Metabolic engineering of I2-oxidation in Penicillium chrysogenum for improved semi-synthetic cephalosporin biosynthesis

Industrial production of semi-synthetic cephalosporins by Penicillium chrysogenum requires supplementation of the growth media with the side-chain precursor adipic acid. In glucose-limited chemostat cultures of P. chrysogenum, up to 88% of the consumed adipic acid was not recovered in cephalosporin-...

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Veröffentlicht in:	Metabolic engineering 2012-07, Vol.14 (4), p.437-448
Hauptverfasser:	Veiga, TAcnia, Gombert, Andreas K, Landes, Nils, Verhoeven, Maarten D, Kiel, Jan AKW, Krikken, Arjen M, Nijland, Jeroen G, Touw, Hesselien, Luttik, Marijke AH, van der Toorn, John C, Driessen, Arnold JM, Bovenberg, Roel AL, van den Berg, Marco A, van der Klei, Ida J, Pronk, Jack T, Daran, Jean-Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl-CoA dehydrogenase Acyl-CoA oxidase adipic acid Carbon Cephalosporins Continuous culture dehydrogenase Economics Energy Enzymes Gene expression metabolic engineering Mitochondria Penicillium chrysogenum Peroxisomes Supplementation
Online-Zugang:	Volltext
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