Cationic cyclodextrins: cell penetrating agents and other diverse applications
The positively charged cyclodextrins (CDs) have attracted wide attention in the last years, as also have other positively charged molecules e.g. dendrimers polymers, and various oligomers. The interest arises mainly form the coexistence of a CD cavity for molecular entrapment and a positively charge...
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| Veröffentlicht in: | Journal of drug delivery science and technology 2012, Vol.22 (3), p.243-249 |
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| container_title | Journal of drug delivery science and technology |
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| creator | Yannakopoulou, K. |
| description | The positively charged cyclodextrins (CDs) have attracted wide attention in the last years, as also have other positively charged molecules e.g. dendrimers polymers, and various oligomers. The interest arises mainly form the coexistence of a CD cavity for molecular entrapment and a positively charged corona that can additionally stabilize the inclusion via electrostatic forces. More over, positively charged CDs may act as catalysts of various organic reactions, form supramolecular capsules in solution with negatively charged CDs, encapsulate anionic guest such as nucleotides, act as inhibitors of virulence factors by blocking the pores of pore-forming proteins, and finally act as cell penetrating (CPCDs) and DNA delivery agents. Therefore cationic CDs constitute a remarkable family of drug delivery molecules with high potential and diverse applications. |
| doi_str_mv | 10.1016/S1773-2247(12)50035-3 |
| format | Article |
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The interest arises mainly form the coexistence of a CD cavity for molecular entrapment and a positively charged corona that can additionally stabilize the inclusion via electrostatic forces. More over, positively charged CDs may act as catalysts of various organic reactions, form supramolecular capsules in solution with negatively charged CDs, encapsulate anionic guest such as nucleotides, act as inhibitors of virulence factors by blocking the pores of pore-forming proteins, and finally act as cell penetrating (CPCDs) and DNA delivery agents. 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Therefore cationic CDs constitute a remarkable family of drug delivery molecules with high potential and diverse applications.</description><subject>Biological and medical sciences</subject><subject>Catalysts</subject><subject>Cavities</subject><subject>Cell penetration</subject><subject>cyclodextrin</subject><subject>DNA</subject><subject>DNA transfection</subject><subject>Drug delivery</subject><subject>Electrostatic properties</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Nucleotides</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. 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| ispartof | Journal of drug delivery science and technology, 2012, Vol.22 (3), p.243-249 |
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| language | eng |
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| subjects | Biological and medical sciences Catalysts Cavities Cell penetration cyclodextrin DNA DNA transfection Drug delivery Electrostatic properties General pharmacology Medical sciences Nucleotides Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments pore-forming proteins Pores Protein pore blocking virulence factors |
| title | Cationic cyclodextrins: cell penetrating agents and other diverse applications |
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