Thymosin β4 is a novel potential prognostic marker in gastrointestinal stromal tumors
Thymosin beta‐4 (Tβ4) is a major actin‐sequestering molecule that contributes to cell growth, differentiation, motility, survival, mitosis and angiogenesis. It is overexpressed in certain type of carcinoma and fibrosarcoma cell lines and is associated with metastatic potential. The aim of this study...
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| Veröffentlicht in: | APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2012-09, Vol.120 (9), p.689-698 |
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| container_title | APMIS : acta pathologica, microbiologica et immunologica Scandinavica |
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| creator | Can, Bilge Karagoz, Filiz Yildiz, Levent Yildirim, Arzu Kefeli, Mehmet Gonullu, Guzin Kandemir, Bedri |
| description | Thymosin beta‐4 (Tβ4) is a major actin‐sequestering molecule that contributes to cell growth, differentiation, motility, survival, mitosis and angiogenesis. It is overexpressed in certain type of carcinoma and fibrosarcoma cell lines and is associated with metastatic potential. The aim of this study was to investigate the relationship between Tβ4 expression and clinicopathologic features and VEGF status in gastrointestinal stromal tumors (GISTs). Retrospectively, 60 GISTs were re‐examined and immunohistochemistry for Tβ4 and VEGF was performed. Increased expression of Tβ4 and VEGF was observed in 26 (43.3%) and in 19 (31.6%) of the tumors, respectively. Tβ4 expression was positively correlated with VEGF expression (p |
| doi_str_mv | 10.1111/j.1600-0463.2012.02887.x |
| format | Article |
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It is overexpressed in certain type of carcinoma and fibrosarcoma cell lines and is associated with metastatic potential. The aim of this study was to investigate the relationship between Tβ4 expression and clinicopathologic features and VEGF status in gastrointestinal stromal tumors (GISTs). Retrospectively, 60 GISTs were re‐examined and immunohistochemistry for Tβ4 and VEGF was performed. Increased expression of Tβ4 and VEGF was observed in 26 (43.3%) and in 19 (31.6%) of the tumors, respectively. Tβ4 expression was positively correlated with VEGF expression (p < 0.01). Tβ4 and VEGF expression were significantly associated with tumor size (p = 0.00 and p = 0.02, respectively) and high mitosis (p = 0.03 and p = 0.00, respectively). Although Tβ4 expression was positively associated with pleomorphism (p = 0.01), VEGF expression was positively associated with necrosis (p = 0.03). Tβ4 expression was related with local recurrence and/or metastasis (p = 0.03), but VEGF expression was not (p = 0.12). We firstly demonstrate the presence of Tβ4 protein in GISTs. Our study reveals that increased expression of Tβ4 could be considered as an indicator of aggressive behavior of tumor.</description><identifier>ISSN: 0903-4641</identifier><identifier>EISSN: 1600-0463</identifier><identifier>DOI: 10.1111/j.1600-0463.2012.02887.x</identifier><identifier>PMID: 22882257</identifier><language>eng</language><publisher>Oxford: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Disease-Free Survival ; Female ; Gastrointestinal Neoplasms - metabolism ; Gastrointestinal Neoplasms - pathology ; Gastrointestinal stromal tumor ; Gastrointestinal Stromal Tumors - metabolism ; Gastrointestinal Stromal Tumors - pathology ; Host-tumor relations. Immunology. Biological markers ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Male ; Medical sciences ; Middle Aged ; Retrospective Studies ; Thymosin - metabolism ; thymosin beta-4 ; Tumors ; vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - metabolism</subject><ispartof>APMIS : acta pathologica, microbiologica et immunologica Scandinavica, 2012-09, Vol.120 (9), p.689-698</ispartof><rights>2012 The Authors APMIS © 2012 APMIS</rights><rights>2014 INIST-CNRS</rights><rights>2012 The Authors APMIS © 2012 APMIS.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0463.2012.02887.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0463.2012.02887.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26256190$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22882257$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Can, Bilge</creatorcontrib><creatorcontrib>Karagoz, Filiz</creatorcontrib><creatorcontrib>Yildiz, Levent</creatorcontrib><creatorcontrib>Yildirim, Arzu</creatorcontrib><creatorcontrib>Kefeli, Mehmet</creatorcontrib><creatorcontrib>Gonullu, Guzin</creatorcontrib><creatorcontrib>Kandemir, Bedri</creatorcontrib><title>Thymosin β4 is a novel potential prognostic marker in gastrointestinal stromal tumors</title><title>APMIS : acta pathologica, microbiologica et immunologica Scandinavica</title><addtitle>APMIS</addtitle><description>Thymosin beta‐4 (Tβ4) is a major actin‐sequestering molecule that contributes to cell growth, differentiation, motility, survival, mitosis and angiogenesis. It is overexpressed in certain type of carcinoma and fibrosarcoma cell lines and is associated with metastatic potential. The aim of this study was to investigate the relationship between Tβ4 expression and clinicopathologic features and VEGF status in gastrointestinal stromal tumors (GISTs). Retrospectively, 60 GISTs were re‐examined and immunohistochemistry for Tβ4 and VEGF was performed. Increased expression of Tβ4 and VEGF was observed in 26 (43.3%) and in 19 (31.6%) of the tumors, respectively. Tβ4 expression was positively correlated with VEGF expression (p < 0.01). Tβ4 and VEGF expression were significantly associated with tumor size (p = 0.00 and p = 0.02, respectively) and high mitosis (p = 0.03 and p = 0.00, respectively). Although Tβ4 expression was positively associated with pleomorphism (p = 0.01), VEGF expression was positively associated with necrosis (p = 0.03). Tβ4 expression was related with local recurrence and/or metastasis (p = 0.03), but VEGF expression was not (p = 0.12). We firstly demonstrate the presence of Tβ4 protein in GISTs. Our study reveals that increased expression of Tβ4 could be considered as an indicator of aggressive behavior of tumor.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Gastrointestinal Neoplasms - metabolism</subject><subject>Gastrointestinal Neoplasms - pathology</subject><subject>Gastrointestinal stromal tumor</subject><subject>Gastrointestinal Stromal Tumors - metabolism</subject><subject>Gastrointestinal Stromal Tumors - pathology</subject><subject>Host-tumor relations. Immunology. Biological markers</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Thymosin - metabolism</subject><subject>thymosin beta-4</subject><subject>Tumors</subject><subject>vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><issn>0903-4641</issn><issn>1600-0463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkclOwzAQhi0EoqXwCigXJC4JXhLbOXBAiE2U5VCWm-U6DrhkKXEK7WvxIDwTE1qKLzPW_81oZn6EAoIjAu9oEhGOcYhjziKKCY0wlVJE8w3UXwubqI9TzMKYx6SHdryfYCAlF9uoRwGnNBF99Dh6XZS1d1Xw_RUHzgc6qOoPWwTTurVV6zRkTf1S1b51Jih182abAOgX7dumdlVrQaiA6r4lxHZW1o3fRVu5LrzdW8UBejg_G51ehsO7i6vTk2HoaCpFSAwlOLGEZDLLGMvyVJsxTTIS55xYEY9zxlMhKZOSkYxiaxIjx0YYkxKZwZIDdLjsC0O-z2AWVTpvbFHoytYzrwhmLE4SThig-yt0Ni5tpqaNg3UW6u8WABysAO2NLvJGV8b5f45T6AMXHaDjJffpCrtY6wSrzhs1UZ0FqrNAdd6oX2_UXJ3c33QZ1IfLeudbO1_Xw2kVF0wk6un2QqXy-llwdq6G7AdibZG8</recordid><startdate>201209</startdate><enddate>201209</enddate><creator>Can, Bilge</creator><creator>Karagoz, Filiz</creator><creator>Yildiz, Levent</creator><creator>Yildirim, Arzu</creator><creator>Kefeli, Mehmet</creator><creator>Gonullu, Guzin</creator><creator>Kandemir, Bedri</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201209</creationdate><title>Thymosin β4 is a novel potential prognostic marker in gastrointestinal stromal tumors</title><author>Can, Bilge ; Karagoz, Filiz ; Yildiz, Levent ; Yildirim, Arzu ; Kefeli, Mehmet ; Gonullu, Guzin ; Kandemir, Bedri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i2987-1c2105e11d8dd33df9acb25d14f61e74bf36978238831d20ec5c8bc7cc918d463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Gastrointestinal Neoplasms - metabolism</topic><topic>Gastrointestinal Neoplasms - pathology</topic><topic>Gastrointestinal stromal tumor</topic><topic>Gastrointestinal Stromal Tumors - metabolism</topic><topic>Gastrointestinal Stromal Tumors - pathology</topic><topic>Host-tumor relations. Immunology. Biological markers</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Thymosin - metabolism</topic><topic>thymosin beta-4</topic><topic>Tumors</topic><topic>vascular endothelial growth factor</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Can, Bilge</creatorcontrib><creatorcontrib>Karagoz, Filiz</creatorcontrib><creatorcontrib>Yildiz, Levent</creatorcontrib><creatorcontrib>Yildirim, Arzu</creatorcontrib><creatorcontrib>Kefeli, Mehmet</creatorcontrib><creatorcontrib>Gonullu, Guzin</creatorcontrib><creatorcontrib>Kandemir, Bedri</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>APMIS : acta pathologica, microbiologica et immunologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Can, Bilge</au><au>Karagoz, Filiz</au><au>Yildiz, Levent</au><au>Yildirim, Arzu</au><au>Kefeli, Mehmet</au><au>Gonullu, Guzin</au><au>Kandemir, Bedri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thymosin β4 is a novel potential prognostic marker in gastrointestinal stromal tumors</atitle><jtitle>APMIS : acta pathologica, microbiologica et immunologica Scandinavica</jtitle><addtitle>APMIS</addtitle><date>2012-09</date><risdate>2012</risdate><volume>120</volume><issue>9</issue><spage>689</spage><epage>698</epage><pages>689-698</pages><issn>0903-4641</issn><eissn>1600-0463</eissn><abstract>Thymosin beta‐4 (Tβ4) is a major actin‐sequestering molecule that contributes to cell growth, differentiation, motility, survival, mitosis and angiogenesis. It is overexpressed in certain type of carcinoma and fibrosarcoma cell lines and is associated with metastatic potential. The aim of this study was to investigate the relationship between Tβ4 expression and clinicopathologic features and VEGF status in gastrointestinal stromal tumors (GISTs). Retrospectively, 60 GISTs were re‐examined and immunohistochemistry for Tβ4 and VEGF was performed. Increased expression of Tβ4 and VEGF was observed in 26 (43.3%) and in 19 (31.6%) of the tumors, respectively. Tβ4 expression was positively correlated with VEGF expression (p < 0.01). Tβ4 and VEGF expression were significantly associated with tumor size (p = 0.00 and p = 0.02, respectively) and high mitosis (p = 0.03 and p = 0.00, respectively). Although Tβ4 expression was positively associated with pleomorphism (p = 0.01), VEGF expression was positively associated with necrosis (p = 0.03). Tβ4 expression was related with local recurrence and/or metastasis (p = 0.03), but VEGF expression was not (p = 0.12). We firstly demonstrate the presence of Tβ4 protein in GISTs. Our study reveals that increased expression of Tβ4 could be considered as an indicator of aggressive behavior of tumor.</abstract><cop>Oxford</cop><pub>Blackwell Publishing Ltd</pub><pmid>22882257</pmid><doi>10.1111/j.1600-0463.2012.02887.x</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - metabolism Disease-Free Survival Female Gastrointestinal Neoplasms - metabolism Gastrointestinal Neoplasms - pathology Gastrointestinal stromal tumor Gastrointestinal Stromal Tumors - metabolism Gastrointestinal Stromal Tumors - pathology Host-tumor relations. Immunology. Biological markers Humans Immunohistochemistry Kaplan-Meier Estimate Male Medical sciences Middle Aged Retrospective Studies Thymosin - metabolism thymosin beta-4 Tumors vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism |
| title | Thymosin β4 is a novel potential prognostic marker in gastrointestinal stromal tumors |
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