The A to G polymorphism at -1082 of the interleukin-10 gene is rare in the Han Chinese population
Interleukin-10 (IL-10) is a multifunctional anti-inflammatory cytokine involved in various physiological and pathophysiological processes including cardiovascular disease. It has been reported that 50-75% of the variation in IL-10 production is genetically controlled. In the present study, the IL-10...
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| Veröffentlicht in: | Molecular medicine reports 2012-10, Vol.6 (4), p.894-896 |
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| creator | GUO, JING HE, YONG-HUI CHEN, FENG JIANG, MIN-HUI GAO, SHU-PING SU, YA-MING SHI, GUI-LIANG DENG, XIN-TAO ZHU, JIAN-HUA PAN, MIN |
| description | Interleukin-10 (IL-10) is a multifunctional anti-inflammatory cytokine involved in various physiological and pathophysiological processes including cardiovascular disease. It has been reported that 50-75% of the variation in IL-10 production is genetically controlled. In the present study, the IL-10 -1082A/G (rs1800896) polymorphism was detected in 174 coronary artery disease (CAD) patients confirmed by selective coronary angiography and 176 age and gender-matched controls from the Jiangsu area (East China). The majority of the subjects (93.14%) carried the AA wild-type genotype, whereas only 0.29% carried the GG genotype. Our results suggest that IL-10 -1082A/G is rare and unlikely to be a significant contributory to disease susceptibility in the Han Chinese population. |
| doi_str_mv | 10.3892/mmr.2012.995 |
| format | Article |
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It has been reported that 50-75% of the variation in IL-10 production is genetically controlled. In the present study, the IL-10 -1082A/G (rs1800896) polymorphism was detected in 174 coronary artery disease (CAD) patients confirmed by selective coronary angiography and 176 age and gender-matched controls from the Jiangsu area (East China). The majority of the subjects (93.14%) carried the AA wild-type genotype, whereas only 0.29% carried the GG genotype. Our results suggest that IL-10 -1082A/G is rare and unlikely to be a significant contributory to disease susceptibility in the Han Chinese population.</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2012.995</identifier><identifier>PMID: 22825546</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Alleles ; Angiography ; Asian Continental Ancestry Group - genetics ; Atherosclerosis ; Cardiovascular disease ; China ; Chinese ; Coronary Angiography ; Coronary artery ; Coronary Artery Disease - genetics ; Coronary Artery Disease - metabolism ; Coronary Artery Disease - pathology ; Coronary vessels ; Cytokines ; Cytotoxicity ; Deoxyribonucleic acid ; Disease Susceptibility ; DNA ; Ethnicity ; Gene Frequency ; Gene polymorphism ; genetic polymorphism ; Genotype ; Heart diseases ; Humans ; Inflammation ; Interleukin 10 ; Interleukin-10 - genetics ; Medical imaging ; Polymorphism ; Polymorphism, Single Nucleotide ; Population ; Promoter Regions, Genetic ; Studies</subject><ispartof>Molecular medicine reports, 2012-10, Vol.6 (4), p.894-896</ispartof><rights>Copyright © 2012, Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-b4ebf4d51eb00b3f378f9d41aaa77e09928cb7e4e3e8990bb04b2c29792b0dd73</citedby><cites>FETCH-LOGICAL-c389t-b4ebf4d51eb00b3f378f9d41aaa77e09928cb7e4e3e8990bb04b2c29792b0dd73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,5556,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22825546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GUO, JING</creatorcontrib><creatorcontrib>HE, YONG-HUI</creatorcontrib><creatorcontrib>CHEN, FENG</creatorcontrib><creatorcontrib>JIANG, MIN-HUI</creatorcontrib><creatorcontrib>GAO, SHU-PING</creatorcontrib><creatorcontrib>SU, YA-MING</creatorcontrib><creatorcontrib>SHI, GUI-LIANG</creatorcontrib><creatorcontrib>DENG, XIN-TAO</creatorcontrib><creatorcontrib>ZHU, JIAN-HUA</creatorcontrib><creatorcontrib>PAN, MIN</creatorcontrib><title>The A to G polymorphism at -1082 of the interleukin-10 gene is rare in the Han Chinese population</title><title>Molecular medicine reports</title><addtitle>Mol Med Rep</addtitle><description>Interleukin-10 (IL-10) is a multifunctional anti-inflammatory cytokine involved in various physiological and pathophysiological processes including cardiovascular disease. It has been reported that 50-75% of the variation in IL-10 production is genetically controlled. In the present study, the IL-10 -1082A/G (rs1800896) polymorphism was detected in 174 coronary artery disease (CAD) patients confirmed by selective coronary angiography and 176 age and gender-matched controls from the Jiangsu area (East China). The majority of the subjects (93.14%) carried the AA wild-type genotype, whereas only 0.29% carried the GG genotype. Our results suggest that IL-10 -1082A/G is rare and unlikely to be a significant contributory to disease susceptibility in the Han Chinese population.</description><subject>Alleles</subject><subject>Angiography</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Atherosclerosis</subject><subject>Cardiovascular disease</subject><subject>China</subject><subject>Chinese</subject><subject>Coronary Angiography</subject><subject>Coronary artery</subject><subject>Coronary Artery Disease - genetics</subject><subject>Coronary Artery Disease - metabolism</subject><subject>Coronary Artery Disease - pathology</subject><subject>Coronary vessels</subject><subject>Cytokines</subject><subject>Cytotoxicity</subject><subject>Deoxyribonucleic acid</subject><subject>Disease Susceptibility</subject><subject>DNA</subject><subject>Ethnicity</subject><subject>Gene Frequency</subject><subject>Gene polymorphism</subject><subject>genetic polymorphism</subject><subject>Genotype</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Interleukin 10</subject><subject>Interleukin-10 - genetics</subject><subject>Medical imaging</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population</subject><subject>Promoter Regions, Genetic</subject><subject>Studies</subject><issn>1791-2997</issn><issn>1791-3004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpd0Dlv3DAQBWAiiOFj7S51QCBFXESb4aFjSmPhI4ABN5taIKVRVo5EKqRU-N-H6127cEGQGH54IB9jXwSsVYXy5ziGtQQh14j5J3YuShSZAtCfj2eJWJ6xixifAYpc5njKzqSsZJ7r4pyZ7Y74DZ89v-eTH15GH6ZdH0duZp4JqCT3HZ-T6d1MYaDlb-_SnP8hl2aRBxP2d6_kwTi-2fWOIqWsaRnM3Ht3yU46M0S6Ou4r9vvudrt5yB6f7n9tbh6zJn1jzqwm2-k2F2QBrOpUWXXYamGMKUsCRFk1tiRNiipEsBa0lY3EEqWFti3Vil0fcqfg_y0U53rsY0PDYBz5JdYClJZpYZHotw_02S_BpdfVApXUBchqr34cVBN8jIG6egr9aMJLiqr31dep-npffZ2qT_zrMXSxI7Xv-K3rBL4fQJyMa_vWx3eTgjIoMtAZVKjVf6ZhicA</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>GUO, JING</creator><creator>HE, YONG-HUI</creator><creator>CHEN, FENG</creator><creator>JIANG, MIN-HUI</creator><creator>GAO, SHU-PING</creator><creator>SU, YA-MING</creator><creator>SHI, GUI-LIANG</creator><creator>DENG, XIN-TAO</creator><creator>ZHU, JIAN-HUA</creator><creator>PAN, MIN</creator><general>D.A. 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genetics</topic><topic>Atherosclerosis</topic><topic>Cardiovascular disease</topic><topic>China</topic><topic>Chinese</topic><topic>Coronary Angiography</topic><topic>Coronary artery</topic><topic>Coronary Artery Disease - genetics</topic><topic>Coronary Artery Disease - metabolism</topic><topic>Coronary Artery Disease - pathology</topic><topic>Coronary vessels</topic><topic>Cytokines</topic><topic>Cytotoxicity</topic><topic>Deoxyribonucleic acid</topic><topic>Disease Susceptibility</topic><topic>DNA</topic><topic>Ethnicity</topic><topic>Gene Frequency</topic><topic>Gene polymorphism</topic><topic>genetic polymorphism</topic><topic>Genotype</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Interleukin 10</topic><topic>Interleukin-10 - genetics</topic><topic>Medical imaging</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population</topic><topic>Promoter Regions, Genetic</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GUO, JING</creatorcontrib><creatorcontrib>HE, YONG-HUI</creatorcontrib><creatorcontrib>CHEN, FENG</creatorcontrib><creatorcontrib>JIANG, MIN-HUI</creatorcontrib><creatorcontrib>GAO, SHU-PING</creatorcontrib><creatorcontrib>SU, YA-MING</creatorcontrib><creatorcontrib>SHI, GUI-LIANG</creatorcontrib><creatorcontrib>DENG, XIN-TAO</creatorcontrib><creatorcontrib>ZHU, JIAN-HUA</creatorcontrib><creatorcontrib>PAN, MIN</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular medicine reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GUO, JING</au><au>HE, YONG-HUI</au><au>CHEN, FENG</au><au>JIANG, MIN-HUI</au><au>GAO, SHU-PING</au><au>SU, YA-MING</au><au>SHI, GUI-LIANG</au><au>DENG, XIN-TAO</au><au>ZHU, JIAN-HUA</au><au>PAN, MIN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The A to G polymorphism at -1082 of the interleukin-10 gene is rare in the Han Chinese population</atitle><jtitle>Molecular medicine reports</jtitle><addtitle>Mol Med Rep</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>6</volume><issue>4</issue><spage>894</spage><epage>896</epage><pages>894-896</pages><issn>1791-2997</issn><eissn>1791-3004</eissn><abstract>Interleukin-10 (IL-10) is a multifunctional anti-inflammatory cytokine involved in various physiological and pathophysiological processes including cardiovascular disease. It has been reported that 50-75% of the variation in IL-10 production is genetically controlled. In the present study, the IL-10 -1082A/G (rs1800896) polymorphism was detected in 174 coronary artery disease (CAD) patients confirmed by selective coronary angiography and 176 age and gender-matched controls from the Jiangsu area (East China). The majority of the subjects (93.14%) carried the AA wild-type genotype, whereas only 0.29% carried the GG genotype. Our results suggest that IL-10 -1082A/G is rare and unlikely to be a significant contributory to disease susceptibility in the Han Chinese population.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>22825546</pmid><doi>10.3892/mmr.2012.995</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | Spandidos Publications Journals; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Alleles Angiography Asian Continental Ancestry Group - genetics Atherosclerosis Cardiovascular disease China Chinese Coronary Angiography Coronary artery Coronary Artery Disease - genetics Coronary Artery Disease - metabolism Coronary Artery Disease - pathology Coronary vessels Cytokines Cytotoxicity Deoxyribonucleic acid Disease Susceptibility DNA Ethnicity Gene Frequency Gene polymorphism genetic polymorphism Genotype Heart diseases Humans Inflammation Interleukin 10 Interleukin-10 - genetics Medical imaging Polymorphism Polymorphism, Single Nucleotide Population Promoter Regions, Genetic Studies |
| title | The A to G polymorphism at -1082 of the interleukin-10 gene is rare in the Han Chinese population |
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