HPLC analysis of naturally occurring free d-amino acids in mammals
d-Amino acids are currently recognized as naturally occurring physiologically active substances and biomarkers in mammals. The progress of analytical technologies, mostly high resolution chromatographic or electrodriven separation methods, has significantly contributed to the advances in d-amino aci...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 2012-10, Vol.69, p.42-49 |
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| container_title | Journal of pharmaceutical and biomedical analysis |
| container_volume | 69 |
| creator | Miyoshi, Yurika Koga, Reiko Oyama, Tsubasa Han, Hai Ueno, Kyoko Masuyama, Kei Itoh, Yusuke Hamase, Kenji |
| description | d-Amino acids are currently recognized as naturally occurring physiologically active substances and biomarkers in mammals. The progress of analytical technologies, mostly high resolution chromatographic or electrodriven separation methods, has significantly contributed to the advances in d-amino acid research in real biological matrices. In this review, we would like to describe the d-amino acid research, from the discovery of appreciable amounts of free d-amino acids in mammals to the current metabolomics study focusing on amino acid enantiomers. The liquid phase enantioselective analytical methods utilized for the determination of d-amino acids in mammals including human beings will be discussed. |
| doi_str_mv | 10.1016/j.jpba.2012.01.041 |
| format | Article |
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The progress of analytical technologies, mostly high resolution chromatographic or electrodriven separation methods, has significantly contributed to the advances in d-amino acid research in real biological matrices. In this review, we would like to describe the d-amino acid research, from the discovery of appreciable amounts of free d-amino acids in mammals to the current metabolomics study focusing on amino acid enantiomers. The liquid phase enantioselective analytical methods utilized for the determination of d-amino acids in mammals including human beings will be discussed.</description><identifier>ISSN: 0731-7085</identifier><identifier>EISSN: 1873-264X</identifier><identifier>DOI: 10.1016/j.jpba.2012.01.041</identifier><identifier>PMID: 22386210</identifier><identifier>CODEN: JPBADA</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Amino Acids - chemistry ; Analysis ; Analytical, structural and metabolic biochemistry ; Animals ; Biological and medical sciences ; Biomarkers - metabolism ; Brain - metabolism ; Chemistry Techniques, Analytical ; Chiral analysis ; Chromatography - methods ; Chromatography, Gas - methods ; Chromatography, High Pressure Liquid - methods ; d-Amino acids ; Electrochemistry - methods ; Fundamental and applied biological sciences. 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The progress of analytical technologies, mostly high resolution chromatographic or electrodriven separation methods, has significantly contributed to the advances in d-amino acid research in real biological matrices. In this review, we would like to describe the d-amino acid research, from the discovery of appreciable amounts of free d-amino acids in mammals to the current metabolomics study focusing on amino acid enantiomers. The liquid phase enantioselective analytical methods utilized for the determination of d-amino acids in mammals including human beings will be discussed.</description><subject>Amino Acids - chemistry</subject><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - metabolism</subject><subject>Brain - metabolism</subject><subject>Chemistry Techniques, Analytical</subject><subject>Chiral analysis</subject><subject>Chromatography - methods</subject><subject>Chromatography, Gas - methods</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>d-Amino acids</subject><subject>Electrochemistry - methods</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>HPLC</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Metabolomics - methods</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Stereoisomerism</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90E1r3DAQgGFRWrrbpH8gh6BLIRe7I8mWbMglWdJsYaE5JNCbGOsjyPhjI60L--_jZTfJrae5PDMMLyEXDHIGTP5s83bbYM6B8RxYDgX7RJasUiLjsvj7mSxBCZYpqMoF-ZZSCwAlq4uvZMG5qCRnsCS364fNiuKA3T6FREdPB9xNEbtuT0djphjD8Ex9dI7aDPswjBRNsImGgfbY99ilc_LFz8N9P80z8vTr7nG1zjZ_7n-vbjaZKUq-y5jEUhglveIKasFqtNIqQKVEpaypedl46xteexAga-aEr2ThjTUguaqVOCNXx7vbOL5MLu10H5JxXYeDG6ekGQhRCl7LYqb8SE0cU4rO620MPcb9jPShnW71oZ0-tNPA9NxuXro83Z-a3tn3lbdYM_hxApgMdj7iYEL6cFIIzksxu-ujc3ONf8FFnUxwg3E2RGd22o7hf3-8Apegit8</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Miyoshi, Yurika</creator><creator>Koga, Reiko</creator><creator>Oyama, Tsubasa</creator><creator>Han, Hai</creator><creator>Ueno, Kyoko</creator><creator>Masuyama, Kei</creator><creator>Itoh, Yusuke</creator><creator>Hamase, Kenji</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121001</creationdate><title>HPLC analysis of naturally occurring free d-amino acids in mammals</title><author>Miyoshi, Yurika ; Koga, Reiko ; Oyama, Tsubasa ; Han, Hai ; Ueno, Kyoko ; Masuyama, Kei ; Itoh, Yusuke ; Hamase, Kenji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-16a53c76f72709319ad6d70a77387dc925bfdfb29f030691e3f864fcdc0627973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Amino Acids - chemistry</topic><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - metabolism</topic><topic>Brain - metabolism</topic><topic>Chemistry Techniques, Analytical</topic><topic>Chiral analysis</topic><topic>Chromatography - methods</topic><topic>Chromatography, Gas - methods</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>d-Amino acids</topic><topic>Electrochemistry - methods</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>HPLC</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Metabolomics - methods</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Stereoisomerism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyoshi, Yurika</creatorcontrib><creatorcontrib>Koga, Reiko</creatorcontrib><creatorcontrib>Oyama, Tsubasa</creatorcontrib><creatorcontrib>Han, Hai</creatorcontrib><creatorcontrib>Ueno, Kyoko</creatorcontrib><creatorcontrib>Masuyama, Kei</creatorcontrib><creatorcontrib>Itoh, Yusuke</creatorcontrib><creatorcontrib>Hamase, Kenji</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyoshi, Yurika</au><au>Koga, Reiko</au><au>Oyama, Tsubasa</au><au>Han, Hai</au><au>Ueno, Kyoko</au><au>Masuyama, Kei</au><au>Itoh, Yusuke</au><au>Hamase, Kenji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HPLC analysis of naturally occurring free d-amino acids in mammals</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>69</volume><spage>42</spage><epage>49</epage><pages>42-49</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>d-Amino acids are currently recognized as naturally occurring physiologically active substances and biomarkers in mammals. 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| identifier | ISSN: 0731-7085 |
| ispartof | Journal of pharmaceutical and biomedical analysis, 2012-10, Vol.69, p.42-49 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amino Acids - chemistry Analysis Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Biomarkers - metabolism Brain - metabolism Chemistry Techniques, Analytical Chiral analysis Chromatography - methods Chromatography, Gas - methods Chromatography, High Pressure Liquid - methods d-Amino acids Electrochemistry - methods Fundamental and applied biological sciences. Psychology General pharmacology HPLC Humans Medical sciences Metabolomics - methods Pharmacology. Drug treatments Rats Stereoisomerism |
| title | HPLC analysis of naturally occurring free d-amino acids in mammals |
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