IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

When unfolded proteins accumulate to irremediably high levels within the endoplasmic reticulum (ER), intracellular signaling pathways called the unfolded protein response (UPR) become hyperactivated to cause programmed cell death. We discovered that thioredoxin-interacting protein (TXNIP) is a criti...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell metabolism 2012-08, Vol.16 (2), p.250-264
Hauptverfasser:	Lerner, Alana G., Upton, John-Paul, Praveen, P.V.K., Ghosh, Rajarshi, Nakagawa, Yoshimi, Igbaria, Aeid, Shen, Sarah, Nguyen, Vinh, Backes, Bradley J., Heiman, Myriam, Heintz, Nathaniel, Greengard, Paul, Hui, Simon, Tang, Qizhi, Trusina, Ala, Oakes, Scott A., Papa, Feroz R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Blotting, Western Carrier Proteins - metabolism Cell Line DNA Primers - genetics Endoplasmic Reticulum Stress - physiology Endoribonucleases - metabolism Flow Cytometry Humans Inflammasomes - metabolism Interleukin-1beta - metabolism Mice Mice, Inbred C57BL NLR Family, Pyrin Domain-Containing 3 Protein Protein-Serine-Threonine Kinases - metabolism Real-Time Polymerase Chain Reaction Thioredoxins - metabolism Unfolded Protein Response - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!