MR prediction of liver fibrosis using a liver-specific contrast agent: Superparamagnetic iron oxide versus Gd-EOB-DTPA
Purpose: To examine whether the uptake of a liver‐specific contrast agent in the liver parenchyma was correlated with the degree of liver fibrosis. Materials and Methods: This retrospective study included 54 and 63 patients who underwent superparamagnetic iron oxide (SPIO)‐ and gadolinium ethoxybenz...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2012-09, Vol.36 (3), p.664-671 |
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| creator | Nishie, Akihiro Asayama, Yoshiki Ishigami, Kousei Tajima, Tsuyoshi Kakihara, Daisuke Nakayama, Tomohiro Takayama, Yukihisa Okamoto, Daisuke Taketomi, Akinobu Shirabe, Ken Fujita, Nobuhiro Obara, Makoto Yoshimitsu, Kengo Honda, Hiroshi |
| description | Purpose:
To examine whether the uptake of a liver‐specific contrast agent in the liver parenchyma was correlated with the degree of liver fibrosis.
Materials and Methods:
This retrospective study included 54 and 63 patients who underwent superparamagnetic iron oxide (SPIO)‐ and gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd‐EOB‐DTPA)‐enhanced MRI before liver surgery, respectively. For each patient, we calculated ΔR2* and ΔR2, which represent differences in R2* and R2 values of the liver parenchyma before and after administration of SPIO; and the increase rate of liver‐to‐spleen signal intensity ratio (LSR) on the hepatobiliary phase compared with the precontrast image. The correlation of each MR parameter with the degree of liver fibrosis (F0 to F4) was assessed using Spearman's rank correlation test.
Results:
The increase rate of LSR was best correlated with the degree of liver fibrosis and significantly decreased as the liver fibrosis progressed (rho = −0.641; P < 0.0001). It showed sensitivity of 76.9% and specificity of 83.3% in differentiating F3 or greater fibrosis when 1.126 or less was set up as a cut‐off value. No significant correlation was obtained between ΔR2* or ΔR2 and the degree of liver fibrosis.
Conclusion:
The uptake of Gd‐EOB‐DTPA in the liver parenchyma decreased as the liver fibrosis progressed. J. Magn. Reson. Imaging 2012;36:664–671. © 2012 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jmri.23691 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1034516271</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1034516271</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4691-f9babe86d0b3e8faa736657476b8eba7fafe8f37cc16b5acaca0105239a0d6573</originalsourceid><addsrcrecordid>eNp9kEtvFDEQhC0EIiFw4QcgHxGSgx9re4Zbsgm7QVmCliCOlsfTXjnMC3smJP8eL5PkiPrQrdZXJVUh9JbRY0Yp_3jTxnDMhSrZM3TIJOeEy0I9zzeVgrCC6gP0KqUbSmlZLuRLdMC5FFxScYhuN1s8RKiDG0Pf4d7jJtxCxD5UsU8h4SmFboft_CZpABd8cNj13RhtGrHdQTd-wt-nAeJgo23troMxEyHu_e5CDTgr05TwqibnV6fk7PrbyWv0wtsmwZuHfYR-fD6_Xq7J5dXqYnlySdwixyG-rGwFhappJaDw1mqhlNQLraoCKqu99fkttHNMVdK6PDSH5qK0tM6gOELvZ98h9r8nSKNpQ3LQNLaDfkqGUbGQTHHNMvphRl0OniJ4M8TQ2nifIbPv2ex7Nv96zvC7B9-paqF-Qh-LzQCbgT-hgfv_WJkvm-3FoymZNSGNcPeksfGXUVpoaX5-XZn19my5EWxp1uIvxkaY8Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1034516271</pqid></control><display><type>article</type><title>MR prediction of liver fibrosis using a liver-specific contrast agent: Superparamagnetic iron oxide versus Gd-EOB-DTPA</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Wiley Online Library (Open Access Collection)</source><creator>Nishie, Akihiro ; Asayama, Yoshiki ; Ishigami, Kousei ; Tajima, Tsuyoshi ; Kakihara, Daisuke ; Nakayama, Tomohiro ; Takayama, Yukihisa ; Okamoto, Daisuke ; Taketomi, Akinobu ; Shirabe, Ken ; Fujita, Nobuhiro ; Obara, Makoto ; Yoshimitsu, Kengo ; Honda, Hiroshi</creator><creatorcontrib>Nishie, Akihiro ; Asayama, Yoshiki ; Ishigami, Kousei ; Tajima, Tsuyoshi ; Kakihara, Daisuke ; Nakayama, Tomohiro ; Takayama, Yukihisa ; Okamoto, Daisuke ; Taketomi, Akinobu ; Shirabe, Ken ; Fujita, Nobuhiro ; Obara, Makoto ; Yoshimitsu, Kengo ; Honda, Hiroshi</creatorcontrib><description>Purpose:
To examine whether the uptake of a liver‐specific contrast agent in the liver parenchyma was correlated with the degree of liver fibrosis.
Materials and Methods:
This retrospective study included 54 and 63 patients who underwent superparamagnetic iron oxide (SPIO)‐ and gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd‐EOB‐DTPA)‐enhanced MRI before liver surgery, respectively. For each patient, we calculated ΔR2* and ΔR2, which represent differences in R2* and R2 values of the liver parenchyma before and after administration of SPIO; and the increase rate of liver‐to‐spleen signal intensity ratio (LSR) on the hepatobiliary phase compared with the precontrast image. The correlation of each MR parameter with the degree of liver fibrosis (F0 to F4) was assessed using Spearman's rank correlation test.
Results:
The increase rate of LSR was best correlated with the degree of liver fibrosis and significantly decreased as the liver fibrosis progressed (rho = −0.641; P < 0.0001). It showed sensitivity of 76.9% and specificity of 83.3% in differentiating F3 or greater fibrosis when 1.126 or less was set up as a cut‐off value. No significant correlation was obtained between ΔR2* or ΔR2 and the degree of liver fibrosis.
Conclusion:
The uptake of Gd‐EOB‐DTPA in the liver parenchyma decreased as the liver fibrosis progressed. J. Magn. Reson. Imaging 2012;36:664–671. © 2012 Wiley Periodicals, Inc.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.23691</identifier><identifier>PMID: 22532503</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Contrast Media ; Dextrans ; Female ; Gadolinium DTPA ; Gd-EOB-DTPA ; Humans ; Image Enhancement - methods ; liver cirrhosis ; Liver Cirrhosis - pathology ; Magnetic Resonance Imaging - methods ; Magnetite Nanoparticles ; Middle Aged ; MRI ; Reproducibility of Results ; Sensitivity and Specificity ; superparamagnetic iron oxide</subject><ispartof>Journal of magnetic resonance imaging, 2012-09, Vol.36 (3), p.664-671</ispartof><rights>Copyright © 2012 Wiley‐Liss, Inc.</rights><rights>Copyright © 2012 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4691-f9babe86d0b3e8faa736657476b8eba7fafe8f37cc16b5acaca0105239a0d6573</citedby><cites>FETCH-LOGICAL-c4691-f9babe86d0b3e8faa736657476b8eba7fafe8f37cc16b5acaca0105239a0d6573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.23691$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.23691$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,1434,27929,27930,45579,45580,46414,46838</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22532503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nishie, Akihiro</creatorcontrib><creatorcontrib>Asayama, Yoshiki</creatorcontrib><creatorcontrib>Ishigami, Kousei</creatorcontrib><creatorcontrib>Tajima, Tsuyoshi</creatorcontrib><creatorcontrib>Kakihara, Daisuke</creatorcontrib><creatorcontrib>Nakayama, Tomohiro</creatorcontrib><creatorcontrib>Takayama, Yukihisa</creatorcontrib><creatorcontrib>Okamoto, Daisuke</creatorcontrib><creatorcontrib>Taketomi, Akinobu</creatorcontrib><creatorcontrib>Shirabe, Ken</creatorcontrib><creatorcontrib>Fujita, Nobuhiro</creatorcontrib><creatorcontrib>Obara, Makoto</creatorcontrib><creatorcontrib>Yoshimitsu, Kengo</creatorcontrib><creatorcontrib>Honda, Hiroshi</creatorcontrib><title>MR prediction of liver fibrosis using a liver-specific contrast agent: Superparamagnetic iron oxide versus Gd-EOB-DTPA</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose:
To examine whether the uptake of a liver‐specific contrast agent in the liver parenchyma was correlated with the degree of liver fibrosis.
Materials and Methods:
This retrospective study included 54 and 63 patients who underwent superparamagnetic iron oxide (SPIO)‐ and gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd‐EOB‐DTPA)‐enhanced MRI before liver surgery, respectively. For each patient, we calculated ΔR2* and ΔR2, which represent differences in R2* and R2 values of the liver parenchyma before and after administration of SPIO; and the increase rate of liver‐to‐spleen signal intensity ratio (LSR) on the hepatobiliary phase compared with the precontrast image. The correlation of each MR parameter with the degree of liver fibrosis (F0 to F4) was assessed using Spearman's rank correlation test.
Results:
The increase rate of LSR was best correlated with the degree of liver fibrosis and significantly decreased as the liver fibrosis progressed (rho = −0.641; P < 0.0001). It showed sensitivity of 76.9% and specificity of 83.3% in differentiating F3 or greater fibrosis when 1.126 or less was set up as a cut‐off value. No significant correlation was obtained between ΔR2* or ΔR2 and the degree of liver fibrosis.
Conclusion:
The uptake of Gd‐EOB‐DTPA in the liver parenchyma decreased as the liver fibrosis progressed. J. Magn. Reson. Imaging 2012;36:664–671. © 2012 Wiley Periodicals, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Contrast Media</subject><subject>Dextrans</subject><subject>Female</subject><subject>Gadolinium DTPA</subject><subject>Gd-EOB-DTPA</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>liver cirrhosis</subject><subject>Liver Cirrhosis - pathology</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetite Nanoparticles</subject><subject>Middle Aged</subject><subject>MRI</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>superparamagnetic iron oxide</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtvFDEQhC0EIiFw4QcgHxGSgx9re4Zbsgm7QVmCliCOlsfTXjnMC3smJP8eL5PkiPrQrdZXJVUh9JbRY0Yp_3jTxnDMhSrZM3TIJOeEy0I9zzeVgrCC6gP0KqUbSmlZLuRLdMC5FFxScYhuN1s8RKiDG0Pf4d7jJtxCxD5UsU8h4SmFboft_CZpABd8cNj13RhtGrHdQTd-wt-nAeJgo23troMxEyHu_e5CDTgr05TwqibnV6fk7PrbyWv0wtsmwZuHfYR-fD6_Xq7J5dXqYnlySdwixyG-rGwFhappJaDw1mqhlNQLraoCKqu99fkttHNMVdK6PDSH5qK0tM6gOELvZ98h9r8nSKNpQ3LQNLaDfkqGUbGQTHHNMvphRl0OniJ4M8TQ2nifIbPv2ex7Nv96zvC7B9-paqF-Qh-LzQCbgT-hgfv_WJkvm-3FoymZNSGNcPeksfGXUVpoaX5-XZn19my5EWxp1uIvxkaY8Q</recordid><startdate>201209</startdate><enddate>201209</enddate><creator>Nishie, Akihiro</creator><creator>Asayama, Yoshiki</creator><creator>Ishigami, Kousei</creator><creator>Tajima, Tsuyoshi</creator><creator>Kakihara, Daisuke</creator><creator>Nakayama, Tomohiro</creator><creator>Takayama, Yukihisa</creator><creator>Okamoto, Daisuke</creator><creator>Taketomi, Akinobu</creator><creator>Shirabe, Ken</creator><creator>Fujita, Nobuhiro</creator><creator>Obara, Makoto</creator><creator>Yoshimitsu, Kengo</creator><creator>Honda, Hiroshi</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201209</creationdate><title>MR prediction of liver fibrosis using a liver-specific contrast agent: Superparamagnetic iron oxide versus Gd-EOB-DTPA</title><author>Nishie, Akihiro ; Asayama, Yoshiki ; Ishigami, Kousei ; Tajima, Tsuyoshi ; Kakihara, Daisuke ; Nakayama, Tomohiro ; Takayama, Yukihisa ; Okamoto, Daisuke ; Taketomi, Akinobu ; Shirabe, Ken ; Fujita, Nobuhiro ; Obara, Makoto ; Yoshimitsu, Kengo ; Honda, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4691-f9babe86d0b3e8faa736657476b8eba7fafe8f37cc16b5acaca0105239a0d6573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Contrast Media</topic><topic>Dextrans</topic><topic>Female</topic><topic>Gadolinium DTPA</topic><topic>Gd-EOB-DTPA</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>liver cirrhosis</topic><topic>Liver Cirrhosis - pathology</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetite Nanoparticles</topic><topic>Middle Aged</topic><topic>MRI</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>superparamagnetic iron oxide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nishie, Akihiro</creatorcontrib><creatorcontrib>Asayama, Yoshiki</creatorcontrib><creatorcontrib>Ishigami, Kousei</creatorcontrib><creatorcontrib>Tajima, Tsuyoshi</creatorcontrib><creatorcontrib>Kakihara, Daisuke</creatorcontrib><creatorcontrib>Nakayama, Tomohiro</creatorcontrib><creatorcontrib>Takayama, Yukihisa</creatorcontrib><creatorcontrib>Okamoto, Daisuke</creatorcontrib><creatorcontrib>Taketomi, Akinobu</creatorcontrib><creatorcontrib>Shirabe, Ken</creatorcontrib><creatorcontrib>Fujita, Nobuhiro</creatorcontrib><creatorcontrib>Obara, Makoto</creatorcontrib><creatorcontrib>Yoshimitsu, Kengo</creatorcontrib><creatorcontrib>Honda, Hiroshi</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nishie, Akihiro</au><au>Asayama, Yoshiki</au><au>Ishigami, Kousei</au><au>Tajima, Tsuyoshi</au><au>Kakihara, Daisuke</au><au>Nakayama, Tomohiro</au><au>Takayama, Yukihisa</au><au>Okamoto, Daisuke</au><au>Taketomi, Akinobu</au><au>Shirabe, Ken</au><au>Fujita, Nobuhiro</au><au>Obara, Makoto</au><au>Yoshimitsu, Kengo</au><au>Honda, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MR prediction of liver fibrosis using a liver-specific contrast agent: Superparamagnetic iron oxide versus Gd-EOB-DTPA</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2012-09</date><risdate>2012</risdate><volume>36</volume><issue>3</issue><spage>664</spage><epage>671</epage><pages>664-671</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose:
To examine whether the uptake of a liver‐specific contrast agent in the liver parenchyma was correlated with the degree of liver fibrosis.
Materials and Methods:
This retrospective study included 54 and 63 patients who underwent superparamagnetic iron oxide (SPIO)‐ and gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd‐EOB‐DTPA)‐enhanced MRI before liver surgery, respectively. For each patient, we calculated ΔR2* and ΔR2, which represent differences in R2* and R2 values of the liver parenchyma before and after administration of SPIO; and the increase rate of liver‐to‐spleen signal intensity ratio (LSR) on the hepatobiliary phase compared with the precontrast image. The correlation of each MR parameter with the degree of liver fibrosis (F0 to F4) was assessed using Spearman's rank correlation test.
Results:
The increase rate of LSR was best correlated with the degree of liver fibrosis and significantly decreased as the liver fibrosis progressed (rho = −0.641; P < 0.0001). It showed sensitivity of 76.9% and specificity of 83.3% in differentiating F3 or greater fibrosis when 1.126 or less was set up as a cut‐off value. No significant correlation was obtained between ΔR2* or ΔR2 and the degree of liver fibrosis.
Conclusion:
The uptake of Gd‐EOB‐DTPA in the liver parenchyma decreased as the liver fibrosis progressed. J. Magn. Reson. Imaging 2012;36:664–671. © 2012 Wiley Periodicals, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>22532503</pmid><doi>10.1002/jmri.23691</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Contrast Media Dextrans Female Gadolinium DTPA Gd-EOB-DTPA Humans Image Enhancement - methods liver cirrhosis Liver Cirrhosis - pathology Magnetic Resonance Imaging - methods Magnetite Nanoparticles Middle Aged MRI Reproducibility of Results Sensitivity and Specificity superparamagnetic iron oxide |
| title | MR prediction of liver fibrosis using a liver-specific contrast agent: Superparamagnetic iron oxide versus Gd-EOB-DTPA |
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