Fiber-substituted Conditionally Replicating Adenovirus for Oncolysis of Human Renal Carcinoma Cells

Adenovirus vectors have lately been highlighted in gene therapies. We investigated the oncolytic effects of a chimeric adenovirus type 5 (Ad5) with replacement of Ad5 fiber knob with adenovirus type 35 (Ad35) fiber knob (Ad5F35) on human renal cell carcinoma (RCC). The conditionally replicating Ad5F...

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Veröffentlicht in:	Anticancer research 2012-07, Vol.32 (7), p.2985-2989
Hauptverfasser:	NAGAYA, Hisao, TAGAWA, Masatoshi, HIWASA, Kazuhiro, TERAO, Shuji, KANNO, Takeshi, NISHIZAKI, Tomoyuki, GOTOH, Akinobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviridae - physiology Adenovirus Adenovirus E1 Proteins - genetics Biological and medical sciences Carcinoma, Renal Cell - therapy Carcinoma, Renal Cell - virology CD46 antigen Cell Line, Tumor Cell surface Coxsackie and Adenovirus Receptor-Like Membrane Protein Cytokines - genetics Expression vectors Fibers Gene therapy Genetic Therapy - methods Genetic Vectors HEK293 Cells Humans Kidney Neoplasms - therapy Kidney Neoplasms - virology Kidneys Medical sciences Membrane Cofactor Protein - biosynthesis Membrane Cofactor Protein - genetics Nephrology. Urinary tract diseases Oncolysis Oncolytic Virotherapy - methods Promoter Regions, Genetic Receptors, Virus - biosynthesis Receptors, Virus - genetics renal cell carcinoma RNA, Messenger - biosynthesis RNA, Messenger - genetics Tumors Tumors of the urinary system Virus Replication Western blotting
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