Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma

BACKGROUND: The aim of this study was to evaluate the expression of epidermal growth factor receptor (EGFR) and insulinlike growth factor 1 receptor (IGF‐1R) proteins and IGF‐1R gene copy numbers in pancreatic ductal adenocarcinoma in relation to patients' characteristics and prognosis. METHODS...

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Veröffentlicht in:	Cancer 2012-07, Vol.118 (14), p.3484-3493
Hauptverfasser:	Valsecchi, Matias E., McDonald, Mary, Brody, Jonathan R., Hyslop, Terry, Freydin, Boris, Yeo, Charles J., Solomides, Charalambos, Peiper, Stephen C., Witkiewicz, Agnieszka K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences biomarkers Biomarkers, Tumor - metabolism Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - mortality EGFR Female Gastroenterology. Liver. Pancreas. Abdomen Gene Dosage Gene Expression Humans IGF‐1R Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged pancreatic cancer Pancreatic Neoplasms - genetics Pancreatic Neoplasms - mortality Prognosis prognostic factors Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Receptor, IGF Type 1 - genetics Receptor, IGF Type 1 - metabolism Tumors
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