Patients on a combined antiretroviral therapy after maraviroc clinical test show no immunovirological impairment

► Maraviroc clinical test (MCT) as a method to select candidate patients to be treated with CCR5-antagonists. ► Advantages of MCT compared with other tropism assays. ► Long-term outcome of patients starting cART after MCT shows immunovirological efficacy. ► Tropism analysis during MCT shows no clini...

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Veröffentlicht in:Antiviral research 2012-09, Vol.95 (3), p.207-211
Hauptverfasser: Genebat, Miguel, Pulido, Ildefonso, Romero-Sánchez, M. Concepción, González-Serna, Alejandro, Ferrando-Martínez, Sara, Machmach, Kawthar, Pacheco, Yolanda M., Muñoz-Fernández, Mª Ángeles, Ruiz-Mateos, Ezequiel, Leal, Manuel
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Sprache:eng
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Zusammenfassung:► Maraviroc clinical test (MCT) as a method to select candidate patients to be treated with CCR5-antagonists. ► Advantages of MCT compared with other tropism assays. ► Long-term outcome of patients starting cART after MCT shows immunovirological efficacy. ► Tropism analysis during MCT shows no clinically relevant tropism change after short-term maraviroc monotherapy. The maraviroc clinical test (MCT) is a clinical approach to establish the indication of maraviroc treatment. In this study, we analysed the long-term outcome of patients receiving a combined antiretroviral therapy (cART) selected according to MCT results. Ninety-two consecutive HIV-infected patients underwent MCT. A virological response (
ISSN:0166-3542
1872-9096
DOI:10.1016/j.antiviral.2012.06.007