Hepatoprotective and anti-inflammatory effects of silibinin on experimental preeclampsia induced by l-NAME in rats

Inhibition of nitric oxide synthase with N-omega-nitro-l-arginine methyl ester (l-NAME) has been employed as an experimental model of human preeclampsia. This study determined the protective effect of silibinin, a flavonoid with anti-inflammatory and hepatoprotective properties on the deleterious ef...

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Veröffentlicht in:	Life sciences (1973) 2012-09, Vol.91 (5-6), p.159-165
Hauptverfasser:	de Souza, Camila Oliveira, Peraçoli, Maria Terezinha Serrão, Weel, Ingrid Cristina, Bannwart, Camila Ferreira, Romão, Mariana, Nakaira-Takahagi, Érika, de Medeiros, Leonardo Teixeira Lopes, da Silva, Márcia Guimarães, Peraçoli, José Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-inflammatory activity Anti-Inflammatory Agents - pharmacology blood platelet count Blood Pressure - drug effects Cytokines Disease Models, Animal drinking water enzyme immunoassays Enzyme-Linked Immunosorbent Assay Female flavonoids hepatoprotective effect histopathology humans Immunologic Factors - pharmacology immunomodulation Inflammation - drug therapy Inflammation - physiopathology interferon-gamma interleukin-10 interleukin-1beta interleukin-6 l-NAME liver Liver - drug effects Liver - pathology muscles NG-Nitroarginine Methyl Ester nitric oxide synthase pre-eclampsia Pre-Eclampsia - drug therapy Preeclampsia Pregnancy Pregnant rats Protective Agents - pharmacology proteinuria Rats Rats, Wistar Silibinin Silymarin - pharmacology systolic blood pressure tumor necrosis factor-alpha
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