Nodular Lymphocyte-Predominant Hodgkin Lymphoma: Cytopathologic Correlates on Fine-Needle Aspiration
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), a rare subtype of Hodgkin lymphoma, is an indolent tumor with frequent instances of disease recurrence but a favorable prognosis. To the best of the authors' knowledge, there are only limited descriptions of NLPHL in the cytology literatu...
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| Veröffentlicht in: | Cancer cytopathology 2012-08, Vol.120 (4), p.254-260 |
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| creator | SUBHAWONG, Andrea P ALI, Syed Z TATSAS, Armanda D |
| description | Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), a rare subtype of Hodgkin lymphoma, is an indolent tumor with frequent instances of disease recurrence but a favorable prognosis. To the best of the authors' knowledge, there are only limited descriptions of NLPHL in the cytology literature because it was only formally recognized as a distinct entity in 1994.
In the current study, all cases of NLPHL diagnosed on excisional biopsy (n = 6 cases) at the study institution between 2000 and 2011 that had undergone previous fine-needle aspiration (FNA) were reviewed, with a focus on cytomorphologic features.
Four of 6 cases were termed benign on FNA; however, there was retrospective recognition of characteristic LP cells in all cases. Unlike classical Hodgkin lymphoma, the tumor cells of NLPHL were often found to be mononucleate and presented in a background of small lymphocytes. Other features identified included epithelioid histiocytes and numerous bare atypical nuclei.
Cases of NLPHL are commonly misdiagnosed as benign reactive lymphoid tissue and therefore a careful search using high magnification for LP cells is recommended in the evaluation of lymph node FNAs. |
| doi_str_mv | 10.1002/cncy.21186 |
| format | Article |
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In the current study, all cases of NLPHL diagnosed on excisional biopsy (n = 6 cases) at the study institution between 2000 and 2011 that had undergone previous fine-needle aspiration (FNA) were reviewed, with a focus on cytomorphologic features.
Four of 6 cases were termed benign on FNA; however, there was retrospective recognition of characteristic LP cells in all cases. Unlike classical Hodgkin lymphoma, the tumor cells of NLPHL were often found to be mononucleate and presented in a background of small lymphocytes. Other features identified included epithelioid histiocytes and numerous bare atypical nuclei.
Cases of NLPHL are commonly misdiagnosed as benign reactive lymphoid tissue and therefore a careful search using high magnification for LP cells is recommended in the evaluation of lymph node FNAs.</description><identifier>ISSN: 1934-662X</identifier><identifier>EISSN: 1934-6638</identifier><identifier>DOI: 10.1002/cncy.21186</identifier><identifier>PMID: 22367911</identifier><language>eng</language><publisher>Hoboken, NJ: Wiley</publisher><subject>Adult ; Biological and medical sciences ; Biopsy, Fine-Needle ; Female ; Flow Cytometry ; Follow-Up Studies ; Hematologic and hematopoietic diseases ; Hematology ; Hodgkin Disease - pathology ; Humans ; Immunophenotyping ; Investigative techniques, diagnostic techniques (general aspects) ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymph Nodes - pathology ; Lymphocytes - pathology ; Male ; Medical sciences ; Middle Aged ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Prognosis ; Retrospective Studies</subject><ispartof>Cancer cytopathology, 2012-08, Vol.120 (4), p.254-260</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 American Cancer Society.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c191t-e38defa8339a587fdfdc646750bbbd9ca1f4692a6e799d1901ddd634e4801be83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26259613$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22367911$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SUBHAWONG, Andrea P</creatorcontrib><creatorcontrib>ALI, Syed Z</creatorcontrib><creatorcontrib>TATSAS, Armanda D</creatorcontrib><title>Nodular Lymphocyte-Predominant Hodgkin Lymphoma: Cytopathologic Correlates on Fine-Needle Aspiration</title><title>Cancer cytopathology</title><addtitle>Cancer Cytopathol</addtitle><description>Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), a rare subtype of Hodgkin lymphoma, is an indolent tumor with frequent instances of disease recurrence but a favorable prognosis. To the best of the authors' knowledge, there are only limited descriptions of NLPHL in the cytology literature because it was only formally recognized as a distinct entity in 1994.
In the current study, all cases of NLPHL diagnosed on excisional biopsy (n = 6 cases) at the study institution between 2000 and 2011 that had undergone previous fine-needle aspiration (FNA) were reviewed, with a focus on cytomorphologic features.
Four of 6 cases were termed benign on FNA; however, there was retrospective recognition of characteristic LP cells in all cases. Unlike classical Hodgkin lymphoma, the tumor cells of NLPHL were often found to be mononucleate and presented in a background of small lymphocytes. Other features identified included epithelioid histiocytes and numerous bare atypical nuclei.
Cases of NLPHL are commonly misdiagnosed as benign reactive lymphoid tissue and therefore a careful search using high magnification for LP cells is recommended in the evaluation of lymph node FNAs.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Fine-Needle</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Follow-Up Studies</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Hodgkin Disease - pathology</subject><subject>Humans</subject><subject>Immunophenotyping</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphocytes - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><issn>1934-662X</issn><issn>1934-6638</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0E1LxDAQgOEgiq4fF3-A9CKIUM00bZp4k8UvWNSDgreSJtM12iY16R76713ddT3NwDzM4SXkGOgFUJpdaqfHiwxA8C0yAcnylHMmtjd79rZH9mP8oBREmcEu2csyxksJMCHm0ZtFq0IyG7v-3etxwPQ5oPGddcoNyb0380_r1udOXSXTcfC9Gt596-dWJ1MfArZqwJh4l9xah-kjomkxuY69DWqw3h2SnUa1EY_W84C83t68TO_T2dPdw_R6lmqQMKTIhMFGCcakKkTZmMZonvOyoHVdG6kVNDmXmeJYSmlAUjDGcJZjLijUKNgBOVv97YP_WmAcqs5GjW2rHPpFrIAylhdcsGJJz1dUBx9jwKbqg-1UGJeo-qla_VStfqsu8cn676Lu0GzoX8YlOF0DFbVqm6CctvHf8ayQHBj7Bt4fgas</recordid><startdate>20120825</startdate><enddate>20120825</enddate><creator>SUBHAWONG, Andrea P</creator><creator>ALI, Syed Z</creator><creator>TATSAS, Armanda D</creator><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120825</creationdate><title>Nodular Lymphocyte-Predominant Hodgkin Lymphoma: Cytopathologic Correlates on Fine-Needle Aspiration</title><author>SUBHAWONG, Andrea P ; ALI, Syed Z ; TATSAS, Armanda D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c191t-e38defa8339a587fdfdc646750bbbd9ca1f4692a6e799d1901ddd634e4801be83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Fine-Needle</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Follow-Up Studies</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology</topic><topic>Hodgkin Disease - pathology</topic><topic>Humans</topic><topic>Immunophenotyping</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphocytes - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><toplevel>online_resources</toplevel><creatorcontrib>SUBHAWONG, Andrea P</creatorcontrib><creatorcontrib>ALI, Syed Z</creatorcontrib><creatorcontrib>TATSAS, Armanda D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer cytopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SUBHAWONG, Andrea P</au><au>ALI, Syed Z</au><au>TATSAS, Armanda D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nodular Lymphocyte-Predominant Hodgkin Lymphoma: Cytopathologic Correlates on Fine-Needle Aspiration</atitle><jtitle>Cancer cytopathology</jtitle><addtitle>Cancer Cytopathol</addtitle><date>2012-08-25</date><risdate>2012</risdate><volume>120</volume><issue>4</issue><spage>254</spage><epage>260</epage><pages>254-260</pages><issn>1934-662X</issn><eissn>1934-6638</eissn><abstract>Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), a rare subtype of Hodgkin lymphoma, is an indolent tumor with frequent instances of disease recurrence but a favorable prognosis. To the best of the authors' knowledge, there are only limited descriptions of NLPHL in the cytology literature because it was only formally recognized as a distinct entity in 1994.
In the current study, all cases of NLPHL diagnosed on excisional biopsy (n = 6 cases) at the study institution between 2000 and 2011 that had undergone previous fine-needle aspiration (FNA) were reviewed, with a focus on cytomorphologic features.
Four of 6 cases were termed benign on FNA; however, there was retrospective recognition of characteristic LP cells in all cases. Unlike classical Hodgkin lymphoma, the tumor cells of NLPHL were often found to be mononucleate and presented in a background of small lymphocytes. Other features identified included epithelioid histiocytes and numerous bare atypical nuclei.
Cases of NLPHL are commonly misdiagnosed as benign reactive lymphoid tissue and therefore a careful search using high magnification for LP cells is recommended in the evaluation of lymph node FNAs.</abstract><cop>Hoboken, NJ</cop><pub>Wiley</pub><pmid>22367911</pmid><doi>10.1002/cncy.21186</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Biopsy, Fine-Needle Female Flow Cytometry Follow-Up Studies Hematologic and hematopoietic diseases Hematology Hodgkin Disease - pathology Humans Immunophenotyping Investigative techniques, diagnostic techniques (general aspects) Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymph Nodes - pathology Lymphocytes - pathology Male Medical sciences Middle Aged Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Prognosis Retrospective Studies |
| title | Nodular Lymphocyte-Predominant Hodgkin Lymphoma: Cytopathologic Correlates on Fine-Needle Aspiration |
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