Retinal projections and neurochemical characterization of the pregeniculate nucleus of the common marmoset (Callithrix jacchus)
► Neurochemical characterization of the pregeniculate nucleus of the marmoset. ► Subdivision of the pregeniculate nucleus based on cell cytoarchitecture and neurochemical content. ► Use of tracers to map the neural retinal innervation in the pregeniculate nucleus. ► Comparison between the primate pr...
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creator | Lima, Ruthnaldo R.M. Pinato, Luciana Nascimento, Rayane B.S. Engelberth, Rovena Clara G.J. Nascimento, Expedito S. Cavalcante, Judney C. Britto, Luiz R.G. Costa, Miriam S.M.O. Cavalcante, Jeferson S. |
description | ► Neurochemical characterization of the pregeniculate nucleus of the marmoset. ► Subdivision of the pregeniculate nucleus based on cell cytoarchitecture and neurochemical content. ► Use of tracers to map the neural retinal innervation in the pregeniculate nucleus. ► Comparison between the primate pregeniculate nucleus and its homologous structure in rodents, the intergeniculate leaflet.
In mammals, the suprachiasmatic nucleus (SCN) and the intergeniculate leaflet (IGL) are the main components of the circadian timing system. The SCN is the site of the endogenous biological clock that generates rhythms and synchronizes them to environmental cues. The IGL is a key structure that modulates SCN activity and is responsible for the transmission of non-photic information to the SCN, thus participating in the integration between photic and non-photic stimuli. Both the SCN and IGL receive projections of retinal ganglion cells and the IGL is connected to the SCN through the geniculohypothalamic tract. Little is known about these structures in the primate brain and the pregeniculate nucleus (PGN) has been suggested to be the primate equivalent of the rodent IGL. The aim of this study was to characterize the PGN of a primate, the common marmoset (Callithrix jacchus), and to analyze its retinal afferents. Here, the marmoset PGN was found to be organized into three subsectors based on neuronal size, pattern of retinal projections, and the distribution of neuropeptide Y-, GAD-, serotonin-, enkephalin- and substance P-labeled terminals. This pattern indicates that the marmoset PGN is equivalent to the IGL. This detailed description contributes to the understanding of the circadian timing system in this primate species considering the importance of the IGL within the context of circadian regulation. |
doi_str_mv | 10.1016/j.jchemneu.2012.04.001 |
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In mammals, the suprachiasmatic nucleus (SCN) and the intergeniculate leaflet (IGL) are the main components of the circadian timing system. The SCN is the site of the endogenous biological clock that generates rhythms and synchronizes them to environmental cues. The IGL is a key structure that modulates SCN activity and is responsible for the transmission of non-photic information to the SCN, thus participating in the integration between photic and non-photic stimuli. Both the SCN and IGL receive projections of retinal ganglion cells and the IGL is connected to the SCN through the geniculohypothalamic tract. Little is known about these structures in the primate brain and the pregeniculate nucleus (PGN) has been suggested to be the primate equivalent of the rodent IGL. The aim of this study was to characterize the PGN of a primate, the common marmoset (Callithrix jacchus), and to analyze its retinal afferents. Here, the marmoset PGN was found to be organized into three subsectors based on neuronal size, pattern of retinal projections, and the distribution of neuropeptide Y-, GAD-, serotonin-, enkephalin- and substance P-labeled terminals. This pattern indicates that the marmoset PGN is equivalent to the IGL. This detailed description contributes to the understanding of the circadian timing system in this primate species considering the importance of the IGL within the context of circadian regulation.</description><identifier>ISSN: 0891-0618</identifier><identifier>EISSN: 1873-6300</identifier><identifier>DOI: 10.1016/j.jchemneu.2012.04.001</identifier><identifier>PMID: 22531294</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Anatomy ; Animals ; Brain ; Brain architecture ; Callithrix - anatomy & histology ; Callithrix jacchus ; Cholera toxin ; Circadian Rhythm - physiology ; Circadian rhythms ; Circadian timing system ; CLOCK protein ; Enkephalins - metabolism ; Glutamate Decarboxylase - metabolism ; Immunohistochemical ; Immunohistochemistry ; Integration ; Intergeniculate nucleus ; Male ; Neuropeptide Y - metabolism ; Neuropeptides ; Neurotransmission ; Phenotype ; Pregeniculate nucleus ; Primate ; Primates ; Retina ; Retina - anatomy & histology ; Retina - cytology ; Retina - metabolism ; Retinal ganglion cells ; Sensory neurons ; Serotonin - metabolism ; Substance P - metabolism ; Suprachiasmatic nucleus ; Suprachiasmatic Nucleus - physiology ; Thalamic Nuclei - anatomy & histology ; Thalamic Nuclei - cytology ; Thalamic Nuclei - metabolism ; Visual Pathways - anatomy & histology ; Visual Pathways - metabolism</subject><ispartof>Journal of chemical neuroanatomy, 2012-05, Vol.44 (1), p.34-44</ispartof><rights>2012 Elsevier B.V.</rights><rights>Copyright © 2012 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-a400b511cda7d078b076931a1e9ec05507f7276ed00199b9e79775e7eb590c1b3</citedby><cites>FETCH-LOGICAL-c401t-a400b511cda7d078b076931a1e9ec05507f7276ed00199b9e79775e7eb590c1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jchemneu.2012.04.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22531294$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lima, Ruthnaldo R.M.</creatorcontrib><creatorcontrib>Pinato, Luciana</creatorcontrib><creatorcontrib>Nascimento, Rayane B.S.</creatorcontrib><creatorcontrib>Engelberth, Rovena Clara G.J.</creatorcontrib><creatorcontrib>Nascimento, Expedito S.</creatorcontrib><creatorcontrib>Cavalcante, Judney C.</creatorcontrib><creatorcontrib>Britto, Luiz R.G.</creatorcontrib><creatorcontrib>Costa, Miriam S.M.O.</creatorcontrib><creatorcontrib>Cavalcante, Jeferson S.</creatorcontrib><title>Retinal projections and neurochemical characterization of the pregeniculate nucleus of the common marmoset (Callithrix jacchus)</title><title>Journal of chemical neuroanatomy</title><addtitle>J Chem Neuroanat</addtitle><description>► Neurochemical characterization of the pregeniculate nucleus of the marmoset. ► Subdivision of the pregeniculate nucleus based on cell cytoarchitecture and neurochemical content. ► Use of tracers to map the neural retinal innervation in the pregeniculate nucleus. ► Comparison between the primate pregeniculate nucleus and its homologous structure in rodents, the intergeniculate leaflet.
In mammals, the suprachiasmatic nucleus (SCN) and the intergeniculate leaflet (IGL) are the main components of the circadian timing system. The SCN is the site of the endogenous biological clock that generates rhythms and synchronizes them to environmental cues. The IGL is a key structure that modulates SCN activity and is responsible for the transmission of non-photic information to the SCN, thus participating in the integration between photic and non-photic stimuli. Both the SCN and IGL receive projections of retinal ganglion cells and the IGL is connected to the SCN through the geniculohypothalamic tract. Little is known about these structures in the primate brain and the pregeniculate nucleus (PGN) has been suggested to be the primate equivalent of the rodent IGL. The aim of this study was to characterize the PGN of a primate, the common marmoset (Callithrix jacchus), and to analyze its retinal afferents. Here, the marmoset PGN was found to be organized into three subsectors based on neuronal size, pattern of retinal projections, and the distribution of neuropeptide Y-, GAD-, serotonin-, enkephalin- and substance P-labeled terminals. This pattern indicates that the marmoset PGN is equivalent to the IGL. This detailed description contributes to the understanding of the circadian timing system in this primate species considering the importance of the IGL within the context of circadian regulation.</description><subject>Anatomy</subject><subject>Animals</subject><subject>Brain</subject><subject>Brain architecture</subject><subject>Callithrix - anatomy & histology</subject><subject>Callithrix jacchus</subject><subject>Cholera toxin</subject><subject>Circadian Rhythm - physiology</subject><subject>Circadian rhythms</subject><subject>Circadian timing system</subject><subject>CLOCK protein</subject><subject>Enkephalins - metabolism</subject><subject>Glutamate Decarboxylase - metabolism</subject><subject>Immunohistochemical</subject><subject>Immunohistochemistry</subject><subject>Integration</subject><subject>Intergeniculate nucleus</subject><subject>Male</subject><subject>Neuropeptide Y - metabolism</subject><subject>Neuropeptides</subject><subject>Neurotransmission</subject><subject>Phenotype</subject><subject>Pregeniculate nucleus</subject><subject>Primate</subject><subject>Primates</subject><subject>Retina</subject><subject>Retina - anatomy & histology</subject><subject>Retina - cytology</subject><subject>Retina - metabolism</subject><subject>Retinal ganglion cells</subject><subject>Sensory neurons</subject><subject>Serotonin - metabolism</subject><subject>Substance P - metabolism</subject><subject>Suprachiasmatic nucleus</subject><subject>Suprachiasmatic Nucleus - physiology</subject><subject>Thalamic Nuclei - anatomy & histology</subject><subject>Thalamic Nuclei - cytology</subject><subject>Thalamic Nuclei - metabolism</subject><subject>Visual Pathways - anatomy & histology</subject><subject>Visual Pathways - metabolism</subject><issn>0891-0618</issn><issn>1873-6300</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1v1DAQxS0EotvCv1DlWA4JM_mw4xtoVT6kSkgIzpYzmSWOkrjYCSpc-Nfxartc4eTD_N48v3lCXCMUCChfj8VIA88Lb0UJWBZQFwD4ROywVVUuK4CnYgetxhwkthfiMsYxAU1Vy-fioiybCktd78Tvz7y6xU7ZffAj0-r8EjO79FnaHPzRwlGa0mCDpZWD-2WPTOYP2TpwUvE3Xhxtk105WzaaeIvnIfl5Tuhsw-wjr9nN3k6TW4fgHrLREg1bfPVCPDvYKfLLx_dKfH13-2X_Ib_79P7j_u1dTjXgmtsaoGsQqbeqB9V2oKSu0CJrJmgaUAdVKsl9yqh1p1lppRpW3DUaCLvqStyc9qac3zeOq5ldJJ4mu7DfokGo6hYRGv0faCllW0FdJlSeUAo-xsAHcx9cyvszQebYkxnNuSdz7MlAbdIXk_D60WPrZu7_ys7FJODNCeB0lB-Og4nkeCHuXUg1md67f3n8AQrxqQw</recordid><startdate>201205</startdate><enddate>201205</enddate><creator>Lima, Ruthnaldo R.M.</creator><creator>Pinato, Luciana</creator><creator>Nascimento, Rayane B.S.</creator><creator>Engelberth, Rovena Clara G.J.</creator><creator>Nascimento, Expedito S.</creator><creator>Cavalcante, Judney C.</creator><creator>Britto, Luiz R.G.</creator><creator>Costa, Miriam S.M.O.</creator><creator>Cavalcante, Jeferson S.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201205</creationdate><title>Retinal projections and neurochemical characterization of the pregeniculate nucleus of the common marmoset (Callithrix jacchus)</title><author>Lima, Ruthnaldo R.M. ; Pinato, Luciana ; Nascimento, Rayane B.S. ; Engelberth, Rovena Clara G.J. ; Nascimento, Expedito S. ; Cavalcante, Judney C. ; Britto, Luiz R.G. ; Costa, Miriam S.M.O. ; Cavalcante, Jeferson S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-a400b511cda7d078b076931a1e9ec05507f7276ed00199b9e79775e7eb590c1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Anatomy</topic><topic>Animals</topic><topic>Brain</topic><topic>Brain architecture</topic><topic>Callithrix - anatomy & histology</topic><topic>Callithrix jacchus</topic><topic>Cholera toxin</topic><topic>Circadian Rhythm - physiology</topic><topic>Circadian rhythms</topic><topic>Circadian timing system</topic><topic>CLOCK protein</topic><topic>Enkephalins - metabolism</topic><topic>Glutamate Decarboxylase - metabolism</topic><topic>Immunohistochemical</topic><topic>Immunohistochemistry</topic><topic>Integration</topic><topic>Intergeniculate nucleus</topic><topic>Male</topic><topic>Neuropeptide Y - metabolism</topic><topic>Neuropeptides</topic><topic>Neurotransmission</topic><topic>Phenotype</topic><topic>Pregeniculate nucleus</topic><topic>Primate</topic><topic>Primates</topic><topic>Retina</topic><topic>Retina - anatomy & histology</topic><topic>Retina - cytology</topic><topic>Retina - metabolism</topic><topic>Retinal ganglion cells</topic><topic>Sensory neurons</topic><topic>Serotonin - metabolism</topic><topic>Substance P - metabolism</topic><topic>Suprachiasmatic nucleus</topic><topic>Suprachiasmatic Nucleus - physiology</topic><topic>Thalamic Nuclei - anatomy & histology</topic><topic>Thalamic Nuclei - cytology</topic><topic>Thalamic Nuclei - metabolism</topic><topic>Visual Pathways - anatomy & histology</topic><topic>Visual Pathways - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lima, Ruthnaldo R.M.</creatorcontrib><creatorcontrib>Pinato, Luciana</creatorcontrib><creatorcontrib>Nascimento, Rayane B.S.</creatorcontrib><creatorcontrib>Engelberth, Rovena Clara G.J.</creatorcontrib><creatorcontrib>Nascimento, Expedito S.</creatorcontrib><creatorcontrib>Cavalcante, Judney C.</creatorcontrib><creatorcontrib>Britto, Luiz R.G.</creatorcontrib><creatorcontrib>Costa, Miriam S.M.O.</creatorcontrib><creatorcontrib>Cavalcante, Jeferson S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of chemical neuroanatomy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lima, Ruthnaldo R.M.</au><au>Pinato, Luciana</au><au>Nascimento, Rayane B.S.</au><au>Engelberth, Rovena Clara G.J.</au><au>Nascimento, Expedito S.</au><au>Cavalcante, Judney C.</au><au>Britto, Luiz R.G.</au><au>Costa, Miriam S.M.O.</au><au>Cavalcante, Jeferson S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinal projections and neurochemical characterization of the pregeniculate nucleus of the common marmoset (Callithrix jacchus)</atitle><jtitle>Journal of chemical neuroanatomy</jtitle><addtitle>J Chem Neuroanat</addtitle><date>2012-05</date><risdate>2012</risdate><volume>44</volume><issue>1</issue><spage>34</spage><epage>44</epage><pages>34-44</pages><issn>0891-0618</issn><eissn>1873-6300</eissn><abstract>► Neurochemical characterization of the pregeniculate nucleus of the marmoset. ► Subdivision of the pregeniculate nucleus based on cell cytoarchitecture and neurochemical content. ► Use of tracers to map the neural retinal innervation in the pregeniculate nucleus. ► Comparison between the primate pregeniculate nucleus and its homologous structure in rodents, the intergeniculate leaflet.
In mammals, the suprachiasmatic nucleus (SCN) and the intergeniculate leaflet (IGL) are the main components of the circadian timing system. The SCN is the site of the endogenous biological clock that generates rhythms and synchronizes them to environmental cues. The IGL is a key structure that modulates SCN activity and is responsible for the transmission of non-photic information to the SCN, thus participating in the integration between photic and non-photic stimuli. Both the SCN and IGL receive projections of retinal ganglion cells and the IGL is connected to the SCN through the geniculohypothalamic tract. Little is known about these structures in the primate brain and the pregeniculate nucleus (PGN) has been suggested to be the primate equivalent of the rodent IGL. The aim of this study was to characterize the PGN of a primate, the common marmoset (Callithrix jacchus), and to analyze its retinal afferents. Here, the marmoset PGN was found to be organized into three subsectors based on neuronal size, pattern of retinal projections, and the distribution of neuropeptide Y-, GAD-, serotonin-, enkephalin- and substance P-labeled terminals. This pattern indicates that the marmoset PGN is equivalent to the IGL. This detailed description contributes to the understanding of the circadian timing system in this primate species considering the importance of the IGL within the context of circadian regulation.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>22531294</pmid><doi>10.1016/j.jchemneu.2012.04.001</doi><tpages>11</tpages></addata></record> |
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subjects | Anatomy Animals Brain Brain architecture Callithrix - anatomy & histology Callithrix jacchus Cholera toxin Circadian Rhythm - physiology Circadian rhythms Circadian timing system CLOCK protein Enkephalins - metabolism Glutamate Decarboxylase - metabolism Immunohistochemical Immunohistochemistry Integration Intergeniculate nucleus Male Neuropeptide Y - metabolism Neuropeptides Neurotransmission Phenotype Pregeniculate nucleus Primate Primates Retina Retina - anatomy & histology Retina - cytology Retina - metabolism Retinal ganglion cells Sensory neurons Serotonin - metabolism Substance P - metabolism Suprachiasmatic nucleus Suprachiasmatic Nucleus - physiology Thalamic Nuclei - anatomy & histology Thalamic Nuclei - cytology Thalamic Nuclei - metabolism Visual Pathways - anatomy & histology Visual Pathways - metabolism |
title | Retinal projections and neurochemical characterization of the pregeniculate nucleus of the common marmoset (Callithrix jacchus) |
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