Total Hip Arthroplasty, Hip Osteoarthritis, Total Knee Arthroplasty, and Knee Osteoarthritis in Patients With Developmental Dysplasia of the Hip and Their Family Members: A Kinship Analysis Report
BACKGROUND:Developmental dysplasia of the hip (DDH) is a familial condition with a wide phenotypic expression. Families with high rates of DDH may have individuals with subtle phenotypic expression that can progress to osteoarthritis and require total hip arthroplasty (THA). This study compares the...
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| Veröffentlicht in: | Journal of pediatric orthopaedics 2012-09, Vol.32 (6), p.609-612 |
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| container_title | Journal of pediatric orthopaedics |
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| creator | Schiffern, Alison N Stevenson, David A Carroll, Kristen L Pimentel, Richard Mineau, Geraldine Viskochil, David H Roach, James W |
| description | BACKGROUND:Developmental dysplasia of the hip (DDH) is a familial condition with a wide phenotypic expression. Families with high rates of DDH may have individuals with subtle phenotypic expression that can progress to osteoarthritis and require total hip arthroplasty (THA). This study compares the rates of THA in relatives of individuals with DDH with individuals in control families.
METHODS:Probands with a diagnosis of DDH were identified using medical records linked to the Utah Population Database. Ten age-matched and sex-matched controls were randomly selected from a pool of unaffected individuals within the Utah Population Database. Diagnostic and procedural codes were used to determine the incidence of hip and knee osteoarthritis (HOA and KOA) and of THA and total knee arthroplasty (TKA) among the cases and controls and their relatives. Relative risks (RR) for HOA and KOA and for THA and TKA were calculated for the probands/controls and their family members.
RESULTS:The RR of HOA was significantly increased in probands (RR=82.4; P |
| doi_str_mv | 10.1097/BPO.0b013e31825fa7f2 |
| format | Article |
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METHODS:Probands with a diagnosis of DDH were identified using medical records linked to the Utah Population Database. Ten age-matched and sex-matched controls were randomly selected from a pool of unaffected individuals within the Utah Population Database. Diagnostic and procedural codes were used to determine the incidence of hip and knee osteoarthritis (HOA and KOA) and of THA and total knee arthroplasty (TKA) among the cases and controls and their relatives. Relative risks (RR) for HOA and KOA and for THA and TKA were calculated for the probands/controls and their family members.
RESULTS:The RR of HOA was significantly increased in probands (RR=82.4; P<2e-16), their parents (R=2.22; P=0.0003), and in their grandparents (RR=1.33; P=0.011). The RR of THA was also significantly increased in probands (RR=1168; P <3e-08) and in their grandparents (RR=2.06; P=0.01). The RR of KOA was significantly increased in probands with a diagnosis of DDH (RR=20.96; P=2.2e-8) but not in their parents or grandparents. The RR of TKA was also increased in probands alone (RR=57.47; P=1.7e-05).
CONCLUSIONS:Parents and grandparents of individuals with diagnosed DDH are significantly more likely to be diagnosed with HOA and undergo THA than members of the general population. These first-degree and second-degree relatives were not at higher risk for KOA or TKA. Given the known familial association of DDH, this association with osteoarthritis of the hip suggests a risk of undiagnosed hip dysplasia in individuals whose families have a high rate of DDH.
LEVEL OF EVIDENCE:Level III.</description><identifier>ISSN: 0271-6798</identifier><identifier>EISSN: 1539-2570</identifier><identifier>DOI: 10.1097/BPO.0b013e31825fa7f2</identifier><identifier>PMID: 22892624</identifier><identifier>CODEN: JPORDO</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Arthroplasty, Replacement, Hip - methods ; Arthroplasty, Replacement, Knee - methods ; Biological and medical sciences ; Case-Control Studies ; Child, Preschool ; Databases, Factual ; Diseases of the osteoarticular system ; Family Health - statistics & numerical data ; Female ; Hip Dislocation, Congenital - complications ; Hip Dislocation, Congenital - diagnosis ; Hip Dislocation, Congenital - epidemiology ; Humans ; Male ; Malformations and congenital and or hereditary diseases involving bones. Joint deformations ; Medical sciences ; Middle Aged ; Orthopedic surgery ; Osteoarthritis ; Osteoarthritis, Hip - epidemiology ; Osteoarthritis, Hip - etiology ; Osteoarthritis, Hip - surgery ; Osteoarthritis, Knee - epidemiology ; Osteoarthritis, Knee - etiology ; Osteoarthritis, Knee - surgery ; Risk ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Utah - epidemiology</subject><ispartof>Journal of pediatric orthopaedics, 2012-09, Vol.32 (6), p.609-612</ispartof><rights>2012 Lippincott Williams & Wilkins, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3312-a1f3abb5054cebb417d2604996fcb4ab821641957ffe91610814266a03f1b5a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26286990$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22892624$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schiffern, Alison N</creatorcontrib><creatorcontrib>Stevenson, David A</creatorcontrib><creatorcontrib>Carroll, Kristen L</creatorcontrib><creatorcontrib>Pimentel, Richard</creatorcontrib><creatorcontrib>Mineau, Geraldine</creatorcontrib><creatorcontrib>Viskochil, David H</creatorcontrib><creatorcontrib>Roach, James W</creatorcontrib><title>Total Hip Arthroplasty, Hip Osteoarthritis, Total Knee Arthroplasty, and Knee Osteoarthritis in Patients With Developmental Dysplasia of the Hip and Their Family Members: A Kinship Analysis Report</title><title>Journal of pediatric orthopaedics</title><addtitle>J Pediatr Orthop</addtitle><description>BACKGROUND:Developmental dysplasia of the hip (DDH) is a familial condition with a wide phenotypic expression. Families with high rates of DDH may have individuals with subtle phenotypic expression that can progress to osteoarthritis and require total hip arthroplasty (THA). This study compares the rates of THA in relatives of individuals with DDH with individuals in control families.
METHODS:Probands with a diagnosis of DDH were identified using medical records linked to the Utah Population Database. Ten age-matched and sex-matched controls were randomly selected from a pool of unaffected individuals within the Utah Population Database. Diagnostic and procedural codes were used to determine the incidence of hip and knee osteoarthritis (HOA and KOA) and of THA and total knee arthroplasty (TKA) among the cases and controls and their relatives. Relative risks (RR) for HOA and KOA and for THA and TKA were calculated for the probands/controls and their family members.
RESULTS:The RR of HOA was significantly increased in probands (RR=82.4; P<2e-16), their parents (R=2.22; P=0.0003), and in their grandparents (RR=1.33; P=0.011). The RR of THA was also significantly increased in probands (RR=1168; P <3e-08) and in their grandparents (RR=2.06; P=0.01). The RR of KOA was significantly increased in probands with a diagnosis of DDH (RR=20.96; P=2.2e-8) but not in their parents or grandparents. The RR of TKA was also increased in probands alone (RR=57.47; P=1.7e-05).
CONCLUSIONS:Parents and grandparents of individuals with diagnosed DDH are significantly more likely to be diagnosed with HOA and undergo THA than members of the general population. These first-degree and second-degree relatives were not at higher risk for KOA or TKA. Given the known familial association of DDH, this association with osteoarthritis of the hip suggests a risk of undiagnosed hip dysplasia in individuals whose families have a high rate of DDH.
LEVEL OF EVIDENCE:Level III.</description><subject>Arthroplasty, Replacement, Hip - methods</subject><subject>Arthroplasty, Replacement, Knee - methods</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Child, Preschool</subject><subject>Databases, Factual</subject><subject>Diseases of the osteoarticular system</subject><subject>Family Health - statistics & numerical data</subject><subject>Female</subject><subject>Hip Dislocation, Congenital - complications</subject><subject>Hip Dislocation, Congenital - diagnosis</subject><subject>Hip Dislocation, Congenital - epidemiology</subject><subject>Humans</subject><subject>Male</subject><subject>Malformations and congenital and or hereditary diseases involving bones. Joint deformations</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Orthopedic surgery</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis, Hip - epidemiology</subject><subject>Osteoarthritis, Hip - etiology</subject><subject>Osteoarthritis, Hip - surgery</subject><subject>Osteoarthritis, Knee - epidemiology</subject><subject>Osteoarthritis, Knee - etiology</subject><subject>Osteoarthritis, Knee - surgery</subject><subject>Risk</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Utah - epidemiology</subject><issn>0271-6798</issn><issn>1539-2570</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1u1DAUhSMEokPhDRDyBolFU_wXJ2Y3tJSiFk2FBrGMbjLXisH5wfZQ5f14MDydgYouLFtH3z3nyifLXjJ6yqgu376_WZ3ShjKBglW8MFAa_ihbsELonBclfZwtKC9ZrkpdHWXPQvhOKSuFFE-zI84rzRWXi-z3eozgyKWdyNLHzo-TgxDnkztlFSKOsJNttOGE7NmrAfEBDMNmL_8_QexAbiBaHGIg32zsyDn-QjdOfVKS0_kcdg4WyGhI7PAudOe17tB6cgG9dTP5jH2DPrwjS3Jlh9DtVh3AzSEFfMFp9PF59sSAC_jicB9nXy8-rM8u8-vVx09ny-u8FYLxHJgR0DQFLWSLTSNZueGKSq2VaRsJTcWZkkwXpTGomWK0YpIrBVQY1hSgxXH2Zu87-fHnFkOsextadA4GHLehZlQIVYlSq4TKPdr6MQSPpp687cHPCap3_dWpv_phf2ns1SFh2_S4-Tf0t7AEvD4AEFpwxsPQ2nDPKV4prel9_u3oYvq9H257i77uEFzsasq4ZEJXOU8vqimleTqMiz9lg7a_</recordid><startdate>201209</startdate><enddate>201209</enddate><creator>Schiffern, Alison N</creator><creator>Stevenson, David A</creator><creator>Carroll, Kristen L</creator><creator>Pimentel, Richard</creator><creator>Mineau, Geraldine</creator><creator>Viskochil, David H</creator><creator>Roach, James W</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201209</creationdate><title>Total Hip Arthroplasty, Hip Osteoarthritis, Total Knee Arthroplasty, and Knee Osteoarthritis in Patients With Developmental Dysplasia of the Hip and Their Family Members: A Kinship Analysis Report</title><author>Schiffern, Alison N ; Stevenson, David A ; Carroll, Kristen L ; Pimentel, Richard ; Mineau, Geraldine ; Viskochil, David H ; Roach, James W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3312-a1f3abb5054cebb417d2604996fcb4ab821641957ffe91610814266a03f1b5a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Arthroplasty, Replacement, Hip - methods</topic><topic>Arthroplasty, Replacement, Knee - methods</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Child, Preschool</topic><topic>Databases, Factual</topic><topic>Diseases of the osteoarticular system</topic><topic>Family Health - statistics & numerical data</topic><topic>Female</topic><topic>Hip Dislocation, Congenital - complications</topic><topic>Hip Dislocation, Congenital - diagnosis</topic><topic>Hip Dislocation, Congenital - epidemiology</topic><topic>Humans</topic><topic>Male</topic><topic>Malformations and congenital and or hereditary diseases involving bones. Joint deformations</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Orthopedic surgery</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis, Hip - epidemiology</topic><topic>Osteoarthritis, Hip - etiology</topic><topic>Osteoarthritis, Hip - surgery</topic><topic>Osteoarthritis, Knee - epidemiology</topic><topic>Osteoarthritis, Knee - etiology</topic><topic>Osteoarthritis, Knee - surgery</topic><topic>Risk</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Utah - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schiffern, Alison N</creatorcontrib><creatorcontrib>Stevenson, David A</creatorcontrib><creatorcontrib>Carroll, Kristen L</creatorcontrib><creatorcontrib>Pimentel, Richard</creatorcontrib><creatorcontrib>Mineau, Geraldine</creatorcontrib><creatorcontrib>Viskochil, David H</creatorcontrib><creatorcontrib>Roach, James W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric orthopaedics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schiffern, Alison N</au><au>Stevenson, David A</au><au>Carroll, Kristen L</au><au>Pimentel, Richard</au><au>Mineau, Geraldine</au><au>Viskochil, David H</au><au>Roach, James W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Total Hip Arthroplasty, Hip Osteoarthritis, Total Knee Arthroplasty, and Knee Osteoarthritis in Patients With Developmental Dysplasia of the Hip and Their Family Members: A Kinship Analysis Report</atitle><jtitle>Journal of pediatric orthopaedics</jtitle><addtitle>J Pediatr Orthop</addtitle><date>2012-09</date><risdate>2012</risdate><volume>32</volume><issue>6</issue><spage>609</spage><epage>612</epage><pages>609-612</pages><issn>0271-6798</issn><eissn>1539-2570</eissn><coden>JPORDO</coden><abstract>BACKGROUND:Developmental dysplasia of the hip (DDH) is a familial condition with a wide phenotypic expression. Families with high rates of DDH may have individuals with subtle phenotypic expression that can progress to osteoarthritis and require total hip arthroplasty (THA). This study compares the rates of THA in relatives of individuals with DDH with individuals in control families.
METHODS:Probands with a diagnosis of DDH were identified using medical records linked to the Utah Population Database. Ten age-matched and sex-matched controls were randomly selected from a pool of unaffected individuals within the Utah Population Database. Diagnostic and procedural codes were used to determine the incidence of hip and knee osteoarthritis (HOA and KOA) and of THA and total knee arthroplasty (TKA) among the cases and controls and their relatives. Relative risks (RR) for HOA and KOA and for THA and TKA were calculated for the probands/controls and their family members.
RESULTS:The RR of HOA was significantly increased in probands (RR=82.4; P<2e-16), their parents (R=2.22; P=0.0003), and in their grandparents (RR=1.33; P=0.011). The RR of THA was also significantly increased in probands (RR=1168; P <3e-08) and in their grandparents (RR=2.06; P=0.01). The RR of KOA was significantly increased in probands with a diagnosis of DDH (RR=20.96; P=2.2e-8) but not in their parents or grandparents. The RR of TKA was also increased in probands alone (RR=57.47; P=1.7e-05).
CONCLUSIONS:Parents and grandparents of individuals with diagnosed DDH are significantly more likely to be diagnosed with HOA and undergo THA than members of the general population. These first-degree and second-degree relatives were not at higher risk for KOA or TKA. Given the known familial association of DDH, this association with osteoarthritis of the hip suggests a risk of undiagnosed hip dysplasia in individuals whose families have a high rate of DDH.
LEVEL OF EVIDENCE:Level III.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>22892624</pmid><doi>10.1097/BPO.0b013e31825fa7f2</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of pediatric orthopaedics, 2012-09, Vol.32 (6), p.609-612 |
| issn | 0271-6798 1539-2570 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Arthroplasty, Replacement, Hip - methods Arthroplasty, Replacement, Knee - methods Biological and medical sciences Case-Control Studies Child, Preschool Databases, Factual Diseases of the osteoarticular system Family Health - statistics & numerical data Female Hip Dislocation, Congenital - complications Hip Dislocation, Congenital - diagnosis Hip Dislocation, Congenital - epidemiology Humans Male Malformations and congenital and or hereditary diseases involving bones. Joint deformations Medical sciences Middle Aged Orthopedic surgery Osteoarthritis Osteoarthritis, Hip - epidemiology Osteoarthritis, Hip - etiology Osteoarthritis, Hip - surgery Osteoarthritis, Knee - epidemiology Osteoarthritis, Knee - etiology Osteoarthritis, Knee - surgery Risk Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Utah - epidemiology |
| title | Total Hip Arthroplasty, Hip Osteoarthritis, Total Knee Arthroplasty, and Knee Osteoarthritis in Patients With Developmental Dysplasia of the Hip and Their Family Members: A Kinship Analysis Report |
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