Staging laparoscopy using ALA-mediated photodynamic diagnosis improves the detection of peritoneal metastases in advanced gastric cancer
Background This study evaluated the usefulness of photodynamic diagnosis (PDD) using oral 5‐aminolevulinic acid (ALA) for the detection of peritoneal metastases in advanced gastric cancer. Method First, the numbers of peritoneal metastatic nodules that were visible under conventional white light (WL...
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| Veröffentlicht in: | Journal of surgical oncology 2012-09, Vol.106 (3), p.294-298 |
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| creator | Kishi, Kentaro Fujiwara, Yoshiyuki Yano, Masahiko Inoue, Masahiro Miyashiro, Isao Motoori, Masaaki Shingai, Tatsushi Gotoh, Kunihito Takahashi, Hidenori Noura, Shingo Yamada, Terumasa Ohue, Masayuki Ohigashi, Hiroaki Ishikawa, Osamu |
| description | Background
This study evaluated the usefulness of photodynamic diagnosis (PDD) using oral 5‐aminolevulinic acid (ALA) for the detection of peritoneal metastases in advanced gastric cancer.
Method
First, the numbers of peritoneal metastatic nodules that were visible under conventional white light (WL) and ALA‐induced fluorescence (ALA‐F) were quantified in a mouse model of peritoneal metastasis to compare the tumor detection rate. Next, staging laparoscopy (SL) using ALA‐PDD was performed in 13 advanced gastric cancer patients with serosa‐invading tumors, and the detection sensitivity of ALA‐PDD was compared to the observations using WL.
Results
The tumor detection rate using ALA‐F was significantly higher than the detection rate using WL (72% vs. 39%, respectively, P |
| doi_str_mv | 10.1002/jso.23075 |
| format | Article |
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This study evaluated the usefulness of photodynamic diagnosis (PDD) using oral 5‐aminolevulinic acid (ALA) for the detection of peritoneal metastases in advanced gastric cancer.
Method
First, the numbers of peritoneal metastatic nodules that were visible under conventional white light (WL) and ALA‐induced fluorescence (ALA‐F) were quantified in a mouse model of peritoneal metastasis to compare the tumor detection rate. Next, staging laparoscopy (SL) using ALA‐PDD was performed in 13 advanced gastric cancer patients with serosa‐invading tumors, and the detection sensitivity of ALA‐PDD was compared to the observations using WL.
Results
The tumor detection rate using ALA‐F was significantly higher than the detection rate using WL (72% vs. 39%, respectively, P < 0.0001). Peritoneal metastases were detected in five patients using SL with ALA‐PDD, and liver metastases were detected in one patient. These metastases were confirmed using histological examination. Three metastatic lesions that were invisible under WL were detected under ALA‐F.
Conclusion
This study demonstrated that SL with ALA‐PDD improved the detection sensitivity for peritoneal metastases. ALA‐PDD may be an important technique for the preoperative staging of advanced gastric cancer, and ALA‐PDD will provide useful information for the selection of therapeutic modality. J. Surg. Oncol. 2012; 106:294–298. © 2012 Wiley Periodicals, Inc.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.23075</identifier><identifier>PMID: 22389064</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>5-aminolevulinic acid (ALA) ; Aged ; Aged, 80 and over ; Aminolevulinic Acid ; Animals ; Disease Models, Animal ; Female ; Fluorescence ; gastric cancer ; Humans ; Laparoscopy ; Light ; Liver Neoplasms - diagnosis ; Liver Neoplasms - secondary ; Male ; Mice ; Mice, Inbred BALB C ; micrometastasis ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging - methods ; peritoneal metastasis ; Peritoneal Neoplasms - diagnosis ; Peritoneal Neoplasms - secondary ; photodynamic diagnosis (PDD) ; Photosensitizing Agents ; Serous Membrane - pathology ; Stomach Neoplasms - pathology</subject><ispartof>Journal of surgical oncology, 2012-09, Vol.106 (3), p.294-298</ispartof><rights>Copyright © 2012 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4295-2613dc63a9600ae8ef785cef85cfdf7031c050aa00b80726b936cb5a8cfb8ebb3</citedby><cites>FETCH-LOGICAL-c4295-2613dc63a9600ae8ef785cef85cfdf7031c050aa00b80726b936cb5a8cfb8ebb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.23075$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.23075$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22389064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kishi, Kentaro</creatorcontrib><creatorcontrib>Fujiwara, Yoshiyuki</creatorcontrib><creatorcontrib>Yano, Masahiko</creatorcontrib><creatorcontrib>Inoue, Masahiro</creatorcontrib><creatorcontrib>Miyashiro, Isao</creatorcontrib><creatorcontrib>Motoori, Masaaki</creatorcontrib><creatorcontrib>Shingai, Tatsushi</creatorcontrib><creatorcontrib>Gotoh, Kunihito</creatorcontrib><creatorcontrib>Takahashi, Hidenori</creatorcontrib><creatorcontrib>Noura, Shingo</creatorcontrib><creatorcontrib>Yamada, Terumasa</creatorcontrib><creatorcontrib>Ohue, Masayuki</creatorcontrib><creatorcontrib>Ohigashi, Hiroaki</creatorcontrib><creatorcontrib>Ishikawa, Osamu</creatorcontrib><title>Staging laparoscopy using ALA-mediated photodynamic diagnosis improves the detection of peritoneal metastases in advanced gastric cancer</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Background
This study evaluated the usefulness of photodynamic diagnosis (PDD) using oral 5‐aminolevulinic acid (ALA) for the detection of peritoneal metastases in advanced gastric cancer.
Method
First, the numbers of peritoneal metastatic nodules that were visible under conventional white light (WL) and ALA‐induced fluorescence (ALA‐F) were quantified in a mouse model of peritoneal metastasis to compare the tumor detection rate. Next, staging laparoscopy (SL) using ALA‐PDD was performed in 13 advanced gastric cancer patients with serosa‐invading tumors, and the detection sensitivity of ALA‐PDD was compared to the observations using WL.
Results
The tumor detection rate using ALA‐F was significantly higher than the detection rate using WL (72% vs. 39%, respectively, P < 0.0001). Peritoneal metastases were detected in five patients using SL with ALA‐PDD, and liver metastases were detected in one patient. These metastases were confirmed using histological examination. Three metastatic lesions that were invisible under WL were detected under ALA‐F.
Conclusion
This study demonstrated that SL with ALA‐PDD improved the detection sensitivity for peritoneal metastases. ALA‐PDD may be an important technique for the preoperative staging of advanced gastric cancer, and ALA‐PDD will provide useful information for the selection of therapeutic modality. J. Surg. Oncol. 2012; 106:294–298. © 2012 Wiley Periodicals, Inc.</description><subject>5-aminolevulinic acid (ALA)</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aminolevulinic Acid</subject><subject>Animals</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Fluorescence</subject><subject>gastric cancer</subject><subject>Humans</subject><subject>Laparoscopy</subject><subject>Light</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver Neoplasms - secondary</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>micrometastasis</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging - methods</subject><subject>peritoneal metastasis</subject><subject>Peritoneal Neoplasms - diagnosis</subject><subject>Peritoneal Neoplasms - secondary</subject><subject>photodynamic diagnosis (PDD)</subject><subject>Photosensitizing Agents</subject><subject>Serous Membrane - pathology</subject><subject>Stomach Neoplasms - pathology</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1u1DAURi0EokNhwQsgL2GR9sbOn5dDBYUytItCYWfdODdTlyQOtqcwb8Bj42Ha7pAsW_587ifrMPYyh6McQBzfBHckJNTlI7bIQVWZAtU8Zov0JrKiVnDAnoVwAwBKVcVTdiCEbBRUxYL9uYy4ttOaDzijd8G4ecs3YZcsV8tspM5ipI7P1y66bjvhaA1P2XpywQZux9m7Wwo8XhPvKJKJ1k3c9Xwmb6ObCAc-UsSQVsLsxLG7xcmkynUKfWozu6t_zp70OAR6cXcesq_v3305-ZCtLk4_nixXmSmEKjNR5bIzlURVASA11NdNaahPW9_1NcjcQAmIAG0DtahaJSvTltiYvm2obeUhe73vTR__uaEQ9WiDoWHAidwm6BykLEpZiDKhb_aoSWKCp17P3o7otwnSO_E6idf_xCf21V3tpk3SHsh70wk43gO_7EDb_zfps8uL-8psP2FDpN8PE-h_6KqWifx2fqrPP729OvuurvRn-Rf1OZ_z</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Kishi, Kentaro</creator><creator>Fujiwara, Yoshiyuki</creator><creator>Yano, Masahiko</creator><creator>Inoue, Masahiro</creator><creator>Miyashiro, Isao</creator><creator>Motoori, Masaaki</creator><creator>Shingai, Tatsushi</creator><creator>Gotoh, Kunihito</creator><creator>Takahashi, Hidenori</creator><creator>Noura, Shingo</creator><creator>Yamada, Terumasa</creator><creator>Ohue, Masayuki</creator><creator>Ohigashi, Hiroaki</creator><creator>Ishikawa, Osamu</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120901</creationdate><title>Staging laparoscopy using ALA-mediated photodynamic diagnosis improves the detection of peritoneal metastases in advanced gastric cancer</title><author>Kishi, Kentaro ; Fujiwara, Yoshiyuki ; Yano, Masahiko ; Inoue, Masahiro ; Miyashiro, Isao ; Motoori, Masaaki ; Shingai, Tatsushi ; Gotoh, Kunihito ; Takahashi, Hidenori ; Noura, Shingo ; Yamada, Terumasa ; Ohue, Masayuki ; Ohigashi, Hiroaki ; Ishikawa, Osamu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4295-2613dc63a9600ae8ef785cef85cfdf7031c050aa00b80726b936cb5a8cfb8ebb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>5-aminolevulinic acid (ALA)</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aminolevulinic Acid</topic><topic>Animals</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Fluorescence</topic><topic>gastric cancer</topic><topic>Humans</topic><topic>Laparoscopy</topic><topic>Light</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Liver Neoplasms - secondary</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>micrometastasis</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging - methods</topic><topic>peritoneal metastasis</topic><topic>Peritoneal Neoplasms - diagnosis</topic><topic>Peritoneal Neoplasms - secondary</topic><topic>photodynamic diagnosis (PDD)</topic><topic>Photosensitizing Agents</topic><topic>Serous Membrane - pathology</topic><topic>Stomach Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kishi, Kentaro</creatorcontrib><creatorcontrib>Fujiwara, Yoshiyuki</creatorcontrib><creatorcontrib>Yano, Masahiko</creatorcontrib><creatorcontrib>Inoue, Masahiro</creatorcontrib><creatorcontrib>Miyashiro, Isao</creatorcontrib><creatorcontrib>Motoori, Masaaki</creatorcontrib><creatorcontrib>Shingai, Tatsushi</creatorcontrib><creatorcontrib>Gotoh, Kunihito</creatorcontrib><creatorcontrib>Takahashi, Hidenori</creatorcontrib><creatorcontrib>Noura, Shingo</creatorcontrib><creatorcontrib>Yamada, Terumasa</creatorcontrib><creatorcontrib>Ohue, Masayuki</creatorcontrib><creatorcontrib>Ohigashi, Hiroaki</creatorcontrib><creatorcontrib>Ishikawa, Osamu</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kishi, Kentaro</au><au>Fujiwara, Yoshiyuki</au><au>Yano, Masahiko</au><au>Inoue, Masahiro</au><au>Miyashiro, Isao</au><au>Motoori, Masaaki</au><au>Shingai, Tatsushi</au><au>Gotoh, Kunihito</au><au>Takahashi, Hidenori</au><au>Noura, Shingo</au><au>Yamada, Terumasa</au><au>Ohue, Masayuki</au><au>Ohigashi, Hiroaki</au><au>Ishikawa, Osamu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Staging laparoscopy using ALA-mediated photodynamic diagnosis improves the detection of peritoneal metastases in advanced gastric cancer</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>106</volume><issue>3</issue><spage>294</spage><epage>298</epage><pages>294-298</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Background
This study evaluated the usefulness of photodynamic diagnosis (PDD) using oral 5‐aminolevulinic acid (ALA) for the detection of peritoneal metastases in advanced gastric cancer.
Method
First, the numbers of peritoneal metastatic nodules that were visible under conventional white light (WL) and ALA‐induced fluorescence (ALA‐F) were quantified in a mouse model of peritoneal metastasis to compare the tumor detection rate. Next, staging laparoscopy (SL) using ALA‐PDD was performed in 13 advanced gastric cancer patients with serosa‐invading tumors, and the detection sensitivity of ALA‐PDD was compared to the observations using WL.
Results
The tumor detection rate using ALA‐F was significantly higher than the detection rate using WL (72% vs. 39%, respectively, P < 0.0001). Peritoneal metastases were detected in five patients using SL with ALA‐PDD, and liver metastases were detected in one patient. These metastases were confirmed using histological examination. Three metastatic lesions that were invisible under WL were detected under ALA‐F.
Conclusion
This study demonstrated that SL with ALA‐PDD improved the detection sensitivity for peritoneal metastases. ALA‐PDD may be an important technique for the preoperative staging of advanced gastric cancer, and ALA‐PDD will provide useful information for the selection of therapeutic modality. J. Surg. Oncol. 2012; 106:294–298. © 2012 Wiley Periodicals, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>22389064</pmid><doi>10.1002/jso.23075</doi><tpages>5</tpages></addata></record> |
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| subjects | 5-aminolevulinic acid (ALA) Aged Aged, 80 and over Aminolevulinic Acid Animals Disease Models, Animal Female Fluorescence gastric cancer Humans Laparoscopy Light Liver Neoplasms - diagnosis Liver Neoplasms - secondary Male Mice Mice, Inbred BALB C micrometastasis Middle Aged Neoplasm Invasiveness Neoplasm Staging - methods peritoneal metastasis Peritoneal Neoplasms - diagnosis Peritoneal Neoplasms - secondary photodynamic diagnosis (PDD) Photosensitizing Agents Serous Membrane - pathology Stomach Neoplasms - pathology |
| title | Staging laparoscopy using ALA-mediated photodynamic diagnosis improves the detection of peritoneal metastases in advanced gastric cancer |
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