Analgesic Efficacy and Tolerability of Intravenous Morphine Versus Combined Intravenous Morphine and Oxycodone in a 2-Center, Randomized, Double-Blind, Pilot Trial of Patients With Moderate to Severe Pain After Total Hip Replacement

Abstract Background Results from studies with a combination of oral morphine and oxycodone in postsurgical patients demonstrate significant analgesia and a tolerability profile comparable to other pain medications at morphine-equivalent doses. However, an intravenous (IV) combination has not previou...

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Veröffentlicht in:	Clinical therapeutics 2012-08, Vol.34 (8), p.1751-1760
Hauptverfasser:	Joppich, Robin, MD, Richards, Patricia, MD, PhD, Kelen, Robin, MS, RN, Stern, Warren, PhD, Zarghooni, Kourosh, MD, Otto, Christina, MD, Böhmer, Andreas, MD, Petzke, Frank, MD, Treptau, Tilman, PhD, Lefering, Rolf, PhD, Bäthis, Holger, MD, Neugebauer, Edmund, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over analgesia Analgesia, Patient-Controlled - adverse effects Analgesics Analgesics, Opioid - administration & dosage Analgesics, Opioid - adverse effects Arthroplasty, Replacement, Hip - adverse effects Biological and medical sciences Blood pressure Bone surgery Chi-Square Distribution Double-Blind Method Drug Administration Schedule Drug Combinations Female Germany Humans Injections, Intravenous Internal Medicine intravenous Joint replacement surgery Male Medical Education Medical sciences Middle Aged morphine Morphine - administration & dosage Morphine - adverse effects oxycodone Oxycodone - administration & dosage Oxycodone - adverse effects Pain management Pain Measurement Pain, Postoperative - diagnosis Pain, Postoperative - etiology Pain, Postoperative - prevention & control Pharmacology. Drug treatments Pilot Projects postoperative pain Studies Time Factors tolerability Treatment Outcome
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