Exploration of the binding proteins of perfluorooctane sulfonate by a T7 phage display screen

Perfluorooctane sulfonate (PFOS) is a pollutant widely found throughout nature and is toxic to animals. We created a PFOS analogue on a polyethylene glycol polyacrylamide copolymer and isolated peptides that preferentially bound the PFOS analogue using a T7 phage display system. Bioinformatic analys...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2012-07, Vol.20 (13), p.3985-3990
Hauptverfasser:	Miyano, Yuka, Tsukuda, Senko, Sakimoto, Ippei, Takeuchi, Ryo, Shimura, Satomi, Takahashi, Noriyuki, Kusayanagi, Tomoe, Takakusagi, Yoichi, Okado, Mami, Matsumoto, Yuki, Takakusagi, Kaori, Takeuchi, Toshifumi, Kamisuki, Shinji, Nakazaki, Atsuo, Ohta, Keisuke, Miura, Masahiko, Kuramochi, Kouji, Mizushina, Yoshiyuki, Kobayashi, Susumu, Sugawara, Fumio, Sakaguchi, Kengo
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkanesulfonic Acids - chemistry Alkanesulfonic Acids - metabolism Amino Acid Sequence Animals Bioinformatics Biological and medical sciences Biosensors Carrier Proteins - metabolism CD14 CD14 antigen Cell Line Computational Biology Computer programs Copolymers Differentiation Fluorocarbons - chemistry Fluorocarbons - metabolism Humans Lipopolysaccharide Receptors - genetics Lipopolysaccharide Receptors - metabolism Macrophages Medical sciences Mice Monocytes Peptide Library Perfluorooctane sulfonate Phage display Pharmacology. Drug treatments Pollutants Polyethylene glycol Recombinant Proteins - genetics Recombinant Proteins - metabolism RELIC Software Solid-phase synthesis Surface Plasmon Resonance Tumor Necrosis Factor-alpha - metabolism
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