Genetic polymorphisms and surface expression of CTLA-4 and PD-1 on T cells of silica-exposed workers
Exposure to silica dust has been examined as a possible risk factor for autoimmune diseases, including scleroderma, rheumatoid arthritis and systemic lupus erythematosus. Since CTLA-4 [CD152] and PD-1 [CD279] are important for the maintenance of peripheral tolerance by regulating T cell responsivene...
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| Veröffentlicht in: | International journal of hygiene and environmental health 2012-11, Vol.215 (6), p.562-569 |
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| creator | Rocha, Michelle C. Santos, Leonilda M.B. Bagatin, Ericson Tervaert, Jan W. Cohen Damoiseaux, Jan G.M.C. Lido, Alessandro V. Longhini, Ana L. Torello, Cristiane O. Queiroz, Mary L.S. |
| description | Exposure to silica dust has been examined as a possible risk factor for autoimmune diseases, including scleroderma, rheumatoid arthritis and systemic lupus erythematosus. Since CTLA-4 [CD152] and PD-1 [CD279] are important for the maintenance of peripheral tolerance by regulating T cell responsiveness, we evaluated the expression of these molecules on the surface of CD4 and CD8 T cells, as well as single nucleotide polymorphisms (SNP) in CTLA-4 and PDCD1 genes, of 70 silica-exposed workers and 30 non-exposed, age-, ethnically- and sex-matched controls. Expression of CTLA-4 was significantly (P |
| doi_str_mv | 10.1016/j.ijheh.2011.10.010 |
| format | Article |
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Cohen ; Damoiseaux, Jan G.M.C. ; Lido, Alessandro V. ; Longhini, Ana L. ; Torello, Cristiane O. ; Queiroz, Mary L.S.</creator><creatorcontrib>Rocha, Michelle C. ; Santos, Leonilda M.B. ; Bagatin, Ericson ; Tervaert, Jan W. Cohen ; Damoiseaux, Jan G.M.C. ; Lido, Alessandro V. ; Longhini, Ana L. ; Torello, Cristiane O. ; Queiroz, Mary L.S.</creatorcontrib><description>Exposure to silica dust has been examined as a possible risk factor for autoimmune diseases, including scleroderma, rheumatoid arthritis and systemic lupus erythematosus. Since CTLA-4 [CD152] and PD-1 [CD279] are important for the maintenance of peripheral tolerance by regulating T cell responsiveness, we evaluated the expression of these molecules on the surface of CD4 and CD8 T cells, as well as single nucleotide polymorphisms (SNP) in CTLA-4 and PDCD1 genes, of 70 silica-exposed workers and 30 non-exposed, age-, ethnically- and sex-matched controls. Expression of CTLA-4 was significantly (P<0.05) reduced in CD4 T cells of exposed individuals [median=0.1% and interquartile range, IQR 0.0–0.1% (exposed), median=0.20%, IQR 0.0–0.4% (control)]. Also the expression of PD-1 was significantly (P<0.0001) reduced in both CD4 [median=0.9%, IQR 0.4–2.3% (exposed), median=5.7%, IQR 1.4–13.3% (control)] and CD8 T cells [median=0.9%, IQR 0.3–1.9% (exposed), median=5.0%, IQR 3.4–8.9% (control)]. The study of polymorphisms demonstrated a lower frequency of the A allele in the analysis of the PD1.3 SNP in the exposed group, which might be associated with the lower expression of PD-1 on the surface of CD4 T cells. Our findings provide evidence for the association of silica exposure and the maintenance of self-tolerance, i.e., the susceptibility to autoimmune disorders.</description><identifier>ISSN: 1438-4639</identifier><identifier>EISSN: 1618-131X</identifier><identifier>DOI: 10.1016/j.ijheh.2011.10.010</identifier><identifier>PMID: 22153879</identifier><language>eng</language><publisher>München: Elsevier GmbH</publisher><subject>Aged ; Air. Soil. Water. Waste. Feeding ; Autoimmunity ; Biological and medical sciences ; Case-Control Studies ; CD4 Lymphocyte Count ; CTLA-4 ; CTLA-4 Antigen - genetics ; CTLA-4 Antigen - metabolism ; Environment. Living conditions ; Female ; Flow Cytometry ; Humans ; Male ; Medical sciences ; Middle Aged ; Miscellaneous ; Occupational Exposure ; Occupational medicine ; PD-1 ; Polymorphism, Single Nucleotide ; Polymorphisms ; Programmed Cell Death 1 Receptor - genetics ; Programmed Cell Death 1 Receptor - metabolism ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Silica ; Silicon Dioxide - immunology ; T cells ; T-Lymphocytes - metabolism ; Toxicology</subject><ispartof>International journal of hygiene and environmental health, 2012-11, Vol.215 (6), p.562-569</ispartof><rights>2011 Elsevier GmbH</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier GmbH. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-dc2edd05f186901a9bc3c85b0e9d8f1423d936951bda7a3e3913d523df97a8d13</citedby><cites>FETCH-LOGICAL-c389t-dc2edd05f186901a9bc3c85b0e9d8f1423d936951bda7a3e3913d523df97a8d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1438463911001702$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26299922$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22153879$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rocha, Michelle C.</creatorcontrib><creatorcontrib>Santos, Leonilda M.B.</creatorcontrib><creatorcontrib>Bagatin, Ericson</creatorcontrib><creatorcontrib>Tervaert, Jan W. Cohen</creatorcontrib><creatorcontrib>Damoiseaux, Jan G.M.C.</creatorcontrib><creatorcontrib>Lido, Alessandro V.</creatorcontrib><creatorcontrib>Longhini, Ana L.</creatorcontrib><creatorcontrib>Torello, Cristiane O.</creatorcontrib><creatorcontrib>Queiroz, Mary L.S.</creatorcontrib><title>Genetic polymorphisms and surface expression of CTLA-4 and PD-1 on T cells of silica-exposed workers</title><title>International journal of hygiene and environmental health</title><addtitle>Int J Hyg Environ Health</addtitle><description>Exposure to silica dust has been examined as a possible risk factor for autoimmune diseases, including scleroderma, rheumatoid arthritis and systemic lupus erythematosus. Since CTLA-4 [CD152] and PD-1 [CD279] are important for the maintenance of peripheral tolerance by regulating T cell responsiveness, we evaluated the expression of these molecules on the surface of CD4 and CD8 T cells, as well as single nucleotide polymorphisms (SNP) in CTLA-4 and PDCD1 genes, of 70 silica-exposed workers and 30 non-exposed, age-, ethnically- and sex-matched controls. Expression of CTLA-4 was significantly (P<0.05) reduced in CD4 T cells of exposed individuals [median=0.1% and interquartile range, IQR 0.0–0.1% (exposed), median=0.20%, IQR 0.0–0.4% (control)]. Also the expression of PD-1 was significantly (P<0.0001) reduced in both CD4 [median=0.9%, IQR 0.4–2.3% (exposed), median=5.7%, IQR 1.4–13.3% (control)] and CD8 T cells [median=0.9%, IQR 0.3–1.9% (exposed), median=5.0%, IQR 3.4–8.9% (control)]. The study of polymorphisms demonstrated a lower frequency of the A allele in the analysis of the PD1.3 SNP in the exposed group, which might be associated with the lower expression of PD-1 on the surface of CD4 T cells. Our findings provide evidence for the association of silica exposure and the maintenance of self-tolerance, i.e., the susceptibility to autoimmune disorders.</description><subject>Aged</subject><subject>Air. Soil. Water. Waste. Feeding</subject><subject>Autoimmunity</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>CD4 Lymphocyte Count</subject><subject>CTLA-4</subject><subject>CTLA-4 Antigen - genetics</subject><subject>CTLA-4 Antigen - metabolism</subject><subject>Environment. Living conditions</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Occupational Exposure</subject><subject>Occupational medicine</subject><subject>PD-1</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Polymorphisms</subject><subject>Programmed Cell Death 1 Receptor - genetics</subject><subject>Programmed Cell Death 1 Receptor - metabolism</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Silica</subject><subject>Silicon Dioxide - immunology</subject><subject>T cells</subject><subject>T-Lymphocytes - metabolism</subject><subject>Toxicology</subject><issn>1438-4639</issn><issn>1618-131X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMGO0zAQhi0EYpeFJ0BCviBxSfHYSWofOKwKuyBVgkORuFmuPVFdkjh4WpZ9e5xtgRsnW7-_3zP6GHsJYgEC2rf7RdzvcLeQAqAkCwHiEbuEFnQFCr49Lvda6apulblgz4j2QkgQ2jxlF1JCo_TSXLJwiyMeoudT6u-HlKddpIG4GwOnY-6cR46_poxEMY08dXy1WV9X9QPw5X0FvKQb7rHvaX6l2EfvqlJJhIHfpfwdMz1nTzrXE744n1fs682Hzepjtf58-2l1va680uZQBS8xBNF0oFsjwJmtV143W4Em6A5qqYJRrWlgG9zSKVQGVGhK2pml0wHUFXtz-nfK6ccR6WCHSPNubsR0JAtCqbpZKi0Lqk6oz4koY2enHAeX7wtkZ712bx_02lnvHBa9pfXqPOC4HTD87fzxWYDXZ8CRd32X3egj_eNaaYyR8_h3Jw6Ljp8RsyUfcfQYYkZ_sCHF_y7yG_9JmK0</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Rocha, Michelle C.</creator><creator>Santos, Leonilda M.B.</creator><creator>Bagatin, Ericson</creator><creator>Tervaert, Jan W. 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Cohen ; Damoiseaux, Jan G.M.C. ; Lido, Alessandro V. ; Longhini, Ana L. ; Torello, Cristiane O. ; Queiroz, Mary L.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-dc2edd05f186901a9bc3c85b0e9d8f1423d936951bda7a3e3913d523df97a8d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Air. Soil. Water. Waste. Feeding</topic><topic>Autoimmunity</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>CD4 Lymphocyte Count</topic><topic>CTLA-4</topic><topic>CTLA-4 Antigen - genetics</topic><topic>CTLA-4 Antigen - metabolism</topic><topic>Environment. Living conditions</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Occupational Exposure</topic><topic>Occupational medicine</topic><topic>PD-1</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Polymorphisms</topic><topic>Programmed Cell Death 1 Receptor - genetics</topic><topic>Programmed Cell Death 1 Receptor - metabolism</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Silica</topic><topic>Silicon Dioxide - immunology</topic><topic>T cells</topic><topic>T-Lymphocytes - metabolism</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rocha, Michelle C.</creatorcontrib><creatorcontrib>Santos, Leonilda M.B.</creatorcontrib><creatorcontrib>Bagatin, Ericson</creatorcontrib><creatorcontrib>Tervaert, Jan W. Cohen</creatorcontrib><creatorcontrib>Damoiseaux, Jan G.M.C.</creatorcontrib><creatorcontrib>Lido, Alessandro V.</creatorcontrib><creatorcontrib>Longhini, Ana L.</creatorcontrib><creatorcontrib>Torello, Cristiane O.</creatorcontrib><creatorcontrib>Queiroz, Mary L.S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of hygiene and environmental health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rocha, Michelle C.</au><au>Santos, Leonilda M.B.</au><au>Bagatin, Ericson</au><au>Tervaert, Jan W. Cohen</au><au>Damoiseaux, Jan G.M.C.</au><au>Lido, Alessandro V.</au><au>Longhini, Ana L.</au><au>Torello, Cristiane O.</au><au>Queiroz, Mary L.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic polymorphisms and surface expression of CTLA-4 and PD-1 on T cells of silica-exposed workers</atitle><jtitle>International journal of hygiene and environmental health</jtitle><addtitle>Int J Hyg Environ Health</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>215</volume><issue>6</issue><spage>562</spage><epage>569</epage><pages>562-569</pages><issn>1438-4639</issn><eissn>1618-131X</eissn><abstract>Exposure to silica dust has been examined as a possible risk factor for autoimmune diseases, including scleroderma, rheumatoid arthritis and systemic lupus erythematosus. Since CTLA-4 [CD152] and PD-1 [CD279] are important for the maintenance of peripheral tolerance by regulating T cell responsiveness, we evaluated the expression of these molecules on the surface of CD4 and CD8 T cells, as well as single nucleotide polymorphisms (SNP) in CTLA-4 and PDCD1 genes, of 70 silica-exposed workers and 30 non-exposed, age-, ethnically- and sex-matched controls. Expression of CTLA-4 was significantly (P<0.05) reduced in CD4 T cells of exposed individuals [median=0.1% and interquartile range, IQR 0.0–0.1% (exposed), median=0.20%, IQR 0.0–0.4% (control)]. Also the expression of PD-1 was significantly (P<0.0001) reduced in both CD4 [median=0.9%, IQR 0.4–2.3% (exposed), median=5.7%, IQR 1.4–13.3% (control)] and CD8 T cells [median=0.9%, IQR 0.3–1.9% (exposed), median=5.0%, IQR 3.4–8.9% (control)]. The study of polymorphisms demonstrated a lower frequency of the A allele in the analysis of the PD1.3 SNP in the exposed group, which might be associated with the lower expression of PD-1 on the surface of CD4 T cells. Our findings provide evidence for the association of silica exposure and the maintenance of self-tolerance, i.e., the susceptibility to autoimmune disorders.</abstract><cop>München</cop><pub>Elsevier GmbH</pub><pmid>22153879</pmid><doi>10.1016/j.ijheh.2011.10.010</doi><tpages>8</tpages></addata></record> |
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| subjects | Aged Air. Soil. Water. Waste. Feeding Autoimmunity Biological and medical sciences Case-Control Studies CD4 Lymphocyte Count CTLA-4 CTLA-4 Antigen - genetics CTLA-4 Antigen - metabolism Environment. Living conditions Female Flow Cytometry Humans Male Medical sciences Middle Aged Miscellaneous Occupational Exposure Occupational medicine PD-1 Polymorphism, Single Nucleotide Polymorphisms Programmed Cell Death 1 Receptor - genetics Programmed Cell Death 1 Receptor - metabolism Public health. Hygiene Public health. Hygiene-occupational medicine Silica Silicon Dioxide - immunology T cells T-Lymphocytes - metabolism Toxicology |
| title | Genetic polymorphisms and surface expression of CTLA-4 and PD-1 on T cells of silica-exposed workers |
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