Heterobifunctional Poly(ethylene glycol) Derivatives for the Surface Modification of Gold Nanoparticles Toward Bone Mineral Targeting
Heterobifunctional poly(ethylene glycol)s can be used for many biomedical applications ranging from solubility enhancement of hardly soluble compounds to surface modification of medical devices. In order to modify gold nanoparticles as model particles for drug targeting applications, PEG derivatives...
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| Veröffentlicht in: | Macromolecular bioscience 2012-08, Vol.12 (8), p.1124-1136 |
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| creator | Zayed, Gamal M. S. Tessmar, Joerg K. V. |
| description | Heterobifunctional poly(ethylene glycol)s can be used for many biomedical applications ranging from solubility enhancement of hardly soluble compounds to surface modification of medical devices. In order to modify gold nanoparticles as model particles for drug targeting applications, PEG derivatives are synthesized that possess a high affinity for gold surfaces, namely a thioalkyl function, known to form stable monolayers on gold. Additionally a bisphosphonate function is introduced in the PEG molecule to allow targeting of hydroxyapatite rich tissues, like bone. Gold nanoparticles are modified using the synthesized bifunctional PEG and investigated for their stability in biological fluids and their ability to bind to hydroxyapatite granules in these fluids.
Functional PEG derivatives are very useful for the modification of surfaces for biomedical applications. The synthesis and application of bifunctional polymers is described that are suited to modify gold nanoparticles for bone mineral targeting. The obtained particles are stable in protein and salt containing solutions and show good binding strength to bone mineral. |
| doi_str_mv | 10.1002/mabi.201200046 |
| format | Article |
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Functional PEG derivatives are very useful for the modification of surfaces for biomedical applications. The synthesis and application of bifunctional polymers is described that are suited to modify gold nanoparticles for bone mineral targeting. The obtained particles are stable in protein and salt containing solutions and show good binding strength to bone mineral.</description><identifier>ISSN: 1616-5187</identifier><identifier>EISSN: 1616-5195</identifier><identifier>DOI: 10.1002/mabi.201200046</identifier><identifier>PMID: 22807219</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Applied sciences ; Biological and medical sciences ; Biomimetic Materials - chemistry ; bisphosphonate ; Bone and Bones ; Bone Substitutes ; bone targeting ; Calcification, Physiologic ; Chemical modifications ; Chemical reactions and properties ; Chromatography, High Pressure Liquid ; Colloids ; Diphosphonates - chemistry ; Drug Carriers - chemical synthesis ; Durapatite - chemistry ; Exact sciences and technology ; functionalization of polymers ; General pharmacology ; Gold - chemistry ; Humans ; Magnetic Resonance Spectroscopy ; Medical sciences ; Metal Nanoparticles - chemistry ; Metal Nanoparticles - ultrastructure ; Microscopy, Electron, Transmission ; nanoparticles ; Organic polymers ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Physicochemistry of polymers ; poly(ethylene glycol) ; Polyethylene Glycols - chemistry ; Sulfhydryl Reagents - chemistry</subject><ispartof>Macromolecular bioscience, 2012-08, Vol.12 (8), p.1124-1136</ispartof><rights>Copyright © 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4136-abbda0639356e0a82e9dc59cd5a5ee6b75b4e5d39cc73c7a2be6eccf792b2d93</citedby><cites>FETCH-LOGICAL-c4136-abbda0639356e0a82e9dc59cd5a5ee6b75b4e5d39cc73c7a2be6eccf792b2d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmabi.201200046$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmabi.201200046$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26225477$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22807219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zayed, Gamal M. S.</creatorcontrib><creatorcontrib>Tessmar, Joerg K. V.</creatorcontrib><title>Heterobifunctional Poly(ethylene glycol) Derivatives for the Surface Modification of Gold Nanoparticles Toward Bone Mineral Targeting</title><title>Macromolecular bioscience</title><addtitle>Macromol. Biosci</addtitle><description>Heterobifunctional poly(ethylene glycol)s can be used for many biomedical applications ranging from solubility enhancement of hardly soluble compounds to surface modification of medical devices. In order to modify gold nanoparticles as model particles for drug targeting applications, PEG derivatives are synthesized that possess a high affinity for gold surfaces, namely a thioalkyl function, known to form stable monolayers on gold. Additionally a bisphosphonate function is introduced in the PEG molecule to allow targeting of hydroxyapatite rich tissues, like bone. Gold nanoparticles are modified using the synthesized bifunctional PEG and investigated for their stability in biological fluids and their ability to bind to hydroxyapatite granules in these fluids.
Functional PEG derivatives are very useful for the modification of surfaces for biomedical applications. The synthesis and application of bifunctional polymers is described that are suited to modify gold nanoparticles for bone mineral targeting. The obtained particles are stable in protein and salt containing solutions and show good binding strength to bone mineral.</description><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Biomimetic Materials - chemistry</subject><subject>bisphosphonate</subject><subject>Bone and Bones</subject><subject>Bone Substitutes</subject><subject>bone targeting</subject><subject>Calcification, Physiologic</subject><subject>Chemical modifications</subject><subject>Chemical reactions and properties</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Colloids</subject><subject>Diphosphonates - chemistry</subject><subject>Drug Carriers - chemical synthesis</subject><subject>Durapatite - chemistry</subject><subject>Exact sciences and technology</subject><subject>functionalization of polymers</subject><subject>General pharmacology</subject><subject>Gold - chemistry</subject><subject>Humans</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Metal Nanoparticles - ultrastructure</subject><subject>Microscopy, Electron, Transmission</subject><subject>nanoparticles</subject><subject>Organic polymers</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicochemistry of polymers</subject><subject>poly(ethylene glycol)</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Sulfhydryl Reagents - chemistry</subject><issn>1616-5187</issn><issn>1616-5195</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9v0zAYhiMEYlvhyhH5grQdUvwjjpPjNqAbrAVEJSQu1hfnS2dw485ONvIH8H-TqqVw4-Tv8Dzva71J8oLRKaOUv15DZaecMk4pzfJHyTHLWZ5KVsrHh7tQR8lJjN8pZaoo-dPkiPOCKs7K4-TXFXYYfGWbvjWd9S048sm74RS728Fhi2TlBuPdGXmDwd5DZ-8xksYH0t0i-dKHBgySua9tYw1sA4hvyMy7miyg9RsInTVuVJb-AUJNLvwYObcthrFoCWGFnW1Xz5InDbiIz_fvJFm-e7u8vEpvPs6uL89vUpMxkadQVTXQXJRC5kih4FjWRpamliAR80rJKkNZi9IYJYwCXmGOxjSq5BWvSzFJTnexm-DveoydXtto0Dlo0fdRMypEJjMxlk2S6Q41wccYsNGbYNcQhhHS2-X1dnl9WH4UXu6z-2qN9QH_M_UIvNoDEA24JkBrbPzL5ZzLTKmRK3fcg3U4_KdWz88vrv_9RLpzbezw58GF8EPnSiipvy5mevHhc6HYe6q_id_K1674</recordid><startdate>201208</startdate><enddate>201208</enddate><creator>Zayed, Gamal M. S.</creator><creator>Tessmar, Joerg K. V.</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley-VCH</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201208</creationdate><title>Heterobifunctional Poly(ethylene glycol) Derivatives for the Surface Modification of Gold Nanoparticles Toward Bone Mineral Targeting</title><author>Zayed, Gamal M. S. ; Tessmar, Joerg K. V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4136-abbda0639356e0a82e9dc59cd5a5ee6b75b4e5d39cc73c7a2be6eccf792b2d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Applied sciences</topic><topic>Biological and medical sciences</topic><topic>Biomimetic Materials - chemistry</topic><topic>bisphosphonate</topic><topic>Bone and Bones</topic><topic>Bone Substitutes</topic><topic>bone targeting</topic><topic>Calcification, Physiologic</topic><topic>Chemical modifications</topic><topic>Chemical reactions and properties</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Colloids</topic><topic>Diphosphonates - chemistry</topic><topic>Drug Carriers - chemical synthesis</topic><topic>Durapatite - chemistry</topic><topic>Exact sciences and technology</topic><topic>functionalization of polymers</topic><topic>General pharmacology</topic><topic>Gold - chemistry</topic><topic>Humans</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Metal Nanoparticles - ultrastructure</topic><topic>Microscopy, Electron, Transmission</topic><topic>nanoparticles</topic><topic>Organic polymers</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Physicochemistry of polymers</topic><topic>poly(ethylene glycol)</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Sulfhydryl Reagents - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zayed, Gamal M. S.</creatorcontrib><creatorcontrib>Tessmar, Joerg K. V.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Macromolecular bioscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zayed, Gamal M. S.</au><au>Tessmar, Joerg K. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heterobifunctional Poly(ethylene glycol) Derivatives for the Surface Modification of Gold Nanoparticles Toward Bone Mineral Targeting</atitle><jtitle>Macromolecular bioscience</jtitle><addtitle>Macromol. Biosci</addtitle><date>2012-08</date><risdate>2012</risdate><volume>12</volume><issue>8</issue><spage>1124</spage><epage>1136</epage><pages>1124-1136</pages><issn>1616-5187</issn><eissn>1616-5195</eissn><abstract>Heterobifunctional poly(ethylene glycol)s can be used for many biomedical applications ranging from solubility enhancement of hardly soluble compounds to surface modification of medical devices. In order to modify gold nanoparticles as model particles for drug targeting applications, PEG derivatives are synthesized that possess a high affinity for gold surfaces, namely a thioalkyl function, known to form stable monolayers on gold. Additionally a bisphosphonate function is introduced in the PEG molecule to allow targeting of hydroxyapatite rich tissues, like bone. Gold nanoparticles are modified using the synthesized bifunctional PEG and investigated for their stability in biological fluids and their ability to bind to hydroxyapatite granules in these fluids.
Functional PEG derivatives are very useful for the modification of surfaces for biomedical applications. The synthesis and application of bifunctional polymers is described that are suited to modify gold nanoparticles for bone mineral targeting. The obtained particles are stable in protein and salt containing solutions and show good binding strength to bone mineral.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><pmid>22807219</pmid><doi>10.1002/mabi.201200046</doi><tpages>13</tpages></addata></record> |
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| subjects | Applied sciences Biological and medical sciences Biomimetic Materials - chemistry bisphosphonate Bone and Bones Bone Substitutes bone targeting Calcification, Physiologic Chemical modifications Chemical reactions and properties Chromatography, High Pressure Liquid Colloids Diphosphonates - chemistry Drug Carriers - chemical synthesis Durapatite - chemistry Exact sciences and technology functionalization of polymers General pharmacology Gold - chemistry Humans Magnetic Resonance Spectroscopy Medical sciences Metal Nanoparticles - chemistry Metal Nanoparticles - ultrastructure Microscopy, Electron, Transmission nanoparticles Organic polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers poly(ethylene glycol) Polyethylene Glycols - chemistry Sulfhydryl Reagents - chemistry |
| title | Heterobifunctional Poly(ethylene glycol) Derivatives for the Surface Modification of Gold Nanoparticles Toward Bone Mineral Targeting |
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