Evaluation of selective tumor detection by clinical magnetic resonance imaging using antibody-conjugated superparamagnetic iron oxide

Active targeting by monoclonal antibodies (mAbs) combined with nanosize superparamagnetic iron oxide (SPIO) is a promising technology for magnetic resonance imaging (MRI) diagnosis. However, the clinical applicability of this technology has not been investigated using appropriate controls. It is imp...

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Veröffentlicht in:	Journal of controlled release 2012-05, Vol.159 (3), p.413-418
Hauptverfasser:	Koyama, Takayoshi, Shimura, Mari, Minemoto, Yuzuru, Nohara, Satoshi, Shibata, Sayaka, Iida, Yutaka, Iwashita, Shinki, Hasegawa, Masakatsu, Kurabayashi, Tohru, Hamada, Hirofumi, Kono, Kenji, Honda, Eiichi, Aoki, Ichio, Ishizaka, Yukihito
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - chemistry Biological and medical sciences Cell Line, Tumor Clinical 1.5 T-MRI CMDM Contrast Media - chemistry Controlled release Dextrans - chemistry Female Fluorescent Dyes - chemistry General pharmacology genetic background Immunoglobulin G - chemistry iron oxides Magnetic resonance imaging Magnetic Resonance Imaging - methods Magnetite Nanoparticles - chemistry Medical sciences Mice Mice, Inbred BALB C Monoclonal antibodies nanoparticles Neoplasm Transplantation neoplasms Neoplasms - diagnosis NIH 3T3 Cells Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments SPIO Therapeutic applications Tumor-targeting Tumors
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