MGMT hypermethylation and MDR system in glioblastoma cancer stem cells

Cancer stem cells (CSCs) in gliomas are associated with resistance to radio- and chemotherapy, based on O(6)-methylguanine-DNA methyltransferase (MGMT) hypermethylation and the Multidrug resistance (MDR) system activation. Samples from 21 glioblastomas (GBMs) were put in culture with growth factors...

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Veröffentlicht in:	Cancer genomics & proteomics 2012-07, Vol.9 (4), p.171-178
Hauptverfasser:	Caldera, Valentina, Mellai, Marta, Annovazzi, Laura, Monzeglio, Oriana, Piazzi, Angela, Schiffer, Davide
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over ATP Binding Cassette Transporter, Sub-Family B ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Brain Neoplasms - metabolism Cells, Cultured DNA Methylation DNA Modification Methylases - genetics DNA Modification Methylases - metabolism DNA Repair Enzymes - genetics DNA Repair Enzymes - metabolism Drug Resistance, Multiple - genetics Female Gene Expression Regulation, Neoplastic Glioblastoma - metabolism Humans Male Middle Aged Multidrug Resistance-Associated Proteins - genetics Multidrug Resistance-Associated Proteins - metabolism Neoplastic Stem Cells - metabolism Promoter Regions, Genetic Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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