Supplementation with branched-chain amino acids attenuates hepatic apoptosis in rats with chronic liver disease

Abstract Branched-chain amino acids (BCAA) can function as pharmacologic nutrients for patients with decompensated cirrhosis. However, the effects of BCAA at the early stage of chronic liver disease are not clear. We hypothesized that early BCAA supplementation would attenuate the progression of chr...

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Veröffentlicht in:	Nutrition research (New York, N.Y.) N.Y.), 2012-07, Vol.32 (7), p.522-529
Hauptverfasser:	Kuwahata, Masashi, Kubota, Hiroyo, Kanouchi, Hiroaki, Ito, Shunsuke, Ogawa, Aki, Kobayashi, Yukiko, Kido, Yasuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	alanine transaminase amino acids Amino Acids, Branched-Chain - administration & dosage Amino Acids, Branched-Chain - blood Animals Apoptosis Apoptosis - drug effects bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Biological and medical sciences Blotting, Western Branched-chain amino acids Carbon tetrachloride Carbon Tetrachloride - toxicity casein Caseins - administration & dosage Chronic Disease chronic diseases connective tissues cytochrome c Dietary Supplements Feeding. Feeding behavior Fibrosis food intake Fundamental and applied biological sciences. Psychology Gastroenterology and Hepatology growth factors In Situ Nick-End Labeling liver Liver - drug effects Liver - metabolism liver cirrhosis Liver Cirrhosis, Experimental - chemically induced Liver Cirrhosis, Experimental - drug therapy Liver Cirrhosis, Experimental - pathology Liver diseases Male messenger RNA nutrients Rats Rats, Sprague-Dawley Sequence Analysis, RNA Vertebrates: anatomy and physiology, studies on body, several organs or systems
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