Acidic pH conditions mimicking degenerative intervertebral discs impair the survival and biological behavior of human adipose-derived mesenchymal stem cells

This study was designed to examine the survival and biological behavior of adipose-derived mesenchymal stem cells (ADMSCs) under an intervertebral disc (IVD)-like acidic environment. Human ADMSCs isolated from two age groups were cultured under four different pH levels (pH 7.4, 7.1, 6.8 and 6.5) whi...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2012-07, Vol.237 (7), p.845-852
Hauptverfasser:	Li, Hao, Liang, Chengzhen, Tao, Yiqing, Zhou, Xiaopeng, Li, Fangcai, Chen, Gang, Chen, Qi-xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids - metabolism Adipose Tissue - cytology Adipose Tissue - enzymology Adipose Tissue - metabolism Base Sequence Cell Survival DNA Primers Enzyme-Linked Immunosorbent Assay Extracellular Matrix Proteins - metabolism Humans Hydrogen-Ion Concentration Intervertebral Disc Degeneration - metabolism Intervertebral Disc Degeneration - pathology Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - enzymology Mesenchymal Stromal Cells - metabolism Real-Time Polymerase Chain Reaction
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