Convergent Syntheses of 3,6-Dihydroxydec-4-enolides
The total syntheses of the 3,6-dihydroxydecanolide from Cordyceps militaris and the novel C-3 epimer are reported using a diastereoselective Nozaki–Hiyama–Kishi reaction in the key cyclization to generate the 6R stereocenter.
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| Veröffentlicht in: | Organic letters 2012-08, Vol.14 (16), p.4194-4197 |
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| container_end_page | 4197 |
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| container_issue | 16 |
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| container_title | Organic letters |
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| creator | Killen, Jonathan C Axford, Lorraine C Newberry, Sarah E Simpson, Thomas J Willis, Christine L |
| description | The total syntheses of the 3,6-dihydroxydecanolide from Cordyceps militaris and the novel C-3 epimer are reported using a diastereoselective Nozaki–Hiyama–Kishi reaction in the key cyclization to generate the 6R stereocenter. |
| doi_str_mv | 10.1021/ol3018566 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1523-7060 |
| ispartof | Organic letters, 2012-08, Vol.14 (16), p.4194-4197 |
| issn | 1523-7060 1523-7052 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1034198779 |
| source | MEDLINE; American Chemical Society Journals |
| subjects | Biological Products - chemical synthesis Biological Products - chemistry Biological Products - isolation & purification Cordyceps - chemistry Cyclization Lactones - chemical synthesis Lactones - chemistry Lactones - isolation & purification Molecular Structure Stereoisomerism |
| title | Convergent Syntheses of 3,6-Dihydroxydec-4-enolides |
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