Evaluation of selective tumor detection by clinical magnetic resonance imaging using antibody-conjugated superparamagnetic iron oxide
Active targeting by monoclonal antibodies (mAbs) combined with nanosize superparamagnetic iron oxide (SPIO) is a promising technology for magnetic resonance imaging (MRI) diagnosis. However, the clinical applicability of this technology has not been investigated using appropriate controls. It is imp...
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| Veröffentlicht in: | Journal of controlled release 2012-05, Vol.159 (3), p.413-418 |
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| creator | Koyama, Takayoshi Shimura, Mari Minemoto, Yuzuru Nohara, Satoshi Shibata, Sayaka Iida, Yutaka Iwashita, Shinki Hasegawa, Masakatsu Kurabayashi, Tohru Hamada, Hirofumi Kono, Kenji Honda, Eiichi Aoki, Ichio Ishizaka, Yukihito |
| description | Active targeting by monoclonal antibodies (mAbs) combined with nanosize superparamagnetic iron oxide (SPIO) is a promising technology for magnetic resonance imaging (MRI) diagnosis. However, the clinical applicability of this technology has not been investigated using appropriate controls. It is important to evaluate the targeting technology using widely used clinical 1.5-Tesla MRI in addition to the high-Tesla experimental MRI. In this study, we measured mAb-conjugated dextran-coated SPIO nanoparticles (CMDM) in vivo using clinical 1.5-Tesla MRI. MRI of tumor-bearing mice was performed using a simple comparison between positive and negative tumors derived from the same genetic background in each mouse. The system provided significant tumor-targeting specificity of the target tumor. To the best of our knowledge, this is the first report on the specific detection of target tumors by mAb-conjugated SPIO using clinical 1.5-Tesla MRI. Our observations provide clues for reliable active targeting using mAb-conjugated SPIO in clinical applications.
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| doi_str_mv | 10.1016/j.jconrel.2012.01.023 |
| format | Article |
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[Display omitted]</description><identifier>ISSN: 0168-3659</identifier><identifier>EISSN: 1873-4995</identifier><identifier>DOI: 10.1016/j.jconrel.2012.01.023</identifier><identifier>PMID: 22300621</identifier><identifier>CODEN: JCREEC</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Animals ; Antibodies, Monoclonal - chemistry ; Biological and medical sciences ; Cell Line, Tumor ; Clinical 1.5 T-MRI ; CMDM ; Contrast Media - chemistry ; Controlled release ; Dextrans - chemistry ; Female ; Fluorescent Dyes - chemistry ; General pharmacology ; genetic background ; Immunoglobulin G - chemistry ; iron oxides ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Magnetite Nanoparticles - chemistry ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Monoclonal antibodies ; nanoparticles ; Neoplasm Transplantation ; neoplasms ; Neoplasms - diagnosis ; NIH 3T3 Cells ; Particle Size ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; SPIO ; Therapeutic applications ; Tumor-targeting ; Tumors</subject><ispartof>Journal of controlled release, 2012-05, Vol.159 (3), p.413-418</ispartof><rights>2012 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c562t-41dc8936537f47aca7af807a9c80738923da61b4041de78310de7448654ff5dc3</citedby><cites>FETCH-LOGICAL-c562t-41dc8936537f47aca7af807a9c80738923da61b4041de78310de7448654ff5dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jconrel.2012.01.023$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25913122$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22300621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koyama, Takayoshi</creatorcontrib><creatorcontrib>Shimura, Mari</creatorcontrib><creatorcontrib>Minemoto, Yuzuru</creatorcontrib><creatorcontrib>Nohara, Satoshi</creatorcontrib><creatorcontrib>Shibata, Sayaka</creatorcontrib><creatorcontrib>Iida, Yutaka</creatorcontrib><creatorcontrib>Iwashita, Shinki</creatorcontrib><creatorcontrib>Hasegawa, Masakatsu</creatorcontrib><creatorcontrib>Kurabayashi, Tohru</creatorcontrib><creatorcontrib>Hamada, Hirofumi</creatorcontrib><creatorcontrib>Kono, Kenji</creatorcontrib><creatorcontrib>Honda, Eiichi</creatorcontrib><creatorcontrib>Aoki, Ichio</creatorcontrib><creatorcontrib>Ishizaka, Yukihito</creatorcontrib><title>Evaluation of selective tumor detection by clinical magnetic resonance imaging using antibody-conjugated superparamagnetic iron oxide</title><title>Journal of controlled release</title><addtitle>J Control Release</addtitle><description>Active targeting by monoclonal antibodies (mAbs) combined with nanosize superparamagnetic iron oxide (SPIO) is a promising technology for magnetic resonance imaging (MRI) diagnosis. However, the clinical applicability of this technology has not been investigated using appropriate controls. It is important to evaluate the targeting technology using widely used clinical 1.5-Tesla MRI in addition to the high-Tesla experimental MRI. In this study, we measured mAb-conjugated dextran-coated SPIO nanoparticles (CMDM) in vivo using clinical 1.5-Tesla MRI. MRI of tumor-bearing mice was performed using a simple comparison between positive and negative tumors derived from the same genetic background in each mouse. The system provided significant tumor-targeting specificity of the target tumor. To the best of our knowledge, this is the first report on the specific detection of target tumors by mAb-conjugated SPIO using clinical 1.5-Tesla MRI. Our observations provide clues for reliable active targeting using mAb-conjugated SPIO in clinical applications.
[Display omitted]</description><subject>Animals</subject><subject>Antibodies, Monoclonal - chemistry</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Clinical 1.5 T-MRI</subject><subject>CMDM</subject><subject>Contrast Media - chemistry</subject><subject>Controlled release</subject><subject>Dextrans - chemistry</subject><subject>Female</subject><subject>Fluorescent Dyes - chemistry</subject><subject>General pharmacology</subject><subject>genetic background</subject><subject>Immunoglobulin G - chemistry</subject><subject>iron oxides</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetite Nanoparticles - chemistry</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Monoclonal antibodies</subject><subject>nanoparticles</subject><subject>Neoplasm Transplantation</subject><subject>neoplasms</subject><subject>Neoplasms - diagnosis</subject><subject>NIH 3T3 Cells</subject><subject>Particle Size</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>SPIO</subject><subject>Therapeutic applications</subject><subject>Tumor-targeting</subject><subject>Tumors</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcuO0zAUhi0EYjqFRwC8QZpNiq-xs0JoNFykkVjArC3XOakcpXGxk4o-AO_NiVqGJWzOke3vXPz_hLzibMMZr9_1mz6kMcOwEYyLDeMbJuQTsuLWyEo1jX5KVsjZSta6uSLXpfSMMS2VeU6uhJCM1YKvyK-7ox9mP8U00tTRAgOEKR6BTvM-ZdrCtJzxcXuiYYhjDH6ge78bYYqBZihp9GMAGvEujjs6lyX6cYrb1J4qXLGfd36Clpb5APngs3-sjnkZ-jO28II86_xQ4OUlr8nDx7vvt5-r-6-fvtx-uK-CrsVUKd4G2-CHpOmU8cEb31lmfBMwStsI2fqabxVDEIyVnGFSytZadZ1ug1yTm3PfQ04_ZiiT28cSYBj8CGkujjOpLNdSmP9AObdKGGsR1Wc05FRKhs4dMuqRTwgtXO16dzHLLWY5xh2ahXWvLyPm7R7ax6o_7iDw9gL4grp3GaWO5S-nGy450mvy5sx1Pjm_y8g8fMNJmjFu6lotnd6fCUB1jxGyKyECGtfGjAa7NsV_LPsbiTPAnQ</recordid><startdate>20120510</startdate><enddate>20120510</enddate><creator>Koyama, Takayoshi</creator><creator>Shimura, Mari</creator><creator>Minemoto, Yuzuru</creator><creator>Nohara, Satoshi</creator><creator>Shibata, Sayaka</creator><creator>Iida, Yutaka</creator><creator>Iwashita, Shinki</creator><creator>Hasegawa, Masakatsu</creator><creator>Kurabayashi, Tohru</creator><creator>Hamada, Hirofumi</creator><creator>Kono, Kenji</creator><creator>Honda, Eiichi</creator><creator>Aoki, Ichio</creator><creator>Ishizaka, Yukihito</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20120510</creationdate><title>Evaluation of selective tumor detection by clinical magnetic resonance imaging using antibody-conjugated superparamagnetic iron oxide</title><author>Koyama, Takayoshi ; Shimura, Mari ; Minemoto, Yuzuru ; Nohara, Satoshi ; Shibata, Sayaka ; Iida, Yutaka ; Iwashita, Shinki ; Hasegawa, Masakatsu ; Kurabayashi, Tohru ; Hamada, Hirofumi ; Kono, Kenji ; Honda, Eiichi ; Aoki, Ichio ; Ishizaka, Yukihito</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c562t-41dc8936537f47aca7af807a9c80738923da61b4041de78310de7448654ff5dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal - chemistry</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>Clinical 1.5 T-MRI</topic><topic>CMDM</topic><topic>Contrast Media - chemistry</topic><topic>Controlled release</topic><topic>Dextrans - chemistry</topic><topic>Female</topic><topic>Fluorescent Dyes - chemistry</topic><topic>General pharmacology</topic><topic>genetic background</topic><topic>Immunoglobulin G - chemistry</topic><topic>iron oxides</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetite Nanoparticles - chemistry</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Monoclonal antibodies</topic><topic>nanoparticles</topic><topic>Neoplasm Transplantation</topic><topic>neoplasms</topic><topic>Neoplasms - diagnosis</topic><topic>NIH 3T3 Cells</topic><topic>Particle Size</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. 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However, the clinical applicability of this technology has not been investigated using appropriate controls. It is important to evaluate the targeting technology using widely used clinical 1.5-Tesla MRI in addition to the high-Tesla experimental MRI. In this study, we measured mAb-conjugated dextran-coated SPIO nanoparticles (CMDM) in vivo using clinical 1.5-Tesla MRI. MRI of tumor-bearing mice was performed using a simple comparison between positive and negative tumors derived from the same genetic background in each mouse. The system provided significant tumor-targeting specificity of the target tumor. To the best of our knowledge, this is the first report on the specific detection of target tumors by mAb-conjugated SPIO using clinical 1.5-Tesla MRI. Our observations provide clues for reliable active targeting using mAb-conjugated SPIO in clinical applications.
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| ispartof | Journal of controlled release, 2012-05, Vol.159 (3), p.413-418 |
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| subjects | Animals Antibodies, Monoclonal - chemistry Biological and medical sciences Cell Line, Tumor Clinical 1.5 T-MRI CMDM Contrast Media - chemistry Controlled release Dextrans - chemistry Female Fluorescent Dyes - chemistry General pharmacology genetic background Immunoglobulin G - chemistry iron oxides Magnetic resonance imaging Magnetic Resonance Imaging - methods Magnetite Nanoparticles - chemistry Medical sciences Mice Mice, Inbred BALB C Monoclonal antibodies nanoparticles Neoplasm Transplantation neoplasms Neoplasms - diagnosis NIH 3T3 Cells Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments SPIO Therapeutic applications Tumor-targeting Tumors |
| title | Evaluation of selective tumor detection by clinical magnetic resonance imaging using antibody-conjugated superparamagnetic iron oxide |
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