Role of heat shock protein 27 in gemcitabine-resistant human pancreatic cancer: Comparative proteomic analyses

The most notable obstacle hindering the effective treatment of human pancreatic cancer is intrinsic chemoresistance. In order to identify the candidate protein(s) responsible for the intrinsic chemoresistance, the protein expression profiling of human pancreatic adenocarcinoma cell line Capan-1 and...

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Veröffentlicht in:	Molecular medicine reports 2012-10, Vol.6 (4), p.767-773
Hauptverfasser:	LIU, QING-HUA, ZHAO, CHEN-YAN, ZHANG, JING, CHEN, YING, GAO, LI, NI, CAN-YONG, ZHU, MING-HUA
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Antimetabolites, Antineoplastic - pharmacology Cancer therapies Cell Line, Tumor Cell Survival - drug effects Chemoresistance Chemotherapy Chromatography, High Pressure Liquid Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacology Down-Regulation - drug effects Drug development Drug resistance Drug Resistance, Neoplasm - drug effects Electrophoresis, Gel, Two-Dimensional Female Gemcitabine heat shock protein 27 Heat shock proteins HSP27 Heat-Shock Proteins - metabolism Hsp27 protein Humans intrinsic chemoresistance Liquid chromatography Male Mass Spectrometry Mass spectroscopy Medical prognosis Metabolism Middle Aged Pancreatic cancer Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Proteome - drug effects Proteome - metabolism proteomics Signal transduction Substance abuse treatment Western blotting
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