Retinal projections and neurochemical characterization of the pregeniculate nucleus of the common marmoset (Callithrix jacchus)

► Neurochemical characterization of the pregeniculate nucleus of the marmoset. ► Subdivision of the pregeniculate nucleus based on cell cytoarchitecture and neurochemical content. ► Use of tracers to map the neural retinal innervation in the pregeniculate nucleus. ► Comparison between the primate pr...

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Veröffentlicht in:Journal of chemical neuroanatomy 2012-05, Vol.44 (1), p.34-44
Hauptverfasser: Lima, Ruthnaldo R.M., Pinato, Luciana, Nascimento, Rayane B.S., Engelberth, Rovena Clara G.J., Nascimento, Expedito S., Cavalcante, Judney C., Britto, Luiz R.G., Costa, Miriam S.M.O., Cavalcante, Jeferson S.
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container_issue 1
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container_title Journal of chemical neuroanatomy
container_volume 44
creator Lima, Ruthnaldo R.M.
Pinato, Luciana
Nascimento, Rayane B.S.
Engelberth, Rovena Clara G.J.
Nascimento, Expedito S.
Cavalcante, Judney C.
Britto, Luiz R.G.
Costa, Miriam S.M.O.
Cavalcante, Jeferson S.
description ► Neurochemical characterization of the pregeniculate nucleus of the marmoset. ► Subdivision of the pregeniculate nucleus based on cell cytoarchitecture and neurochemical content. ► Use of tracers to map the neural retinal innervation in the pregeniculate nucleus. ► Comparison between the primate pregeniculate nucleus and its homologous structure in rodents, the intergeniculate leaflet. In mammals, the suprachiasmatic nucleus (SCN) and the intergeniculate leaflet (IGL) are the main components of the circadian timing system. The SCN is the site of the endogenous biological clock that generates rhythms and synchronizes them to environmental cues. The IGL is a key structure that modulates SCN activity and is responsible for the transmission of non-photic information to the SCN, thus participating in the integration between photic and non-photic stimuli. Both the SCN and IGL receive projections of retinal ganglion cells and the IGL is connected to the SCN through the geniculohypothalamic tract. Little is known about these structures in the primate brain and the pregeniculate nucleus (PGN) has been suggested to be the primate equivalent of the rodent IGL. The aim of this study was to characterize the PGN of a primate, the common marmoset (Callithrix jacchus), and to analyze its retinal afferents. Here, the marmoset PGN was found to be organized into three subsectors based on neuronal size, pattern of retinal projections, and the distribution of neuropeptide Y-, GAD-, serotonin-, enkephalin- and substance P-labeled terminals. This pattern indicates that the marmoset PGN is equivalent to the IGL. This detailed description contributes to the understanding of the circadian timing system in this primate species considering the importance of the IGL within the context of circadian regulation.
doi_str_mv 10.1016/j.jchemneu.2012.04.001
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In mammals, the suprachiasmatic nucleus (SCN) and the intergeniculate leaflet (IGL) are the main components of the circadian timing system. The SCN is the site of the endogenous biological clock that generates rhythms and synchronizes them to environmental cues. The IGL is a key structure that modulates SCN activity and is responsible for the transmission of non-photic information to the SCN, thus participating in the integration between photic and non-photic stimuli. Both the SCN and IGL receive projections of retinal ganglion cells and the IGL is connected to the SCN through the geniculohypothalamic tract. Little is known about these structures in the primate brain and the pregeniculate nucleus (PGN) has been suggested to be the primate equivalent of the rodent IGL. The aim of this study was to characterize the PGN of a primate, the common marmoset (Callithrix jacchus), and to analyze its retinal afferents. 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In mammals, the suprachiasmatic nucleus (SCN) and the intergeniculate leaflet (IGL) are the main components of the circadian timing system. The SCN is the site of the endogenous biological clock that generates rhythms and synchronizes them to environmental cues. The IGL is a key structure that modulates SCN activity and is responsible for the transmission of non-photic information to the SCN, thus participating in the integration between photic and non-photic stimuli. Both the SCN and IGL receive projections of retinal ganglion cells and the IGL is connected to the SCN through the geniculohypothalamic tract. Little is known about these structures in the primate brain and the pregeniculate nucleus (PGN) has been suggested to be the primate equivalent of the rodent IGL. The aim of this study was to characterize the PGN of a primate, the common marmoset (Callithrix jacchus), and to analyze its retinal afferents. 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subjects Anatomy
Animals
Brain
Brain architecture
Callithrix - anatomy & histology
Callithrix jacchus
Cholera toxin
Circadian Rhythm - physiology
Circadian rhythms
Circadian timing system
CLOCK protein
Enkephalins - metabolism
Glutamate Decarboxylase - metabolism
Immunohistochemical
Immunohistochemistry
Integration
Intergeniculate nucleus
Male
Neuropeptide Y - metabolism
Neuropeptides
Neurotransmission
Phenotype
Pregeniculate nucleus
Primate
Primates
Retina
Retina - anatomy & histology
Retina - cytology
Retina - metabolism
Retinal ganglion cells
Sensory neurons
Serotonin - metabolism
Substance P - metabolism
Suprachiasmatic nucleus
Suprachiasmatic Nucleus - physiology
Thalamic Nuclei - anatomy & histology
Thalamic Nuclei - cytology
Thalamic Nuclei - metabolism
Visual Pathways - anatomy & histology
Visual Pathways - metabolism
title Retinal projections and neurochemical characterization of the pregeniculate nucleus of the common marmoset (Callithrix jacchus)
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