Activation Level of JNK and Akt/ERK Signaling Pathways Determinates Extent of DNA Damage in the Liver of Diabetic Rats

Aims: Diabetes-related oxidative stress conditions lead to progressive tissue damage and disfunctionality. Mechanisms underlying liver pathophysiology during diabetes are not fully understood. The aim of this study was to find relationship between diabetes-related DNA damage in the rat liver and act...

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Veröffentlicht in:	Cellular physiology and biochemistry 2012-01, Vol.30 (3), p.723-734
Hauptverfasser:	Martinović, Vesna, Grigorov, Ilijana, Bogojević, Desanka, Petrović, Anja, Jovanović, Sofija, Ilić, Mirka, Ivanović Matić, Svetlana
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Catalase - metabolism Comet Assay Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology DNA Damage Glutathione Transferase - metabolism Hydrogen Peroxide - blood JNK Mitogen-Activated Protein Kinases - metabolism Liver - drug effects Liver - enzymology Liver - metabolism Male Mitogen-Activated Protein Kinase 3 - metabolism Original Paper p38 Mitogen-Activated Protein Kinases - metabolism Rats Rats, Wistar Signal Transduction Singlet Oxygen - blood STAT3 Transcription Factor - metabolism Superoxide Dismutase - metabolism Transcription Factor RelA - metabolism
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