Lipophilic Caffeic Acid Derivatives Protect Cells against H2O2‑Induced DNA Damage by Chelating Intracellular Labile Iron
Naturally occurring cinnamic acid derivatives are ubiquitously distributed in the plant kingdom, and it has been proposed that their consumption contributes to the maintenance of human health. However, the molecular mechanisms underlying their health keeping effects remain unknown. In the present in...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2012-08, Vol.60 (32), p.7873-7879 |
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| container_end_page | 7879 |
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| container_issue | 32 |
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| container_title | Journal of agricultural and food chemistry |
| container_volume | 60 |
| creator | Kitsati, Natalia Fokas, Demosthenes Ouzouni, Maria-Dimitra Mantzaris, Michalis D Barbouti, Alexandra Galaris, Dimitrios |
| description | Naturally occurring cinnamic acid derivatives are ubiquitously distributed in the plant kingdom, and it has been proposed that their consumption contributes to the maintenance of human health. However, the molecular mechanisms underlying their health keeping effects remain unknown. In the present investigation, we evaluated the capacity of several cinnamic acid derivatives (trans-cinnamic, p-coumaric, caffeic and ferulic acids, as well as caffeic acid-methyl and -propyl esters) to protect cells from oxidative stress-induced DNA damage. It was observed that effective protection was based on the ability of each compound to (i) reach the intracellular space and (ii) chelate intracellular “labile” iron. These results support the notion that numerous lipophilic iron chelating compounds, present abundantly in plant-derived diet components, may protect cells in conditions of oxidative stress and in this way be important contributors toward maintenance of human health. |
| doi_str_mv | 10.1021/jf301237y |
| format | Article |
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However, the molecular mechanisms underlying their health keeping effects remain unknown. In the present investigation, we evaluated the capacity of several cinnamic acid derivatives (trans-cinnamic, p-coumaric, caffeic and ferulic acids, as well as caffeic acid-methyl and -propyl esters) to protect cells from oxidative stress-induced DNA damage. It was observed that effective protection was based on the ability of each compound to (i) reach the intracellular space and (ii) chelate intracellular “labile” iron. These results support the notion that numerous lipophilic iron chelating compounds, present abundantly in plant-derived diet components, may protect cells in conditions of oxidative stress and in this way be important contributors toward maintenance of human health.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf301237y</identifier><identifier>PMID: 22827723</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Biological and medical sciences ; caffeic acid ; Caffeic Acids - pharmacology ; Cinnamates - pharmacology ; cinnamic acid ; Coumaric Acids - pharmacology ; DNA damage ; DNA Damage - drug effects ; esters ; Food industries ; Fundamental and applied biological sciences. Psychology ; Hep G2 Cells ; human health ; Humans ; Hydrogen Peroxide - pharmacology ; iron ; Iron Chelating Agents - pharmacology ; Jurkat Cells ; oxidative stress ; Oxidative Stress - drug effects</subject><ispartof>Journal of agricultural and food chemistry, 2012-08, Vol.60 (32), p.7873-7879</ispartof><rights>Copyright © 2012 American Chemical Society</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf301237y$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf301237y$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,27074,27922,27923,56736,56786</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26275412$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22827723$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kitsati, Natalia</creatorcontrib><creatorcontrib>Fokas, Demosthenes</creatorcontrib><creatorcontrib>Ouzouni, Maria-Dimitra</creatorcontrib><creatorcontrib>Mantzaris, Michalis D</creatorcontrib><creatorcontrib>Barbouti, Alexandra</creatorcontrib><creatorcontrib>Galaris, Dimitrios</creatorcontrib><title>Lipophilic Caffeic Acid Derivatives Protect Cells against H2O2‑Induced DNA Damage by Chelating Intracellular Labile Iron</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>Naturally occurring cinnamic acid derivatives are ubiquitously distributed in the plant kingdom, and it has been proposed that their consumption contributes to the maintenance of human health. However, the molecular mechanisms underlying their health keeping effects remain unknown. In the present investigation, we evaluated the capacity of several cinnamic acid derivatives (trans-cinnamic, p-coumaric, caffeic and ferulic acids, as well as caffeic acid-methyl and -propyl esters) to protect cells from oxidative stress-induced DNA damage. It was observed that effective protection was based on the ability of each compound to (i) reach the intracellular space and (ii) chelate intracellular “labile” iron. These results support the notion that numerous lipophilic iron chelating compounds, present abundantly in plant-derived diet components, may protect cells in conditions of oxidative stress and in this way be important contributors toward maintenance of human health.</description><subject>Biological and medical sciences</subject><subject>caffeic acid</subject><subject>Caffeic Acids - pharmacology</subject><subject>Cinnamates - pharmacology</subject><subject>cinnamic acid</subject><subject>Coumaric Acids - pharmacology</subject><subject>DNA damage</subject><subject>DNA Damage - drug effects</subject><subject>esters</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hep G2 Cells</subject><subject>human health</subject><subject>Humans</subject><subject>Hydrogen Peroxide - pharmacology</subject><subject>iron</subject><subject>Iron Chelating Agents - pharmacology</subject><subject>Jurkat Cells</subject><subject>oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkcFO20AQhldVqxJCD32Bdi-VuBhmZ72xfYwMlEhRqVQ4W7PrddjIsdNdGyk98Qq8Ik_CUkLLaQ7z_b_--YexzwJOBKA4XTcSBMps945NhEJIlBD5ezaBuExyNRMH7DCENQDkKoOP7AAxxyxDOWF_lm7bb29d6wwvqWlsnHPjan5mvbujwd3ZwH_6frBm4KVt28BpRa4LA7_EK3y8f1h09WhsFPyY8zPa0MpyvePlrW2julvxRTd4MlE5tuT5krRrLV_4vjtiHxpqg_20n1N2c3F-XV4my6vvi3K-TAhRDYmW8SQtdEGpoRylxtxYCUUhCyFFplLERoMWIFMta41EKi00pbUCSCGXcsqOX3y3vv892jBUGxeeA1Fn-zFUUSlnORaxwSn7skdHvbF1tfVuQ35XvfYVgW97gIKhtvHUGRf-czOMgf4afX3hGuorWvnI3PxCECmAEAWqN05kQrXuR9_FDmKW6vmj1b-PyicjC4zM</recordid><startdate>20120815</startdate><enddate>20120815</enddate><creator>Kitsati, Natalia</creator><creator>Fokas, Demosthenes</creator><creator>Ouzouni, Maria-Dimitra</creator><creator>Mantzaris, Michalis D</creator><creator>Barbouti, Alexandra</creator><creator>Galaris, Dimitrios</creator><general>American Chemical Society</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20120815</creationdate><title>Lipophilic Caffeic Acid Derivatives Protect Cells against H2O2‑Induced DNA Damage by Chelating Intracellular Labile Iron</title><author>Kitsati, Natalia ; Fokas, Demosthenes ; Ouzouni, Maria-Dimitra ; Mantzaris, Michalis D ; Barbouti, Alexandra ; Galaris, Dimitrios</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a225t-b3152b1b9a4ca823b28ce30993913175422fb0b1034b3db2aa549ba4d50040833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Biological and medical sciences</topic><topic>caffeic acid</topic><topic>Caffeic Acids - pharmacology</topic><topic>Cinnamates - pharmacology</topic><topic>cinnamic acid</topic><topic>Coumaric Acids - pharmacology</topic><topic>DNA damage</topic><topic>DNA Damage - drug effects</topic><topic>esters</topic><topic>Food industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hep G2 Cells</topic><topic>human health</topic><topic>Humans</topic><topic>Hydrogen Peroxide - pharmacology</topic><topic>iron</topic><topic>Iron Chelating Agents - pharmacology</topic><topic>Jurkat Cells</topic><topic>oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kitsati, Natalia</creatorcontrib><creatorcontrib>Fokas, Demosthenes</creatorcontrib><creatorcontrib>Ouzouni, Maria-Dimitra</creatorcontrib><creatorcontrib>Mantzaris, Michalis D</creatorcontrib><creatorcontrib>Barbouti, Alexandra</creatorcontrib><creatorcontrib>Galaris, Dimitrios</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kitsati, Natalia</au><au>Fokas, Demosthenes</au><au>Ouzouni, Maria-Dimitra</au><au>Mantzaris, Michalis D</au><au>Barbouti, Alexandra</au><au>Galaris, Dimitrios</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipophilic Caffeic Acid Derivatives Protect Cells against H2O2‑Induced DNA Damage by Chelating Intracellular Labile Iron</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2012-08-15</date><risdate>2012</risdate><volume>60</volume><issue>32</issue><spage>7873</spage><epage>7879</epage><pages>7873-7879</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>Naturally occurring cinnamic acid derivatives are ubiquitously distributed in the plant kingdom, and it has been proposed that their consumption contributes to the maintenance of human health. However, the molecular mechanisms underlying their health keeping effects remain unknown. In the present investigation, we evaluated the capacity of several cinnamic acid derivatives (trans-cinnamic, p-coumaric, caffeic and ferulic acids, as well as caffeic acid-methyl and -propyl esters) to protect cells from oxidative stress-induced DNA damage. It was observed that effective protection was based on the ability of each compound to (i) reach the intracellular space and (ii) chelate intracellular “labile” iron. 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| ispartof | Journal of agricultural and food chemistry, 2012-08, Vol.60 (32), p.7873-7879 |
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| source | MEDLINE; ACS Publications |
| subjects | Biological and medical sciences caffeic acid Caffeic Acids - pharmacology Cinnamates - pharmacology cinnamic acid Coumaric Acids - pharmacology DNA damage DNA Damage - drug effects esters Food industries Fundamental and applied biological sciences. Psychology Hep G2 Cells human health Humans Hydrogen Peroxide - pharmacology iron Iron Chelating Agents - pharmacology Jurkat Cells oxidative stress Oxidative Stress - drug effects |
| title | Lipophilic Caffeic Acid Derivatives Protect Cells against H2O2‑Induced DNA Damage by Chelating Intracellular Labile Iron |
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