Synergistic antitumor activity of lapatinib and retinoids on a novel subtype of breast cancer with coamplification of ERBB2 and RARA

All -trans retinoic acid (ATRA), the only clinically available cyto-differentiating agent, has potential for the therapy/chemoprevention of breast carcinoma. Given the heterogeneous nature of this tumor, a rational use of ATRA and derivatives (retinoids) in the clinic requires the identification of...

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Veröffentlicht in:	Oncogene 2012-07, Vol.31 (29), p.3431-3443
Hauptverfasser:	Paroni, G, Fratelli, M, Gardini, G, Bassano, C, Flora, M, Zanetti, A, Guarnaccia, V, Ubezio, P, Centritto, F, Terao, M, Garattini, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antitumor activity Apoptosis Breast cancer Breast carcinoma Breast Neoplasms - genetics Breast Neoplasms - metabolism Cell Biology Cell Line, Tumor Chemotherapy Drug Synergism Drug therapy ErbB-2 protein Estrogen receptors Estrogens Forkhead Box Protein O3 Forkhead Transcription Factors - metabolism FOXO3 protein Gene Amplification - drug effects Gene expression Genetic aspects Growth inhibition Health aspects Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Molecular modelling Oncology original-article Phosphorylation Phosphorylation - drug effects Physiological aspects Post-transcription Proteins Quinazolines - pharmacology Receptor, ErbB-2 - antagonists & inhibitors Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Receptors, Retinoic Acid - genetics Receptors, Retinoic Acid - metabolism Retinoic Acid Receptor alpha Retinoic acid receptors Retinoids Smad3 Protein - metabolism Toxicity Transcription activation Transcription factors Transcription, Genetic - drug effects Transcriptome - drug effects Transforming Growth Factor beta - metabolism Transforming growth factor- beta Tretinoin - pharmacology Tumor cells Tumors
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