Increased risk of stroke in oral contraceptive users carried replicated genetic variants: a population-based case–control study in China
Combined oral contraceptives (COC) use is a unique risk factor for stroke in women, and may modify the associations between genetic polymorphisms and stroke. To investigate whether the genetic variants identified in a recent genome-wide association study (GWAS) could be replicated in Chinese women,...
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| Veröffentlicht in: | Human genetics 2012-08, Vol.131 (8), p.1337-1344 |
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| creator | Wang, Chun Li, Ying Li, Huiqiao Sun, Tao Jin, Guangfu Sun, Zhiming Zhou, Jian Ba, Lei Huang, Zhizheng Bai, Jianling |
| description | Combined oral contraceptives (COC) use is a unique risk factor for stroke in women, and may modify the associations between genetic polymorphisms and stroke. To investigate whether the genetic variants identified in a recent genome-wide association study (GWAS) could be replicated in Chinese women, as well as, whether related risk was different in COC users, 451 stroke cases and 831 age- and region-matched controls were recruited from our cohort. Genotyping of 3 SNPs (rs700651, rs10958409, and rs1333040) was performed by the polymerase chain reaction assay with TaqMan probes. The history of contraceptive use and relevant information were obtained from a face-to-face interview. Odds ratios (OR) with 95 % confidence interval (CI) were estimated under conditional logistic regression model after adjustment for cardiovascular covariates. Our study replicated the associations of rs10958409 and rs1333040, with the risk of stroke, especially hemorrhagic subtype, but failed to confirm association of rs700651. COC use was associated with a 1.56-fold (OR 1.56, 95 % CI 1.21–2.01) increased risk of stroke. COC users with rs10958409 GA/AA or rs1333040 CT/TT genotypes had an increased risk of overall stroke by 1.59-fold (OR 2.59, 95 % CI 1.59–4.19) and 3.24-fold (OR 4.24, 95 % CI 1.71–10.49), respectively, compared with the non-users with wild-type genotypes. Moreover, the risk of hemorrhagic stroke increased by 4.81- and 15.06-fold when risk allele carriers of rs10958409 or rs1333040 who took COC. Our results confirmed the associations of two GWAS SNPs, also suggested combination effects of these genetic variants and COC use on stroke risk. |
| doi_str_mv | 10.1007/s00439-012-1161-7 |
| format | Article |
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To investigate whether the genetic variants identified in a recent genome-wide association study (GWAS) could be replicated in Chinese women, as well as, whether related risk was different in COC users, 451 stroke cases and 831 age- and region-matched controls were recruited from our cohort. Genotyping of 3 SNPs (rs700651, rs10958409, and rs1333040) was performed by the polymerase chain reaction assay with TaqMan probes. The history of contraceptive use and relevant information were obtained from a face-to-face interview. Odds ratios (OR) with 95 % confidence interval (CI) were estimated under conditional logistic regression model after adjustment for cardiovascular covariates. Our study replicated the associations of rs10958409 and rs1333040, with the risk of stroke, especially hemorrhagic subtype, but failed to confirm association of rs700651. COC use was associated with a 1.56-fold (OR 1.56, 95 % CI 1.21–2.01) increased risk of stroke. COC users with rs10958409 GA/AA or rs1333040 CT/TT genotypes had an increased risk of overall stroke by 1.59-fold (OR 2.59, 95 % CI 1.59–4.19) and 3.24-fold (OR 4.24, 95 % CI 1.71–10.49), respectively, compared with the non-users with wild-type genotypes. Moreover, the risk of hemorrhagic stroke increased by 4.81- and 15.06-fold when risk allele carriers of rs10958409 or rs1333040 who took COC. Our results confirmed the associations of two GWAS SNPs, also suggested combination effects of these genetic variants and COC use on stroke risk.</description><identifier>ISSN: 0340-6717</identifier><identifier>EISSN: 1432-1203</identifier><identifier>DOI: 10.1007/s00439-012-1161-7</identifier><identifier>PMID: 22476622</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Birth control ; Case-Control Studies ; China ; Contraceptives ; Contraceptives (oral) ; Contraceptives industry ; Contraceptives, Oral - adverse effects ; DNA probes ; Female ; Gene Function ; Gene polymorphism ; Genetic polymorphisms ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Genomes ; Genomics ; Genotyping ; Hemorrhage ; Human Genetics ; Humans ; Ischemia ; Metabolic Diseases ; Molecular Medicine ; Oral contraceptives ; Original Investigation ; Polymerase chain reaction ; Polymorphism, Single Nucleotide ; Population Surveillance ; Regression analysis ; Risk Factors ; Single-nucleotide polymorphism ; Stroke ; Stroke (Disease) ; Stroke - chemically induced ; Stroke - genetics ; User statistics ; Womens health</subject><ispartof>Human genetics, 2012-08, Vol.131 (8), p.1337-1344</ispartof><rights>Springer-Verlag 2012</rights><rights>COPYRIGHT 2012 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-e8caafebad7207eacb12ea7ab1c8ab25bd01f760da8cc3c8d52b90175372215c3</citedby><cites>FETCH-LOGICAL-c506t-e8caafebad7207eacb12ea7ab1c8ab25bd01f760da8cc3c8d52b90175372215c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00439-012-1161-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00439-012-1161-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22476622$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Chun</creatorcontrib><creatorcontrib>Li, Ying</creatorcontrib><creatorcontrib>Li, Huiqiao</creatorcontrib><creatorcontrib>Sun, Tao</creatorcontrib><creatorcontrib>Jin, Guangfu</creatorcontrib><creatorcontrib>Sun, Zhiming</creatorcontrib><creatorcontrib>Zhou, Jian</creatorcontrib><creatorcontrib>Ba, Lei</creatorcontrib><creatorcontrib>Huang, Zhizheng</creatorcontrib><creatorcontrib>Bai, Jianling</creatorcontrib><title>Increased risk of stroke in oral contraceptive users carried replicated genetic variants: a population-based case–control study in China</title><title>Human genetics</title><addtitle>Hum Genet</addtitle><addtitle>Hum Genet</addtitle><description>Combined oral contraceptives (COC) use is a unique risk factor for stroke in women, and may modify the associations between genetic polymorphisms and stroke. To investigate whether the genetic variants identified in a recent genome-wide association study (GWAS) could be replicated in Chinese women, as well as, whether related risk was different in COC users, 451 stroke cases and 831 age- and region-matched controls were recruited from our cohort. Genotyping of 3 SNPs (rs700651, rs10958409, and rs1333040) was performed by the polymerase chain reaction assay with TaqMan probes. The history of contraceptive use and relevant information were obtained from a face-to-face interview. Odds ratios (OR) with 95 % confidence interval (CI) were estimated under conditional logistic regression model after adjustment for cardiovascular covariates. Our study replicated the associations of rs10958409 and rs1333040, with the risk of stroke, especially hemorrhagic subtype, but failed to confirm association of rs700651. COC use was associated with a 1.56-fold (OR 1.56, 95 % CI 1.21–2.01) increased risk of stroke. COC users with rs10958409 GA/AA or rs1333040 CT/TT genotypes had an increased risk of overall stroke by 1.59-fold (OR 2.59, 95 % CI 1.59–4.19) and 3.24-fold (OR 4.24, 95 % CI 1.71–10.49), respectively, compared with the non-users with wild-type genotypes. Moreover, the risk of hemorrhagic stroke increased by 4.81- and 15.06-fold when risk allele carriers of rs10958409 or rs1333040 who took COC. Our results confirmed the associations of two GWAS SNPs, also suggested combination effects of these genetic variants and COC use on stroke risk.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Birth control</subject><subject>Case-Control Studies</subject><subject>China</subject><subject>Contraceptives</subject><subject>Contraceptives (oral)</subject><subject>Contraceptives industry</subject><subject>Contraceptives, Oral - adverse effects</subject><subject>DNA probes</subject><subject>Female</subject><subject>Gene Function</subject><subject>Gene polymorphism</subject><subject>Genetic polymorphisms</subject><subject>Genetic Predisposition to Disease</subject><subject>Genome-Wide Association Study</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Genotyping</subject><subject>Hemorrhage</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Metabolic Diseases</subject><subject>Molecular Medicine</subject><subject>Oral contraceptives</subject><subject>Original Investigation</subject><subject>Polymerase chain reaction</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population Surveillance</subject><subject>Regression analysis</subject><subject>Risk Factors</subject><subject>Single-nucleotide polymorphism</subject><subject>Stroke</subject><subject>Stroke (Disease)</subject><subject>Stroke - 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To investigate whether the genetic variants identified in a recent genome-wide association study (GWAS) could be replicated in Chinese women, as well as, whether related risk was different in COC users, 451 stroke cases and 831 age- and region-matched controls were recruited from our cohort. Genotyping of 3 SNPs (rs700651, rs10958409, and rs1333040) was performed by the polymerase chain reaction assay with TaqMan probes. The history of contraceptive use and relevant information were obtained from a face-to-face interview. Odds ratios (OR) with 95 % confidence interval (CI) were estimated under conditional logistic regression model after adjustment for cardiovascular covariates. Our study replicated the associations of rs10958409 and rs1333040, with the risk of stroke, especially hemorrhagic subtype, but failed to confirm association of rs700651. COC use was associated with a 1.56-fold (OR 1.56, 95 % CI 1.21–2.01) increased risk of stroke. COC users with rs10958409 GA/AA or rs1333040 CT/TT genotypes had an increased risk of overall stroke by 1.59-fold (OR 2.59, 95 % CI 1.59–4.19) and 3.24-fold (OR 4.24, 95 % CI 1.71–10.49), respectively, compared with the non-users with wild-type genotypes. Moreover, the risk of hemorrhagic stroke increased by 4.81- and 15.06-fold when risk allele carriers of rs10958409 or rs1333040 who took COC. Our results confirmed the associations of two GWAS SNPs, also suggested combination effects of these genetic variants and COC use on stroke risk.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22476622</pmid><doi>10.1007/s00439-012-1161-7</doi><tpages>8</tpages></addata></record> |
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| subjects | Biomedical and Life Sciences Biomedicine Birth control Case-Control Studies China Contraceptives Contraceptives (oral) Contraceptives industry Contraceptives, Oral - adverse effects DNA probes Female Gene Function Gene polymorphism Genetic polymorphisms Genetic Predisposition to Disease Genome-Wide Association Study Genomes Genomics Genotyping Hemorrhage Human Genetics Humans Ischemia Metabolic Diseases Molecular Medicine Oral contraceptives Original Investigation Polymerase chain reaction Polymorphism, Single Nucleotide Population Surveillance Regression analysis Risk Factors Single-nucleotide polymorphism Stroke Stroke (Disease) Stroke - chemically induced Stroke - genetics User statistics Womens health |
| title | Increased risk of stroke in oral contraceptive users carried replicated genetic variants: a population-based case–control study in China |
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