Switch-associated protein 70 antibodies in multiple sclerosis: relationship between increased serum levels and clinical relapse
Objective To identify an antibody biomarker for multiple sclerosis (MS) that can be used as a predictor of MS relapses. Methods MS patients’ sera were screened by a protein macroarray derived from human fetal brain cDNA library (hEX1). Sera of 90 consecutive relapsing remitting MS (RRMS) patients an...
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| Veröffentlicht in: | Inflammation research 2012-09, Vol.61 (9), p.927-930 |
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| creator | Erdağ, Ece Tüzün, Erdem Uğurel, Elif Çavuş, Filiz Şehitoğlu, Elçin Giriş, Murat Vural, Burçak Eraksoy, Mefküre Akman-Demir, Gülşen |
| description | Objective
To identify an antibody biomarker for multiple sclerosis (MS) that can be used as a predictor of MS relapses.
Methods
MS patients’ sera were screened by a protein macroarray derived from human fetal brain cDNA library (hEX1). Sera of 90 consecutive relapsing remitting MS (RRMS) patients and age-matched 145 Behçet’s disease (BD) patients, 40 infectious meningoencephalitis patients, and 70 healthy controls were screened by ELISA for serum antibodies against the selected clone.
Results
Sequencing of the clone with the highest signal intensity revealed switch-associated protein 70 (SWAP70) as a potential target autoantigen in RRMS. ELISA studies showed high-titer SWAP70-antibodies in 21 (23.3 %) RRMS and 7 (4.8 %) BD patients. SWAP70 antibodies were more likely to be found positive in sera obtained during or shortly after a relapse.
Conclusion
Detection of SWAP70 antibodies during the attack period might suggest that SWAP70 is involved in MS relapse pathogenesis. Whether serum SWAP70 antibody detection may be utilized as an MS relapse predictor should be tested in prospective studies. |
| doi_str_mv | 10.1007/s00011-012-0488-9 |
| format | Article |
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To identify an antibody biomarker for multiple sclerosis (MS) that can be used as a predictor of MS relapses.
Methods
MS patients’ sera were screened by a protein macroarray derived from human fetal brain cDNA library (hEX1). Sera of 90 consecutive relapsing remitting MS (RRMS) patients and age-matched 145 Behçet’s disease (BD) patients, 40 infectious meningoencephalitis patients, and 70 healthy controls were screened by ELISA for serum antibodies against the selected clone.
Results
Sequencing of the clone with the highest signal intensity revealed switch-associated protein 70 (SWAP70) as a potential target autoantigen in RRMS. ELISA studies showed high-titer SWAP70-antibodies in 21 (23.3 %) RRMS and 7 (4.8 %) BD patients. SWAP70 antibodies were more likely to be found positive in sera obtained during or shortly after a relapse.
Conclusion
Detection of SWAP70 antibodies during the attack period might suggest that SWAP70 is involved in MS relapse pathogenesis. Whether serum SWAP70 antibody detection may be utilized as an MS relapse predictor should be tested in prospective studies.</description><identifier>ISSN: 1023-3830</identifier><identifier>EISSN: 1420-908X</identifier><identifier>DOI: 10.1007/s00011-012-0488-9</identifier><identifier>PMID: 22728961</identifier><language>eng</language><publisher>Basel: SP Birkhäuser Verlag Basel</publisher><subject>Adult ; Allergology ; Antibodies - blood ; Antibodies - immunology ; Behcet Syndrome - blood ; Behcet Syndrome - immunology ; Biomedical and Life Sciences ; Biomedicine ; Case-Control Studies ; Dermatology ; DNA-Binding Proteins - immunology ; Female ; Guanine Nucleotide Exchange Factors - immunology ; Humans ; Immunology ; Male ; Meningoencephalitis - blood ; Meningoencephalitis - immunology ; Minor Histocompatibility Antigens ; Multiple Sclerosis, Relapsing-Remitting - blood ; Multiple Sclerosis, Relapsing-Remitting - immunology ; Neurology ; Nuclear Proteins - immunology ; Pharmacology/Toxicology ; Recurrence ; Rheumatology ; Short Communication</subject><ispartof>Inflammation research, 2012-09, Vol.61 (9), p.927-930</ispartof><rights>Springer Basel AG 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-8ac4dc98b955fe97cc75c87292cf9f2ae40a65383ff41ddfddf9212a41fe26333</citedby><cites>FETCH-LOGICAL-c372t-8ac4dc98b955fe97cc75c87292cf9f2ae40a65383ff41ddfddf9212a41fe26333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00011-012-0488-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00011-012-0488-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22728961$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Erdağ, Ece</creatorcontrib><creatorcontrib>Tüzün, Erdem</creatorcontrib><creatorcontrib>Uğurel, Elif</creatorcontrib><creatorcontrib>Çavuş, Filiz</creatorcontrib><creatorcontrib>Şehitoğlu, Elçin</creatorcontrib><creatorcontrib>Giriş, Murat</creatorcontrib><creatorcontrib>Vural, Burçak</creatorcontrib><creatorcontrib>Eraksoy, Mefküre</creatorcontrib><creatorcontrib>Akman-Demir, Gülşen</creatorcontrib><title>Switch-associated protein 70 antibodies in multiple sclerosis: relationship between increased serum levels and clinical relapse</title><title>Inflammation research</title><addtitle>Inflamm. Res</addtitle><addtitle>Inflamm Res</addtitle><description>Objective
To identify an antibody biomarker for multiple sclerosis (MS) that can be used as a predictor of MS relapses.
Methods
MS patients’ sera were screened by a protein macroarray derived from human fetal brain cDNA library (hEX1). Sera of 90 consecutive relapsing remitting MS (RRMS) patients and age-matched 145 Behçet’s disease (BD) patients, 40 infectious meningoencephalitis patients, and 70 healthy controls were screened by ELISA for serum antibodies against the selected clone.
Results
Sequencing of the clone with the highest signal intensity revealed switch-associated protein 70 (SWAP70) as a potential target autoantigen in RRMS. ELISA studies showed high-titer SWAP70-antibodies in 21 (23.3 %) RRMS and 7 (4.8 %) BD patients. SWAP70 antibodies were more likely to be found positive in sera obtained during or shortly after a relapse.
Conclusion
Detection of SWAP70 antibodies during the attack period might suggest that SWAP70 is involved in MS relapse pathogenesis. Whether serum SWAP70 antibody detection may be utilized as an MS relapse predictor should be tested in prospective studies.</description><subject>Adult</subject><subject>Allergology</subject><subject>Antibodies - blood</subject><subject>Antibodies - immunology</subject><subject>Behcet Syndrome - blood</subject><subject>Behcet Syndrome - immunology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Case-Control Studies</subject><subject>Dermatology</subject><subject>DNA-Binding Proteins - immunology</subject><subject>Female</subject><subject>Guanine Nucleotide Exchange Factors - immunology</subject><subject>Humans</subject><subject>Immunology</subject><subject>Male</subject><subject>Meningoencephalitis - blood</subject><subject>Meningoencephalitis - immunology</subject><subject>Minor Histocompatibility Antigens</subject><subject>Multiple Sclerosis, Relapsing-Remitting - blood</subject><subject>Multiple Sclerosis, Relapsing-Remitting - immunology</subject><subject>Neurology</subject><subject>Nuclear Proteins - immunology</subject><subject>Pharmacology/Toxicology</subject><subject>Recurrence</subject><subject>Rheumatology</subject><subject>Short Communication</subject><issn>1023-3830</issn><issn>1420-908X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kUuLFTEQhYMozjj6A9xIwI2baB7dN4k7GXzBgAsV3DW56YqTIf0wlXZw5V-37txRRBACCanvnFTlMPZYyedKSvsCpZRKCam0kJ1zwt9hp6rTUnjpvtyls9RGGGfkCXuAeEW0007fZydaW-38Tp2ynx-vc4uXIiAuMYcGI1_r0iDP3Eoe5pb3y5gBOV1MW2l5LcAxFqgLZnzJK5TQ8jLjZV75Hto1wExsrBCQvBDqNvEC36EguY08ljznGMqNcEV4yO6lUBAe3e5n7POb15_O34mLD2_fn7-6ENFY3YQLsRujd3vf9wm8jdH20VntdUw-6QCdDLueRk2pU-OYaHmtdOhUAr0zxpyxZ0dfmu7bBtiGKWOEUsIMy4aDksb0puutI_TpP-jVstWZujtQVlvZ3VDqSEX6CayQhrXmKdQfBA2HdIZjOgOlMxzSGTxpntw6b_sJxj-K33EQoI8AUmn-CvXvp__n-gtYB5yI</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Erdağ, Ece</creator><creator>Tüzün, Erdem</creator><creator>Uğurel, Elif</creator><creator>Çavuş, Filiz</creator><creator>Şehitoğlu, Elçin</creator><creator>Giriş, Murat</creator><creator>Vural, Burçak</creator><creator>Eraksoy, Mefküre</creator><creator>Akman-Demir, Gülşen</creator><general>SP Birkhäuser Verlag Basel</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20120901</creationdate><title>Switch-associated protein 70 antibodies in multiple sclerosis: relationship between increased serum levels and clinical relapse</title><author>Erdağ, Ece ; 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Res</stitle><addtitle>Inflamm Res</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>61</volume><issue>9</issue><spage>927</spage><epage>930</epage><pages>927-930</pages><issn>1023-3830</issn><eissn>1420-908X</eissn><abstract>Objective
To identify an antibody biomarker for multiple sclerosis (MS) that can be used as a predictor of MS relapses.
Methods
MS patients’ sera were screened by a protein macroarray derived from human fetal brain cDNA library (hEX1). Sera of 90 consecutive relapsing remitting MS (RRMS) patients and age-matched 145 Behçet’s disease (BD) patients, 40 infectious meningoencephalitis patients, and 70 healthy controls were screened by ELISA for serum antibodies against the selected clone.
Results
Sequencing of the clone with the highest signal intensity revealed switch-associated protein 70 (SWAP70) as a potential target autoantigen in RRMS. ELISA studies showed high-titer SWAP70-antibodies in 21 (23.3 %) RRMS and 7 (4.8 %) BD patients. SWAP70 antibodies were more likely to be found positive in sera obtained during or shortly after a relapse.
Conclusion
Detection of SWAP70 antibodies during the attack period might suggest that SWAP70 is involved in MS relapse pathogenesis. Whether serum SWAP70 antibody detection may be utilized as an MS relapse predictor should be tested in prospective studies.</abstract><cop>Basel</cop><pub>SP Birkhäuser Verlag Basel</pub><pmid>22728961</pmid><doi>10.1007/s00011-012-0488-9</doi><tpages>4</tpages></addata></record> |
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| ispartof | Inflammation research, 2012-09, Vol.61 (9), p.927-930 |
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| subjects | Adult Allergology Antibodies - blood Antibodies - immunology Behcet Syndrome - blood Behcet Syndrome - immunology Biomedical and Life Sciences Biomedicine Case-Control Studies Dermatology DNA-Binding Proteins - immunology Female Guanine Nucleotide Exchange Factors - immunology Humans Immunology Male Meningoencephalitis - blood Meningoencephalitis - immunology Minor Histocompatibility Antigens Multiple Sclerosis, Relapsing-Remitting - blood Multiple Sclerosis, Relapsing-Remitting - immunology Neurology Nuclear Proteins - immunology Pharmacology/Toxicology Recurrence Rheumatology Short Communication |
| title | Switch-associated protein 70 antibodies in multiple sclerosis: relationship between increased serum levels and clinical relapse |
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