Mitochondria of trained skeletal muscle are protected from deleterious effects of statins

Introduction: Statins are associated with adverse skeletal muscle effects. Our objective was to determine if muscular adaptations following exercise training prevented deleterious effects of atorvastatin in glycolytic skeletal muscle. Methods: Twenty rats were divided into 2 groups: a control group...

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Veröffentlicht in:	Muscle & nerve 2012-09, Vol.46 (3), p.367-373
Hauptverfasser:	Bouitbir, Jamal, Daussin, Frédéric, Charles, Anne-Laure, Rasseneur, Laurence, Dufour, Stéphane, Richard, Ruddy, Piquard, François, Geny, Bernard, Zoll, Joffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atorvastatin Calcium Biological and medical sciences Electrodiagnosis. Electric activity recording exercise training Fundamental and applied biological sciences. Psychology glycolytic muscle Heptanoic Acids - adverse effects Heptanoic Acids - pharmacology Hydrogen Peroxide - metabolism Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Mitochondria, Muscle - drug effects Mitochondria, Muscle - metabolism Mitochondria, Muscle - physiology mitochondrial respiration Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscle, Skeletal - physiology Nervous system oxidative stress Oxygen Consumption - drug effects Oxygen Consumption - physiology Physical Conditioning, Animal - physiology Physical Endurance - physiology Pyrroles - adverse effects Pyrroles - pharmacology Rats Rats, Wistar Reactive Oxygen Species - metabolism statins Striated muscle. Tendons Vertebrates: osteoarticular system, musculoskeletal system
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