Genetic polymorphisms and surface expression of CTLA-4 and PD-1 on T cells of silica-exposed workers

Exposure to silica dust has been examined as a possible risk factor for autoimmune diseases, including scleroderma, rheumatoid arthritis and systemic lupus erythematosus. Since CTLA-4 [CD152] and PD-1 [CD279] are important for the maintenance of peripheral tolerance by regulating T cell responsivene...

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Veröffentlicht in:	International journal of hygiene and environmental health 2012-11, Vol.215 (6), p.562-569
Hauptverfasser:	Rocha, Michelle C., Santos, Leonilda M.B., Bagatin, Ericson, Tervaert, Jan W. Cohen, Damoiseaux, Jan G.M.C., Lido, Alessandro V., Longhini, Ana L., Torello, Cristiane O., Queiroz, Mary L.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Air. Soil. Water. Waste. Feeding Autoimmunity Biological and medical sciences Case-Control Studies CD4 Lymphocyte Count CTLA-4 CTLA-4 Antigen - genetics CTLA-4 Antigen - metabolism Environment. Living conditions Female Flow Cytometry Humans Male Medical sciences Middle Aged Miscellaneous Occupational Exposure Occupational medicine PD-1 Polymorphism, Single Nucleotide Polymorphisms Programmed Cell Death 1 Receptor - genetics Programmed Cell Death 1 Receptor - metabolism Public health. Hygiene Public health. Hygiene-occupational medicine Silica Silicon Dioxide - immunology T cells T-Lymphocytes - metabolism Toxicology
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