</issn><issn>1873-3514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0ctu1DAUgGELgehQeAWUDYhNwvEtcTZQVC5FqsQG1taJc9zxKGMHe4LUtyejGUBi1ZW9-Hxs_WbsNYeGA2_f7ppIS05zuXfbNKW7gI0ALhqQDQj-iG246WQtNVeP2QZAmFr2UlywZ6XsAEBpYZ6yCyGUgdbwDbv6mKhUZcZDwKlyC4V4V6H35A7VFCJVQyjrPqRYhVi5bU4xuGpL-4AxzQHfP2dPPE6FXpzXS_bj86fv1zf17bcvX68_3NZOaX2oDapOiI4ASCnVag_aDw498MHxdnQtRzV02PHe9dDLHqUCaVyP3KEhP8pL9uY0d87p50LlYPehOJomjJSWYjlIZbjuTfsAyrVqe6GO9N2JupxKyeTtnMMe8_2Kjq61O_t_cHsMbkHaNfg64OX5rmXY0_j3-J_CK3h1BlgcTj5jdKH8c7rXSsijuzk5WiP-CpRtcYGiozHk9QPsmMJD3_QbEAyodQ</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Kuhn, C.</creator><creator>Rosenthal, A.</creator><creator>Bublak, P.</creator><creator>Grotemeyer, K.H.</creator><creator>Reinhart, S.</creator><creator>Kerkhoff, G.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20120601</creationdate><title>Does spatial cueing affect line bisection in chronic hemianopia?</title><author>Kuhn, C. ; Rosenthal, A. ; Bublak, P. ; Grotemeyer, K.H. ; Reinhart, S. ; Kerkhoff, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-8a47227e00e44465f05fbcaf01bc16dc61a4b7a719c90939a34038c9a1ca8efd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Action</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Attention</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Chronic Disease</topic><topic>Cues</topic><topic>Diseases of visual field, optic nerve, optic chiasma and optic tracts</topic><topic>Female</topic><topic>Functional Laterality - physiology</topic><topic>Hemianopia</topic><topic>Hemianopsia - pathology</topic><topic>Hemianopsia - physiopathology</topic><topic>Humans</topic><topic>Line bisection</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neglect syndromes</topic><topic>Neurologic Examination</topic><topic>Neuropsychological Tests</topic><topic>Ophthalmology</topic><topic>Organic mental disorders. 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Psychiatry</topic><topic>Saccades</topic><topic>Space</topic><topic>Space Perception - physiology</topic><topic>Vision</topic><topic>Visual Fields - physiology</topic><topic>Visual perception</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuhn, C.</creatorcontrib><creatorcontrib>Rosenthal, A.</creatorcontrib><creatorcontrib>Bublak, P.</creatorcontrib><creatorcontrib>Grotemeyer, K.H.</creatorcontrib><creatorcontrib>Reinhart, S.</creatorcontrib><creatorcontrib>Kerkhoff, G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuropsychologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuhn, C.</au><au>Rosenthal, A.</au><au>Bublak, P.</au><au>Grotemeyer, K.H.</au><au>Reinhart, S.</au><au>Kerkhoff, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does spatial cueing affect line bisection in chronic hemianopia?</atitle><jtitle>Neuropsychologia</jtitle><addtitle>Neuropsychologia</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>50</volume><issue>7</issue><spage>1656</spage><epage>1662</epage><pages>1656-1662</pages><issn>0028-3932</issn><eissn>1873-3514</eissn><coden>NUPSA6</coden><abstract>► Hemianopia (HA) is associated with a horizontal line bisection error (HLBE). ► We tested whether spatial-attentional cueing modulates the HLBE. ► 20 chronic HA patients with HLBE, 3 neglect patients and 20 controls were tested. ► Spatial cueing had no effect on HLBE in HA, but in leftsided neglect.
Patients with homonymous hemianopia often show a contralesional shift towards their blind field when bisecting horizontal lines (“hemianopic line bisection error”, HLBE). The reasons for this spatial bias are not well understood and debated. Cueing of spatial attention modulates line bisection significantly in patients with visuospatial neglect. Moreover, recent evidence showed that attention training significantly improves deficits of visual search in hemianopia. Here, we tested in 20 patients with chronic homonymous hemianopia (10 left-sided, 10 right-sided) without visual neglect, 10 healthy control subjects, 10 neurological control patients, and 3 patients with left visuospatial neglect and leftsided hemianopia whether spatial cueing influences the HLBE. Subjects indicated verbally the midpoint of horizontal lines in a computerized line bisection task under four experimental cue positions (cue far left, mid-left, mid-right or far-right within the horizontal line). All 20 hemianopic patients showed the typical HLBE towards their blind field, while the two control samples showed only a small but significant leftward shift (pseudoneglect). None of the 4 cueing manipulations had a significant effect on the HLBE in the hemianopic patients. Moreover, no differential effects of cueing on line bisection results were obtained when analyzed in lesion subgroups of hemianopic patients with circumscribed occipital lesions (N=8) as contrasted with patients having more extended (occipito-temporal or temporal) lesions (N=12). This null-effect contrasts with marked cueing effects observed in 3 neglect patients with left hemianopia in the same tasks, showing the principal efficacy of our cueing manipulation. These results argue against attentional explanations of the HLBE.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>22480681</pmid><doi>10.1016/j.neuropsychologia.2012.03.021</doi><tpages>7</tpages></addata></record> |
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| subjects | Action Adult Adult and adolescent clinical studies Aged Attention Biological and medical sciences Brain Chronic Disease Cues Diseases of visual field, optic nerve, optic chiasma and optic tracts Female Functional Laterality - physiology Hemianopia Hemianopsia - pathology Hemianopsia - physiopathology Humans Line bisection Male Medical sciences Middle Aged Neglect syndromes Neurologic Examination Neuropsychological Tests Ophthalmology Organic mental disorders. Neuropsychology Psychology. Psychoanalysis. Psychiatry Psychomotor Performance - physiology Psychopathology. Psychiatry Saccades Space Space Perception - physiology Vision Visual Fields - physiology Visual perception |
| title | Does spatial cueing affect line bisection in chronic hemianopia? |
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