Aging redistributes medial prefrontal neuronal excitability and impedes extinction of trace fear conditioning

Abstract Cognitive flexibility is critical for survival and reflects the malleability of the central nervous system (CNS) in response to changing environmental demands. Normal aging results in difficulties modifying established behaviors, which may involve medial prefrontal cortex (mPFC) dysfunction...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neurobiology of aging 2012-08, Vol.33 (8), p.1744-1757
Hauptverfasser:	Kaczorowski, Catherine C, Davis, Scott J, Moyer, James R
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - physiology Animals Burst spiking Central nervous system Cognitive ability Cognitive flexibility Conditioning, Classical - physiology Cortex (prefrontal) Excitability Extinction Extinction, Psychological - physiology Fear - physiology Fear conditioning Firing pattern Infralimbic Internal Medicine Intrinsic excitability Male Nerve Net - physiology Nervous system Neurology Neurons Prefrontal Cortex - physiology Prelimbic Rats Rats, Inbred F344 Regular spiking Trace fear conditioning
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!