Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance

Scope Inflammasome‐mediated inflammation is a critical regulator of obesity‐induced insulin resistance (IR). We hypothesized that saturated fatty acids (SFA) directly prime the NLRP3 inflammasome via TLR4 concurrent with IR. We focused on dendritic cells (DCs) (CD11c+CD11b+F4/80−), which are recruit...

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Veröffentlicht in:	Molecular nutrition & food research 2012-08, Vol.56 (8), p.1212-1222
Hauptverfasser:	Reynolds, Clare M., McGillicuddy, Fiona C., Harford, Karen A., Finucane, Orla M., Mills, Kingston H. G., Roche, Helen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adipose tissue Adipose Tissue - cytology Adipose Tissue - metabolism Animals Biological and medical sciences Carrier Proteins - metabolism Caspase 1 - metabolism Coculture Techniques Cytokines - metabolism Dendritic cell Dendritic Cells - drug effects Dendritic Cells - metabolism Diet, High-Fat - adverse effects Dietary Fats - pharmacology Fatty Acids - pharmacology Feeding. Feeding behavior Food industries Fundamental and applied biological sciences. Psychology Inflammasome Inflammasomes - drug effects Inflammasomes - metabolism Insulin Resistance - physiology Interleukin-1beta - metabolism Linoleic Acid - pharmacology Male Mice Mice, Inbred C57BL NLR Family, Pyrin Domain-Containing 3 Protein Palmitic acid TLR4 Toll-Like Receptor 4 - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems
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