Pharmacokinetics, tissue distribution and immunomodulatory effect of intralipid formulation of nystatin in mice

We developed a novel lipid formulation of nystatin suitable for parenteral administration, nystatin-intralipid (NYT-IL), with antifungal activity and reduced toxicity in mice. We investigated the pharmacokinetics, tissue distribution and immunomodulatory effect of NYT-IL in mice. Nystatin levels in...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2012-07, Vol.67 (7), p.1716-1721
Hauptverfasser:	SEMIS, Rita, NILI, Shai Shmuel, MUNITZ, Ariel, ZASLAVSKY, Zeev, POLACHECK, Itzhack, SEGAL, Esther
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Structures - chemistry Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal activity Antifungal Agents - administration & dosage Antifungal Agents - pharmacokinetics Antimicrobial agents Biological and medical sciences Cytokines Cytokines - secretion Emulsions - administration & dosage Emulsions - adverse effects Emulsions - pharmacokinetics Enzyme-linked immunosorbent assay Female gamma -Interferon High-performance liquid chromatography Immune response Immunologic Factors - administration & dosage Immunologic Factors - adverse effects Immunologic Factors - pharmacokinetics Immunomodulation Inflammation Interleukin 10 Kidney Kinetics Leukocytes, Mononuclear - immunology Lipids Liver Medical sciences Mice Mice, Inbred ICR Nystatin Nystatin - administration & dosage Nystatin - adverse effects Nystatin - pharmacokinetics Pharmacokinetics Pharmacology Pharmacology. Drug treatments Phospholipids - administration & dosage Phospholipids - adverse effects Phospholipids - pharmacokinetics polyenes Rodents Serum - chemistry Side effects Soybean Oil - administration & dosage Soybean Oil - adverse effects Soybean Oil - pharmacokinetics Spleen - immunology Splenocytes Tissue Distribution TNF inhibitors Toxicity Tumor necrosis factor- alpha
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