α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB)

γ-Hydroxybutyric acid (GHB) binding to brain-specific high-affinity sites is well-established and proposed to explain both physiological and pharmacological actions. However, the mechanistic links between these lines of data are unknown. To identify molecular targets for specific GHB high-affinity b...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-08, Vol.109 (33), p.13404-13409
Hauptverfasser:	Absalom, Nathan, Eghorn, Laura F, Villumsen, Inge S, Karim, Nasiara, Bay, Tina, Olsen, Jesper V, Knudsen, Gitte M, Bräuner-Osborne, Hans, Frølund, Bente, Clausen, Rasmus P, Chebib, Mary, Wellendorph, Petrine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzocycloheptenes - pharmacology Binding Sites Brain - drug effects Brain - metabolism Electrodes Humans Hydroxybutyrates - metabolism Mice Mice, Knockout Patch-Clamp Techniques Photoaffinity Labels Point Mutation - genetics Protein Binding - drug effects Protein Subunits - metabolism Proteomics Pyridazines - pharmacology Radioligand Assay Rats Receptors, GABA-A - isolation & purification Receptors, GABA-A - metabolism Recombinant Proteins - agonists Recombinant Proteins - metabolism Xenopus laevis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!