Low Concentration Detergent Sclerosants Induce Platelet Activation but Inhibit Aggregation due to Suppression of GPIIb/IIIa Activation in vitro

Abstract Introduction Sclerotherapy is associated with thromboembolic and ischemic neurological adverse events but the effects of sclerosants on platelet function are unknown. The aim of this study was to investigate the in vitro effects of detergent sclerosants Sodium Tetradecyl Sulphate (STS) and...

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Veröffentlicht in:	Thrombosis research 2012-09, Vol.130 (3), p.472-478
Hauptverfasser:	Parsi, Kurosh, Connor, David E, Pilotelle, Anne, Low, Joyce, Ma, David D.F, Joseph, Joanne E
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood and lymphatic vessels Blood. Blood coagulation. Reticuloendothelial system Cardiology. Vascular system Cells, Cultured Detergent Sclerosants Detergents - administration & dosage Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Dose-Response Relationship, Drug Hematology, Oncology and Palliative Medicine Humans Medical sciences Pharmacology. Drug treatments Platelet activation Platelet Activation - drug effects Platelet Activation - physiology Platelet aggregation Platelet Aggregation - drug effects Platelet Aggregation - physiology Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors Platelet glycoprotein IIb/IIIa complex Platelet microparticles Platelets Polyethylene Glycols - administration & dosage Sclerosing Solutions - administration & dosage Sodium Tetradecyl Sulfate - administration & dosage
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