Nifedipine versus labetalol in the treatment of hypertensive disorders of pregnancy
Purpose To assess the maternal and fetal outcomes of pregnancies affected by hypertensive disorders treated with nifedipine versus labetalol. Methods A retrospective study in hypertensive patients treated during pregnancy with nifedipine or labetalol was conducted. After the charts review the patien...
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| Veröffentlicht in: | Archives of gynecology and obstetrics 2012-09, Vol.286 (3), p.637-642 |
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| container_title | Archives of gynecology and obstetrics |
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| creator | Giannubilo, Stefano R. Bezzeccheri, Valeria Cecchi, Stefano Landi, Beatrice Battistoni, Giovanna I. Vitali, Paola Cecchi, Lucia Tranquilli, Andrea L. |
| description | Purpose
To assess the maternal and fetal outcomes of pregnancies affected by hypertensive disorders treated with nifedipine versus labetalol.
Methods
A retrospective study in hypertensive patients treated during pregnancy with nifedipine or labetalol was conducted. After the charts review the patients were divided in the four groups: gestational hypertension (113 patients); mild preeclampsia (77 patients); severe preeclampsia (31 patients); HELLP syndrome (21 patients). The pregnancy and neonatal records were analyzed by paired and unpaired
t
test.
Results
We found that there was an higher rate of intrauterine growth restriction infants among women treated with labetalol compared with those treated with nifedipine (38.8 vs. 15.5 %;
p
|
| doi_str_mv | 10.1007/s00404-012-2371-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1033534607</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2261876640</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-d1e3d3c6f86ab43b6c4171638df36d9ae13611a7b269124f1f452ba9a2c583073</originalsourceid><addsrcrecordid>eNp1kE1LxDAQhoMouq7-AC9S8OKlmknSJHsU8QtED-o5pO10t9JNa9KK--_N2lVB8DSBed53wkPIEdAzoFSdB0oFFSkFljKuIP3YIhMQnKVUAWyTCZ2t31SqPbIfwiuNoNZyl-wxlmngWk_I00NdYVl3tcPkHX0YQtLYHHvbtE1Su6RfYNJ7tP0SXZ-0VbJYdeh7dKF-x6SsQ-vLGFtvOo9zZ12xOiA7lW0CHm7mlLxcXz1f3qb3jzd3lxf3acEV69MSkJe8kJWWNhc8l4UABZLrsuKynFkELgGsypmcARMVVCJjuZ1ZVmSaU8Wn5HTs7Xz7NmDozbIOBTaNddgOwQDlPONCfqEnf9DXdvAu_s4wJkErKQWNFIxU4dsQPFam8_XS-lWsMmvjZjRuokizNm4-YuZ40zzkSyx_Et-KI8BGIMSVm6P_Pf1_6yejhIui</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2261876640</pqid></control><display><type>article</type><title>Nifedipine versus labetalol in the treatment of hypertensive disorders of pregnancy</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Giannubilo, Stefano R. ; Bezzeccheri, Valeria ; Cecchi, Stefano ; Landi, Beatrice ; Battistoni, Giovanna I. ; Vitali, Paola ; Cecchi, Lucia ; Tranquilli, Andrea L.</creator><creatorcontrib>Giannubilo, Stefano R. ; Bezzeccheri, Valeria ; Cecchi, Stefano ; Landi, Beatrice ; Battistoni, Giovanna I. ; Vitali, Paola ; Cecchi, Lucia ; Tranquilli, Andrea L.</creatorcontrib><description>Purpose
To assess the maternal and fetal outcomes of pregnancies affected by hypertensive disorders treated with nifedipine versus labetalol.
Methods
A retrospective study in hypertensive patients treated during pregnancy with nifedipine or labetalol was conducted. After the charts review the patients were divided in the four groups: gestational hypertension (113 patients); mild preeclampsia (77 patients); severe preeclampsia (31 patients); HELLP syndrome (21 patients). The pregnancy and neonatal records were analyzed by paired and unpaired
t
test.
Results
We found that there was an higher rate of intrauterine growth restriction infants among women treated with labetalol compared with those treated with nifedipine (38.8 vs. 15.5 %;
p
< 0.05), but only in the subgroup of women affected by Gestational Hypertension and Mild Preeclampsia. In this group was also higher the rate of fetal worsening assessed by fetal heart rate tracing (33.3 vs. 14.2 %;
p
< 0.05). No neonatal malformations and no differences in the rate of adverse side effects were observed.
Conclusions
Antihypertensive therapy in pregnancy with Labetalol may have the potential to impair fetal behavior in low degrees hypertensive diseases of pregnancy. Optimal care must balance the potentially conflicting risks and benefits to mother and fetus.</description><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-012-2371-x</identifier><identifier>PMID: 22581388</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adrenergic beta-Antagonists - therapeutic use ; Calcium Channel Blockers - therapeutic use ; Endocrinology ; Female ; Gynecology ; Human Genetics ; Humans ; Hypertension ; Hypertension, Pregnancy-Induced - drug therapy ; Labetalol - therapeutic use ; Maternal-Fetal Medicine ; Medicine ; Medicine & Public Health ; Nifedipine - therapeutic use ; Obstetrics/Perinatology/Midwifery ; Preeclampsia ; Pregnancy ; Pregnancy Outcome ; Retrospective Studies</subject><ispartof>Archives of gynecology and obstetrics, 2012-09, Vol.286 (3), p.637-642</ispartof><rights>Springer-Verlag 2012</rights><rights>Archives of Gynecology and Obstetrics is a copyright of Springer, (2012). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-d1e3d3c6f86ab43b6c4171638df36d9ae13611a7b269124f1f452ba9a2c583073</citedby><cites>FETCH-LOGICAL-c372t-d1e3d3c6f86ab43b6c4171638df36d9ae13611a7b269124f1f452ba9a2c583073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00404-012-2371-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00404-012-2371-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22581388$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giannubilo, Stefano R.</creatorcontrib><creatorcontrib>Bezzeccheri, Valeria</creatorcontrib><creatorcontrib>Cecchi, Stefano</creatorcontrib><creatorcontrib>Landi, Beatrice</creatorcontrib><creatorcontrib>Battistoni, Giovanna I.</creatorcontrib><creatorcontrib>Vitali, Paola</creatorcontrib><creatorcontrib>Cecchi, Lucia</creatorcontrib><creatorcontrib>Tranquilli, Andrea L.</creatorcontrib><title>Nifedipine versus labetalol in the treatment of hypertensive disorders of pregnancy</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Purpose
To assess the maternal and fetal outcomes of pregnancies affected by hypertensive disorders treated with nifedipine versus labetalol.
Methods
A retrospective study in hypertensive patients treated during pregnancy with nifedipine or labetalol was conducted. After the charts review the patients were divided in the four groups: gestational hypertension (113 patients); mild preeclampsia (77 patients); severe preeclampsia (31 patients); HELLP syndrome (21 patients). The pregnancy and neonatal records were analyzed by paired and unpaired
t
test.
Results
We found that there was an higher rate of intrauterine growth restriction infants among women treated with labetalol compared with those treated with nifedipine (38.8 vs. 15.5 %;
p
< 0.05), but only in the subgroup of women affected by Gestational Hypertension and Mild Preeclampsia. In this group was also higher the rate of fetal worsening assessed by fetal heart rate tracing (33.3 vs. 14.2 %;
p
< 0.05). No neonatal malformations and no differences in the rate of adverse side effects were observed.
Conclusions
Antihypertensive therapy in pregnancy with Labetalol may have the potential to impair fetal behavior in low degrees hypertensive diseases of pregnancy. Optimal care must balance the potentially conflicting risks and benefits to mother and fetus.</description><subject>Adrenergic beta-Antagonists - therapeutic use</subject><subject>Calcium Channel Blockers - therapeutic use</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension, Pregnancy-Induced - drug therapy</subject><subject>Labetalol - therapeutic use</subject><subject>Maternal-Fetal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nifedipine - therapeutic use</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Retrospective Studies</subject><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1LxDAQhoMouq7-AC9S8OKlmknSJHsU8QtED-o5pO10t9JNa9KK--_N2lVB8DSBed53wkPIEdAzoFSdB0oFFSkFljKuIP3YIhMQnKVUAWyTCZ2t31SqPbIfwiuNoNZyl-wxlmngWk_I00NdYVl3tcPkHX0YQtLYHHvbtE1Su6RfYNJ7tP0SXZ-0VbJYdeh7dKF-x6SsQ-vLGFtvOo9zZ12xOiA7lW0CHm7mlLxcXz1f3qb3jzd3lxf3acEV69MSkJe8kJWWNhc8l4UABZLrsuKynFkELgGsypmcARMVVCJjuZ1ZVmSaU8Wn5HTs7Xz7NmDozbIOBTaNddgOwQDlPONCfqEnf9DXdvAu_s4wJkErKQWNFIxU4dsQPFam8_XS-lWsMmvjZjRuokizNm4-YuZ40zzkSyx_Et-KI8BGIMSVm6P_Pf1_6yejhIui</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Giannubilo, Stefano R.</creator><creator>Bezzeccheri, Valeria</creator><creator>Cecchi, Stefano</creator><creator>Landi, Beatrice</creator><creator>Battistoni, Giovanna I.</creator><creator>Vitali, Paola</creator><creator>Cecchi, Lucia</creator><creator>Tranquilli, Andrea L.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20120901</creationdate><title>Nifedipine versus labetalol in the treatment of hypertensive disorders of pregnancy</title><author>Giannubilo, Stefano R. ; Bezzeccheri, Valeria ; Cecchi, Stefano ; Landi, Beatrice ; Battistoni, Giovanna I. ; Vitali, Paola ; Cecchi, Lucia ; Tranquilli, Andrea L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-d1e3d3c6f86ab43b6c4171638df36d9ae13611a7b269124f1f452ba9a2c583073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adrenergic beta-Antagonists - therapeutic use</topic><topic>Calcium Channel Blockers - therapeutic use</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension, Pregnancy-Induced - drug therapy</topic><topic>Labetalol - therapeutic use</topic><topic>Maternal-Fetal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nifedipine - therapeutic use</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giannubilo, Stefano R.</creatorcontrib><creatorcontrib>Bezzeccheri, Valeria</creatorcontrib><creatorcontrib>Cecchi, Stefano</creatorcontrib><creatorcontrib>Landi, Beatrice</creatorcontrib><creatorcontrib>Battistoni, Giovanna I.</creatorcontrib><creatorcontrib>Vitali, Paola</creatorcontrib><creatorcontrib>Cecchi, Lucia</creatorcontrib><creatorcontrib>Tranquilli, Andrea L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giannubilo, Stefano R.</au><au>Bezzeccheri, Valeria</au><au>Cecchi, Stefano</au><au>Landi, Beatrice</au><au>Battistoni, Giovanna I.</au><au>Vitali, Paola</au><au>Cecchi, Lucia</au><au>Tranquilli, Andrea L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nifedipine versus labetalol in the treatment of hypertensive disorders of pregnancy</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>286</volume><issue>3</issue><spage>637</spage><epage>642</epage><pages>637-642</pages><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract>Purpose
To assess the maternal and fetal outcomes of pregnancies affected by hypertensive disorders treated with nifedipine versus labetalol.
Methods
A retrospective study in hypertensive patients treated during pregnancy with nifedipine or labetalol was conducted. After the charts review the patients were divided in the four groups: gestational hypertension (113 patients); mild preeclampsia (77 patients); severe preeclampsia (31 patients); HELLP syndrome (21 patients). The pregnancy and neonatal records were analyzed by paired and unpaired
t
test.
Results
We found that there was an higher rate of intrauterine growth restriction infants among women treated with labetalol compared with those treated with nifedipine (38.8 vs. 15.5 %;
p
< 0.05), but only in the subgroup of women affected by Gestational Hypertension and Mild Preeclampsia. In this group was also higher the rate of fetal worsening assessed by fetal heart rate tracing (33.3 vs. 14.2 %;
p
< 0.05). No neonatal malformations and no differences in the rate of adverse side effects were observed.
Conclusions
Antihypertensive therapy in pregnancy with Labetalol may have the potential to impair fetal behavior in low degrees hypertensive diseases of pregnancy. Optimal care must balance the potentially conflicting risks and benefits to mother and fetus.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22581388</pmid><doi>10.1007/s00404-012-2371-x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0932-0067 |
| ispartof | Archives of gynecology and obstetrics, 2012-09, Vol.286 (3), p.637-642 |
| issn | 0932-0067 1432-0711 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adrenergic beta-Antagonists - therapeutic use Calcium Channel Blockers - therapeutic use Endocrinology Female Gynecology Human Genetics Humans Hypertension Hypertension, Pregnancy-Induced - drug therapy Labetalol - therapeutic use Maternal-Fetal Medicine Medicine Medicine & Public Health Nifedipine - therapeutic use Obstetrics/Perinatology/Midwifery Preeclampsia Pregnancy Pregnancy Outcome Retrospective Studies |
| title | Nifedipine versus labetalol in the treatment of hypertensive disorders of pregnancy |
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