Discovery and evaluation of selective N-type calcium channel blockers: 6-Unsubstituted-1,4-dihydropyridine-5-carboxylic acid derivatives

The structure–activity relationship study on 6-unsubstituted-1,4-dihydropyridine derivatives and 2,6-dihydro-1,4-dihydropyridine derivatives are reported as selective N-type calcium channel blockers over L-type calcium channel. A structure–activity relationship study of 6-unsubstituted-1,4-dihydropy...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2012-06, Vol.22 (11), p.3639-3642
Hauptverfasser:	Yamamoto, Takashi, Niwa, Seiji, Tokumasu, Munetaka, Onishi, Tomoyuki, Ohno, Seiji, Hagihara, Masako, Koganei, Hajime, Fujita, Shin-ichi, Takeda, Tomoko, Saitou, Yuki, Iwayama, Satoshi, Takahara, Akira, Iwata, Seinosuke, Shoji, Masataka
Format:	Artikel
Sprache:	eng
Schlagworte:	1,4-Dihydropyridine derivative Administration, Oral Analgesics Analgesics - chemical synthesis Analgesics - chemistry Analgesics - pharmacology Animals Biological and medical sciences calcium channel blockers Calcium Channel Blockers - chemical synthesis Calcium Channel Blockers - chemistry Calcium Channel Blockers - pharmacology calcium channels Calcium Channels, N-Type - chemistry Calcium Channels, N-Type - metabolism Carboxylic Acids - chemical synthesis Carboxylic Acids - chemistry Carboxylic Acids - pharmacology Dihydropyridines - chemistry Drug Evaluation, Preclinical Formaldehyde - toxicity Medical sciences N-Type calcium channel blocker Pain Measurement - drug effects Pharmacology. Drug treatments Rats Structure-Activity Relationship Structure–activity relationships
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