The effect of targeted delivery of anti-TNF-α oligonucleotide into CD169+ macrophages on disease progression in lupus-prone MRL/lpr mice

Abstract Systemic blockade of TNF-α via monoclonal antibodies and soluble receptors has shown considerable effects against several typical autoimmune disorders, but remains unconvincing for the treatment of lupus. Based on our previous study, a CD169+ macrophage-specific therapy using TNF-α antisens...

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Veröffentlicht in:	Biomaterials 2012-10, Vol.33 (30), p.7605-7612
Hauptverfasser:	Huang, Zhen, Zhang, Zhengping, Zha, Yinhe, Liu, Jialin, Jiang, Yucui, Yang, Yang, Shao, Juan, Sun, Xulun, Cai, Xin, Yin, Yuan, Chen, Jiangning, Dong, Lei, Zhang, Junfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Antisense oligonucleotide CD169+ macrophage Cell Proliferation - drug effects Dentistry Disease Progression Drug Carriers Drug delivery Drug Delivery Systems - methods Implants, Experimental Lupus Erythematosus, Systemic - drug therapy Lupus Erythematosus, Systemic - pathology Lymph Nodes - drug effects Lymph Nodes - metabolism Macrophages - drug effects Macrophages - metabolism Macrophages - pathology Mice Mice, Inbred C57BL Mice, Inbred MRL lpr Oligonucleotides, Antisense - pharmacology Oligonucleotides, Antisense - therapeutic use Sepharose Sialic Acid Binding Ig-like Lectin 1 - metabolism Spleen - drug effects Spleen - metabolism Systemic lupus erythematosus Tissue Distribution - drug effects TNF-α Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism
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