CARDIOPROTECTIVE EFFECT OF l-GLUTAMATE IN OBESE TYPE 2 DIABETIC ZUCKER FATTY RATS

SUMMARY 1 Because diabetic hearts have an increased threshold for cardioprotection by ischaemic preconditioning (IPC), we hypothesized that protection by l‐glutamate during reperfusion is restricted in Type 2 diabetic hearts. Previously, we found that l‐glutamate‐mediated postischaemic cardioprotect...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 2009-09, Vol.36 (9), p.892-898
Hauptverfasser:	Povlsen, JA, Løfgren, B, Rasmussen, LE, Nielsen, JM, Nørregaard, R, Kristiansen, SB, Bøtker, HE, Nielsen, TT
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cardiotonic Agents - pharmacology Diabetes Complications - etiology Diabetes Complications - genetics Diabetes Complications - metabolism Diabetes Complications - pathology Diabetes Complications - physiopathology Diabetes Complications - prevention & control diabetes mellitus Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - etiology Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology Disease Models, Animal Dose-Response Relationship, Drug Excitatory Amino Acid Transporter 1 - genetics Excitatory Amino Acid Transporter 1 - metabolism Excitatory Amino Acid Transporter 3 - genetics Excitatory Amino Acid Transporter 3 - metabolism excitatory amino acid transporters Glutamic Acid - pharmacology Hemodynamics - drug effects ischaemia l-glutamate Male Mitochondria, Heart - drug effects Mitochondria, Heart - metabolism myocardial infarction Myocardial Infarction - etiology Myocardial Infarction - genetics Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardial Infarction - prevention & control Myocardial Reperfusion Injury - etiology Myocardial Reperfusion Injury - genetics Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - physiopathology Myocardial Reperfusion Injury - prevention & control Myocardium - metabolism Myocardium - pathology Obesity - complications Perfusion Polymerase Chain Reaction Rats Rats, Inbred WKY Rats, Zucker reperfusion RNA, Messenger - metabolism Sarcolemma - drug effects Sarcolemma - metabolism Time Factors Ventricular Function, Left - drug effects
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