Increased hepatic fibrosis and JNK2-dependent liver injury in mice exhibiting hepatocyte-specific deletion of cFLIP

Chronic liver disease promotes hepatocellular injury involving apoptosis and triggers compensatory regeneration that leads to the activation of quiescent stellate cells in the liver. The deposition of extracellular matrix from activated myofibroblasts promotes hepatic fibrosis and the progression to...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2012-08, Vol.303 (4), p.G498-G506
Hauptverfasser:	Schattenberg, Jörn M, Nagel, Michael, Kim, Yong Ook, Kohl, Tobias, Wörns, Marcus A, Zimmermann, Tim, Schad, Arno, Longerich, Thomas, Schuppan, Detlef, He, You-Wen, Galle, Peter R, Schuchmann, Marcus
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Carbon Tetrachloride CASP8 and FADD-Like Apoptosis Regulating Protein - deficiency CASP8 and FADD-Like Apoptosis Regulating Protein - genetics Caspase 3 - metabolism Caspase 9 - metabolism Cells Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - genetics Chemical and Drug Induced Liver Injury - pathology Disease Models, Animal Disease Progression Enzyme Activation Extracellular Signal-Regulated MAP Kinases - metabolism Genotype Hepatocytes - enzymology Hepatocytes - pathology Liver - enzymology Liver - pathology Liver Cirrhosis - enzymology Liver Cirrhosis - etiology Liver Cirrhosis - genetics Liver Cirrhosis - pathology Liver diseases Male Mice Mice, Knockout Mitogen-Activated Protein Kinase 9 - deficiency Mitogen-Activated Protein Kinase 9 - genetics Mitogen-Activated Protein Kinase 9 - metabolism Phenotype Phosphorylation Proteins Rodents Signal Transduction Thioacetamide Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!