Mitochondria of trained skeletal muscle are protected from deleterious effects of statins
Introduction: Statins are associated with adverse skeletal muscle effects. Our objective was to determine if muscular adaptations following exercise training prevented deleterious effects of atorvastatin in glycolytic skeletal muscle. Methods: Twenty rats were divided into 2 groups: a control group...
Gespeichert in:
| Veröffentlicht in: | Muscle & nerve 2012-09, Vol.46 (3), p.367-373 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 373 |
|---|---|
| container_issue | 3 |
| container_start_page | 367 |
| container_title | Muscle & nerve |
| container_volume | 46 |
| creator | Bouitbir, Jamal Daussin, Frédéric Charles, Anne-Laure Rasseneur, Laurence Dufour, Stéphane Richard, Ruddy Piquard, François Geny, Bernard Zoll, Joffrey |
| description | Introduction: Statins are associated with adverse skeletal muscle effects. Our objective was to determine if muscular adaptations following exercise training prevented deleterious effects of atorvastatin in glycolytic skeletal muscle. Methods: Twenty rats were divided into 2 groups: a control group (n = 10; Cont) and a 10 days of training group (n = 10; Training). Using the permeabilized fibers technique, we explored mitochondrial function. Results: Exercise training increased Vmax and H2O2 production without altering the free radical leak, and mRNA expression of SOD2 and Cox1 were higher in trained muscle. In the Cont group, atorvastatin exposure increased H2O2 production and decreased skeletal muscle Vmax. The decreased Vmax effect of atorvastatin was dose dependent. Interestingly, the half‐maximal inhibitory concentration (IC50) was higher in the Training group. H2O2 production increased in trained muscle after atorvastatin exposure. Conclusions: These results suggest that improvements in mitochondrial respiratory and antioxidant capacities following endurance training protected mitochondria against statin exposure. Muscle Nerve 46: 367–373, 2012 |
| doi_str_mv | 10.1002/mus.23309 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1034656930</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1034656930</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3939-86a7f69b02347d1bbda93099cc4dbf8b46bd8c4be60ca007431886d9fb075eb83</originalsourceid><addsrcrecordid>eNp1kEtTVDEQRlOUlgzgwj9g3Y1VsriQm2TyWAoFgxbIQhBYpfLolJH7wCRTyr8n4wy4ctWLPn26-0PoXYcPOozJ4bDMB4RSrLbQrMNKtGyu5Cs0wx2TLafqdhvt5PwTY9xJLt6gbUIUFoSIGbq7iGVyP6bRp2iaKTQlmTiCb_I99FBM31S566ExCZqHNBVwpXZDmobGrwhIcVrmBkKonbwy5GJKHPMeeh1Mn-Htpu6i69OTq-Oz9vxy8fn403nrqKKqldyIwJXFhDLhO2u9UfUT5RzzNkjLuPXSMQscO4OxYLSTknsVLBZzsJLuoo9rb73u1xJy0UPMDvrejFAv0x2mjM95lVZ0f426NOWcIOiHFAeTHiukV0nq-qz-m2Rl32-0SzuAfyGfo6vAhw1gsjN9SGZ0Mf_jOK1xE1a5wzX3O_bw-P-N-uL62_Pqdj0Rc4E_LxMm3WsuqJjrm68LfYOPyPfFl1t9RZ8ArtqaoA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1034656930</pqid></control><display><type>article</type><title>Mitochondria of trained skeletal muscle are protected from deleterious effects of statins</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Bouitbir, Jamal ; Daussin, Frédéric ; Charles, Anne-Laure ; Rasseneur, Laurence ; Dufour, Stéphane ; Richard, Ruddy ; Piquard, François ; Geny, Bernard ; Zoll, Joffrey</creator><creatorcontrib>Bouitbir, Jamal ; Daussin, Frédéric ; Charles, Anne-Laure ; Rasseneur, Laurence ; Dufour, Stéphane ; Richard, Ruddy ; Piquard, François ; Geny, Bernard ; Zoll, Joffrey</creatorcontrib><description>Introduction: Statins are associated with adverse skeletal muscle effects. Our objective was to determine if muscular adaptations following exercise training prevented deleterious effects of atorvastatin in glycolytic skeletal muscle. Methods: Twenty rats were divided into 2 groups: a control group (n = 10; Cont) and a 10 days of training group (n = 10; Training). Using the permeabilized fibers technique, we explored mitochondrial function. Results: Exercise training increased Vmax and H2O2 production without altering the free radical leak, and mRNA expression of SOD2 and Cox1 were higher in trained muscle. In the Cont group, atorvastatin exposure increased H2O2 production and decreased skeletal muscle Vmax. The decreased Vmax effect of atorvastatin was dose dependent. Interestingly, the half‐maximal inhibitory concentration (IC50) was higher in the Training group. H2O2 production increased in trained muscle after atorvastatin exposure. Conclusions: These results suggest that improvements in mitochondrial respiratory and antioxidant capacities following endurance training protected mitochondria against statin exposure. Muscle Nerve 46: 367–373, 2012</description><identifier>ISSN: 0148-639X</identifier><identifier>EISSN: 1097-4598</identifier><identifier>DOI: 10.1002/mus.23309</identifier><identifier>PMID: 22907227</identifier><identifier>CODEN: MUNEDE</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Atorvastatin Calcium ; Biological and medical sciences ; Electrodiagnosis. Electric activity recording ; exercise training ; Fundamental and applied biological sciences. Psychology ; glycolytic muscle ; Heptanoic Acids - adverse effects ; Heptanoic Acids - pharmacology ; Hydrogen Peroxide - metabolism ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Mitochondria, Muscle - drug effects ; Mitochondria, Muscle - metabolism ; Mitochondria, Muscle - physiology ; mitochondrial respiration ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - metabolism ; Muscle, Skeletal - physiology ; Nervous system ; oxidative stress ; Oxygen Consumption - drug effects ; Oxygen Consumption - physiology ; Physical Conditioning, Animal - physiology ; Physical Endurance - physiology ; Pyrroles - adverse effects ; Pyrroles - pharmacology ; Rats ; Rats, Wistar ; Reactive Oxygen Species - metabolism ; statins ; Striated muscle. Tendons ; Vertebrates: osteoarticular system, musculoskeletal system</subject><ispartof>Muscle & nerve, 2012-09, Vol.46 (3), p.367-373</ispartof><rights>Copyright © 2012 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3939-86a7f69b02347d1bbda93099cc4dbf8b46bd8c4be60ca007431886d9fb075eb83</citedby><cites>FETCH-LOGICAL-c3939-86a7f69b02347d1bbda93099cc4dbf8b46bd8c4be60ca007431886d9fb075eb83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmus.23309$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmus.23309$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26300124$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22907227$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bouitbir, Jamal</creatorcontrib><creatorcontrib>Daussin, Frédéric</creatorcontrib><creatorcontrib>Charles, Anne-Laure</creatorcontrib><creatorcontrib>Rasseneur, Laurence</creatorcontrib><creatorcontrib>Dufour, Stéphane</creatorcontrib><creatorcontrib>Richard, Ruddy</creatorcontrib><creatorcontrib>Piquard, François</creatorcontrib><creatorcontrib>Geny, Bernard</creatorcontrib><creatorcontrib>Zoll, Joffrey</creatorcontrib><title>Mitochondria of trained skeletal muscle are protected from deleterious effects of statins</title><title>Muscle & nerve</title><addtitle>Muscle Nerve</addtitle><description>Introduction: Statins are associated with adverse skeletal muscle effects. Our objective was to determine if muscular adaptations following exercise training prevented deleterious effects of atorvastatin in glycolytic skeletal muscle. Methods: Twenty rats were divided into 2 groups: a control group (n = 10; Cont) and a 10 days of training group (n = 10; Training). Using the permeabilized fibers technique, we explored mitochondrial function. Results: Exercise training increased Vmax and H2O2 production without altering the free radical leak, and mRNA expression of SOD2 and Cox1 were higher in trained muscle. In the Cont group, atorvastatin exposure increased H2O2 production and decreased skeletal muscle Vmax. The decreased Vmax effect of atorvastatin was dose dependent. Interestingly, the half‐maximal inhibitory concentration (IC50) was higher in the Training group. H2O2 production increased in trained muscle after atorvastatin exposure. Conclusions: These results suggest that improvements in mitochondrial respiratory and antioxidant capacities following endurance training protected mitochondria against statin exposure. Muscle Nerve 46: 367–373, 2012</description><subject>Animals</subject><subject>Atorvastatin Calcium</subject><subject>Biological and medical sciences</subject><subject>Electrodiagnosis. Electric activity recording</subject><subject>exercise training</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>glycolytic muscle</subject><subject>Heptanoic Acids - adverse effects</subject><subject>Heptanoic Acids - pharmacology</subject><subject>Hydrogen Peroxide - metabolism</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mitochondria, Muscle - drug effects</subject><subject>Mitochondria, Muscle - metabolism</subject><subject>Mitochondria, Muscle - physiology</subject><subject>mitochondrial respiration</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscle, Skeletal - physiology</subject><subject>Nervous system</subject><subject>oxidative stress</subject><subject>Oxygen Consumption - drug effects</subject><subject>Oxygen Consumption - physiology</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Physical Endurance - physiology</subject><subject>Pyrroles - adverse effects</subject><subject>Pyrroles - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>statins</subject><subject>Striated muscle. Tendons</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>0148-639X</issn><issn>1097-4598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtTVDEQRlOUlgzgwj9g3Y1VsriQm2TyWAoFgxbIQhBYpfLolJH7wCRTyr8n4wy4ctWLPn26-0PoXYcPOozJ4bDMB4RSrLbQrMNKtGyu5Cs0wx2TLafqdhvt5PwTY9xJLt6gbUIUFoSIGbq7iGVyP6bRp2iaKTQlmTiCb_I99FBM31S566ExCZqHNBVwpXZDmobGrwhIcVrmBkKonbwy5GJKHPMeeh1Mn-Htpu6i69OTq-Oz9vxy8fn403nrqKKqldyIwJXFhDLhO2u9UfUT5RzzNkjLuPXSMQscO4OxYLSTknsVLBZzsJLuoo9rb73u1xJy0UPMDvrejFAv0x2mjM95lVZ0f426NOWcIOiHFAeTHiukV0nq-qz-m2Rl32-0SzuAfyGfo6vAhw1gsjN9SGZ0Mf_jOK1xE1a5wzX3O_bw-P-N-uL62_Pqdj0Rc4E_LxMm3WsuqJjrm68LfYOPyPfFl1t9RZ8ArtqaoA</recordid><startdate>201209</startdate><enddate>201209</enddate><creator>Bouitbir, Jamal</creator><creator>Daussin, Frédéric</creator><creator>Charles, Anne-Laure</creator><creator>Rasseneur, Laurence</creator><creator>Dufour, Stéphane</creator><creator>Richard, Ruddy</creator><creator>Piquard, François</creator><creator>Geny, Bernard</creator><creator>Zoll, Joffrey</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201209</creationdate><title>Mitochondria of trained skeletal muscle are protected from deleterious effects of statins</title><author>Bouitbir, Jamal ; Daussin, Frédéric ; Charles, Anne-Laure ; Rasseneur, Laurence ; Dufour, Stéphane ; Richard, Ruddy ; Piquard, François ; Geny, Bernard ; Zoll, Joffrey</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3939-86a7f69b02347d1bbda93099cc4dbf8b46bd8c4be60ca007431886d9fb075eb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Atorvastatin Calcium</topic><topic>Biological and medical sciences</topic><topic>Electrodiagnosis. Electric activity recording</topic><topic>exercise training</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>glycolytic muscle</topic><topic>Heptanoic Acids - adverse effects</topic><topic>Heptanoic Acids - pharmacology</topic><topic>Hydrogen Peroxide - metabolism</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mitochondria, Muscle - drug effects</topic><topic>Mitochondria, Muscle - metabolism</topic><topic>Mitochondria, Muscle - physiology</topic><topic>mitochondrial respiration</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscle, Skeletal - physiology</topic><topic>Nervous system</topic><topic>oxidative stress</topic><topic>Oxygen Consumption - drug effects</topic><topic>Oxygen Consumption - physiology</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>Physical Endurance - physiology</topic><topic>Pyrroles - adverse effects</topic><topic>Pyrroles - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>statins</topic><topic>Striated muscle. Tendons</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bouitbir, Jamal</creatorcontrib><creatorcontrib>Daussin, Frédéric</creatorcontrib><creatorcontrib>Charles, Anne-Laure</creatorcontrib><creatorcontrib>Rasseneur, Laurence</creatorcontrib><creatorcontrib>Dufour, Stéphane</creatorcontrib><creatorcontrib>Richard, Ruddy</creatorcontrib><creatorcontrib>Piquard, François</creatorcontrib><creatorcontrib>Geny, Bernard</creatorcontrib><creatorcontrib>Zoll, Joffrey</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Muscle & nerve</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bouitbir, Jamal</au><au>Daussin, Frédéric</au><au>Charles, Anne-Laure</au><au>Rasseneur, Laurence</au><au>Dufour, Stéphane</au><au>Richard, Ruddy</au><au>Piquard, François</au><au>Geny, Bernard</au><au>Zoll, Joffrey</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mitochondria of trained skeletal muscle are protected from deleterious effects of statins</atitle><jtitle>Muscle & nerve</jtitle><addtitle>Muscle Nerve</addtitle><date>2012-09</date><risdate>2012</risdate><volume>46</volume><issue>3</issue><spage>367</spage><epage>373</epage><pages>367-373</pages><issn>0148-639X</issn><eissn>1097-4598</eissn><coden>MUNEDE</coden><abstract>Introduction: Statins are associated with adverse skeletal muscle effects. Our objective was to determine if muscular adaptations following exercise training prevented deleterious effects of atorvastatin in glycolytic skeletal muscle. Methods: Twenty rats were divided into 2 groups: a control group (n = 10; Cont) and a 10 days of training group (n = 10; Training). Using the permeabilized fibers technique, we explored mitochondrial function. Results: Exercise training increased Vmax and H2O2 production without altering the free radical leak, and mRNA expression of SOD2 and Cox1 were higher in trained muscle. In the Cont group, atorvastatin exposure increased H2O2 production and decreased skeletal muscle Vmax. The decreased Vmax effect of atorvastatin was dose dependent. Interestingly, the half‐maximal inhibitory concentration (IC50) was higher in the Training group. H2O2 production increased in trained muscle after atorvastatin exposure. Conclusions: These results suggest that improvements in mitochondrial respiratory and antioxidant capacities following endurance training protected mitochondria against statin exposure. Muscle Nerve 46: 367–373, 2012</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>22907227</pmid><doi>10.1002/mus.23309</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0148-639X |
| ispartof | Muscle & nerve, 2012-09, Vol.46 (3), p.367-373 |
| issn | 0148-639X 1097-4598 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1034656930 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Atorvastatin Calcium Biological and medical sciences Electrodiagnosis. Electric activity recording exercise training Fundamental and applied biological sciences. Psychology glycolytic muscle Heptanoic Acids - adverse effects Heptanoic Acids - pharmacology Hydrogen Peroxide - metabolism Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Mitochondria, Muscle - drug effects Mitochondria, Muscle - metabolism Mitochondria, Muscle - physiology mitochondrial respiration Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscle, Skeletal - physiology Nervous system oxidative stress Oxygen Consumption - drug effects Oxygen Consumption - physiology Physical Conditioning, Animal - physiology Physical Endurance - physiology Pyrroles - adverse effects Pyrroles - pharmacology Rats Rats, Wistar Reactive Oxygen Species - metabolism statins Striated muscle. Tendons Vertebrates: osteoarticular system, musculoskeletal system |
| title | Mitochondria of trained skeletal muscle are protected from deleterious effects of statins |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T01%3A53%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mitochondria%20of%20trained%20skeletal%20muscle%20are%20protected%20from%20deleterious%20effects%20of%20statins&rft.jtitle=Muscle%20&%20nerve&rft.au=Bouitbir,%20Jamal&rft.date=2012-09&rft.volume=46&rft.issue=3&rft.spage=367&rft.epage=373&rft.pages=367-373&rft.issn=0148-639X&rft.eissn=1097-4598&rft.coden=MUNEDE&rft_id=info:doi/10.1002/mus.23309&rft_dat=%3Cproquest_cross%3E1034656930%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1034656930&rft_id=info:pmid/22907227&rfr_iscdi=true |