Ultraviolet B-induced LGI3 secretion protects human keratinocytes

Leucine‐rich glioma inactivated 3 (LGI3) is known to be expressed mainly in the brain. However, the expression and physiological roles of LGI3 in skin cells remain unknown. In this study, it was found for the first time that LGI3 is expressed mostly by normal human keratinocytes. Furthermore, ELISA...

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Veröffentlicht in:	Experimental dermatology 2012-09, Vol.21 (9), p.716-718
Hauptverfasser:	Lee, Seung Hoon, Jeong, Yun-Mi, Kim, So-Young, Jeong, Hyo-Soon, Park, Kyoung-Chan, Baek, Kwang Jin, Kwon, Nyoun Soo, Yun, Hye-Young, Kim, Dong-Seok
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Survival - drug effects Cells, Cultured cytokine Dose-Response Relationship, Radiation Humans keratinocytes Keratinocytes - drug effects Keratinocytes - radiation effects Keratinocytes - secretion LGI3 Phosphorylation - drug effects Proteins - pharmacology Proteins - radiation effects Proteins - secretion Proto-Oncogene Proteins c-akt - drug effects Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-mdm2 - drug effects Proto-Oncogene Proteins c-mdm2 - metabolism Signal Transduction - drug effects skin Time Factors Tumor Suppressor Protein p53 - drug effects Tumor Suppressor Protein p53 - metabolism Ultraviolet Rays UVB
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