ABCB1 C3435T Genetic Polymorphism on Population Pharmacokinetics of Methotrexate After Hematopoietic Stem Cell Transplantation in Korean Patients: A Prospective Analysis

Abstract Background Methotrexate (MTX) is often used to prevent graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). However, MTX has great pharmacokinetic variability and its use can result in fatal complications and/or infections after HSCT. Objectives...

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Veröffentlicht in:	Clinical therapeutics 2012-08, Vol.34 (8), p.1816-1826
Hauptverfasser:	Kim, In-Wha, PhD, Yun, Hwi-yeol, PhD, Choi, Boyoon, MS, Han, Nayoung, MS, Park, Seon-Yang, MD, PhD, Lee, Eun Sook, PharmD, Oh, Jung Mi, PharmD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Anti-Bacterial Agents - therapeutic use ATP Binding Cassette Transporter, Sub-Family B ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Biological and medical sciences Blood diseases Bone marrow Chi-Square Distribution Drug Interactions Female Genotype Glomerular Filtration Rate Graft vs Host Disease - etiology Graft vs Host Disease - prevention & control hematopoietic stem cell transplantation Hematopoietic Stem Cell Transplantation - adverse effects Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - blood Immunosuppressive Agents - pharmacokinetics Internal Medicine Leukemia Male Medical Education Medical sciences Metabolic Clearance Rate methotrexate Methotrexate - administration & dosage Methotrexate - blood Methotrexate - pharmacokinetics Middle Aged Models, Biological nonlinear mixed-effect modeling (NONMEM) Penicillins - therapeutic use pharmacogenetics Pharmacology. Drug treatments Phenotype Polymorphism, Genetic population pharmacokinetics Prospective Studies Republic of Korea Stem cells Studies Transplants & implants Treatment Outcome Young Adult
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